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Original Article

Telomere Shortening Correlates with Prognostic Score at Diagnosis and Proceeds Rapidly during Progression of Chronic Myeloid Leukemia

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Pages 1775-1781 | Received 10 Dec 2003, Published online: 03 Aug 2009

References

  • Harley, C.B., Futcher, A.B. and Greider, C.W. (1990) "Telomeres shorten during ageing of human fibroblasts", Nature, 345, 458 —460.
  • Vaziri, H., Schachter, F., Uchida, I., Wei, L., Zhu, X., Effros, R., et al. (1993) "Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes", American Journal of Human Genetics, 52, 661 —667.
  • Counter, C.M., Avilion, A.A., LeFeuvre, C.E., Stewart, N.G., Greider, C.W., Harley, C.B., et al. (1992) "Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity", European Molecular Biology Organization Journal, 11, 1921–1929.
  • Jonas, D., Lubbert, M., Kawasaki, E.S., Henke, M., Bross, K.J., Mertelsmann, R., et al. (1992) "Clonal analysis of bcr-abl rearrangement in T lymphocytes from patients with chronic myelogenous leukemia", Blood, 79, 1017–1023.
  • Haferlach, T., Winkemann, M., Nickenig, C., Meeder, M., Ramm-Petersen, L., Schoch, R., et al. (1997) "Which compartments are involved in Philadelphia-chromosome positive chronic myeloid leukaemia? An answer at the single cell level by combining May-Grunwald-Giemsa staining and fluorescence in situ hybridization techniques", British Journal of Haematology, 97, 99— 106.
  • Brummendorf, T.H., Holyoake, T.L., Rufer, N., Barnett, M.J., Schulzer, M., Eaves, C.J., et al. (2000) "Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry", Blood, 95, 1883— 1890.
  • Cervantes, F., Robertson, J.E., Rozman, C., Baccarani, M., Tura, S., Gomez, G.A., et al. (1994) "Long-term survivors in chronic granulocytic leukaemia: a study by the International CGL Prog-nosis Study Group. Italian Cooperative CML Study Group", British Journal of Haematology, 87, 293–300.
  • Sokal, J., Cox, E., Baccarani, M., Tura, S., Gomez, G., Robertson, J., et al. (1984) "Prognostic discrimination in 'good-risk' chronic granulocytic leukemia", Blood, 63, 789–799.
  • Hasford, J., Pfirrmann, M., Hehlmann, R., Allan, N., Baccarani, M., Kluin-Nelemans, J., et al. (1998) "A new prognostic score for survival of patients with chronic myeloid leukaemia treated with interferon alpha", Journal of the National Cancer Institute, 90, 850 — 858.
  • Boultwood, J., Fidler, C., Shepherd, P., Watkins, F., Snowball, J., Haynes, S., et al. (1999) "Telomere length shortening is associated with disease evolution in chronic myeloid leukaemia", American Journal of Hematology, 61, 5–9.
  • Boultwood, J., Peniket, A., Watkins, F., Shepherd, P., McGale, P., Richards, S., et al. (2000) "Telomere length shortening in chronic myelogenous leukaemia is associated with reduced time to accelerated phase", Blood, 96, 358–361.
  • Vardiman, J.W., Pierre, R., Thiele, J., Imbert, M., Brunning, R.D. and Flandrin, G. (2001) Tumours of haematopoietic and lymphoid tissues. In WHO Classification of Tumours. Pathology and Genetics, edited by E.S. Jaffe, N.L. Harris, H. Stein and J.W. Vardiman. Pp 20–26 (1st edn). Lyon: IARC Press.
  • Rufer, N., Dragowska, W., Thornbury, G., Roosnek, E. and Lansdorp, P.M. (1998) "Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry", Nature Biotechnology, 16, 743–747.
  • Rufer, N., Brummendorf, T.H., Kolvraa, S., Bischoff, C., Chris-tensen, K., Wadsworth, L., et al. (1999) "Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood", Journal of Experimental Medicine, 190, 157–167.
  • Slagboom, P.E., Droog, S. and Boomsma, D.I. (1994) "Genetic determination of telomere size in humans: A twin study of three age groups", American Journal of Human Genetics, 55, 876–882.
  • Drukerm, B.J., Talpaz, M., Resta, D.J., Peng, B., Buchdunger, E., Ford, J.M., et al. (2001) "Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia", New England Journal of Medicine, 344, 1031–1037.
  • Druker, B.J., Sawyers, C.L., Kantarjian, H., Resta, D.J., Reese, S.F., Ford, J.M., et al. (2001) "Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome", New England Journal of Medicine, 344, 1038 — 1042.
  • Brummendorf, T.H., Ersoz, I., Hartmann, U., Bartolovic, K., Balabanov, S., Wahl, A., et al. (2003) "Telomere length in peripheral blood granulocytes reflects response to treatment with imatinib in patients with chronic myeloid leukemia", Blood, 101, 375–376.
  • Baerlocher, G.M., Mak, J., Tien, T. and Lansdorp, P.M. (2002) "Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls", Cytometry, 47, 89–99.
  • Brummendorf, T.H., Rufer, N., Holyoake, T.L., Maciejewski, J., Barnett, M.J., Eaves, C.J., et al. (2001) "Telomere length dynamics in normal individuals and in patients with hematopoietic stem cell-associated disorders", Annals of the New York Academy of Sciences, 938, 293 — 303; discussion 303 — 294.
  • Holyoake, T.L., Jiang, X., Drummond, M.W., Eaves, A.C. and Eaves, C.J. (2002) "Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia", Leukemia, 16, 549— 558.
  • Oikawa, S. and Kawanishi, S. (1999) "Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere short-ening", FEBS Letters, 453, 365–368.
  • von Zglinicki, T., Pilger, R. and Sitte, N. (2000) "Accumulation of single-stranded breaks is the major cause of telomere shortening in human fibroblasts", Free Radical Biology and Medicine, 28, 64–74.
  • Sattler, M., Verma, S., Shrikhande, G., Byrne, C.H., Pride, Y.B., Winkler, T., et al. (2000) "The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells", Journal of Biological Chemistry, 275, 24273–24278.
  • Deutsch, E., Dugray, A., AbdulKarim, B., Marangoni, E., Maggiorella, L., Vaganay, S., et al. (2001) "BCR-ABL down-regulates the DNA repair protein DNA-PKcs", Blood, 97, 2084 — 2090.
  • Ichimaru, M., Ishimaru, T., Mikami, M., Yamada, Y. and Ohkita, T. (1981) Incidence of leukemia in a fixed cohort of atomic bomb survivors and controls, Hiroshima and Nagasaki October 1950—December 1978: Technical Report RERF TR 13-81. Hiroshima: Radiation Effects Research Foundation.

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