Multiplex Real-time RT–PCR for Prospective Evaluation of WT1 and Fusion Gene Transcripts in Newly Diagnosed De Novo Acute Myeloid Leukemia

References

• Grimwade, D., Walker, H., Oliver, F., Wheatley, K., Harrison, C., Harrison, G., et al. (1998) "The importance of diagnostic cytogenetics on outcome in Aml: Analysis of 1,612 patients entered into the Mrc Aml 10 Trial. The Medical Research Council Adult and Children's Leukaemia Working Parties", Blood, 92, 2322–2333.
   Google Scholar
• Bloomfield, C.D., Lawrence, D., Byrd, J.C., Carroll, A., Pettenati, M.J., Tantravahi, R., et al. (1998) "Frequency of prolonged remission duration after high-dose cytarabine intensification in Acute Myeloid Leukemia varies by cytogenetic subtype", Cancer Res., 58, 4173–4179.
   Google Scholar
• Slovak, M.L., Kopecky, K.J., Cassileth, P.A., Harrington, D.H., Theil, KS., Mohamed, A., et al. (2000) "Karyotypic analysis predicts outcome of preremission and postremission therapy in adult Acute Myeloid Leukemia: A Southwest Oncology Group/ Eastern Cooperative Oncology Group Study", Blood, 96, 4075–4083.
   Google Scholar
• Grimwade, D., Walker, H., Harrison, G., Oliver, F., Chatters, S., Harrison, C.J., et al. (2001) "The predictive value of hierarchical cytogenetic classification in older adults with Acute Myeloid Leukemia (Amp: Analysis of 1065 patients entered into the United Kingdom Medical Research Council Am111 Trial", Blood, 98, 1312–1320.
   Google Scholar
• Call, KM., Glaser, T., Ito, C.Y., Buckler, A.J., Pelletier, J., Haber, D.A., et al. (1990) "Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus", Cell, 60, 509 — 520.
   Google Scholar
• Baird, P.N. and Simmons, P.J. (1997) "Expression of the Wilms' TUMOR GEne (Wtl) in normal hemopoiesis", Exp. Hematol., 25, 312 — 320.
   Google Scholar
• Menssen, H.D., Renkl, Hi., Entezami, M. and Thiel, E. (1997) "Wilms' tumor gene expression in human Cd34 + hematopoietic progenitors during fetal development and early clonogenic growth", Blood, 89, 3486 — 3487.
   Google Scholar
• Ellisen, LW., Carlesso, N., Cheng, T., Scadden, D.T. and Haber, D.A. (2001) "The Wilms tumor suppressor WO directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells", Embo J., 20, 1897–1909.
   Google Scholar
• Miyagi, T., Ahuja, H., Kubota, T., Kubonishi, I., Koeffier, H.P. and Miyoshi, I. (1993) "Expression of the candidate Wilms' tumor gene, Wtl, in human leukemia cells", Leukemia, 7, 970–977.
   Google Scholar
• Miwa, H., Beran, M. and Saunders, G.F. (1992) "Expression of the Wilms' tumor gene (Wtl) in human leukemias", Leukemia, 6, 405 — 409.
   Google Scholar
• Menssen, H.D., Renkl, Hi., Rodeck, U., Maurer, J., Notter, M., Schwartz, S., et al. (1995) "Presence of Wilms' tumor gene (Wtl) transcripts and the Wtl nuclear protein in the majority of human acute leukemias", Leukemia, 9, 1060–1067.
   Google Scholar
• Inoue, K., Ogawa, H., Sonoda, Y., Kimura, T., Sakabe, H., Oka, Y., et al. (1997) "Aberrant overexpression of the Wilms' tumor gene (Wtl) in human leukemia", Blood, 89, 1405–1412.
   Google Scholar
• Bergmann, L., Miething, C., Maurer, U., Brieger, J., Karakas, T., Weidmann, E., et al. (1997) "High levels of Wilms' tumor gene (Wtl) Mrna in acute myeloid leukemias are associated with a worse long-term outcome", Blood, 90, 1217–1225.
   Google Scholar
• Inoue, K., Sugiyama, H., Ogawa, H., Nakagawa, M., Yamagami, T., Miwa, H., et al. (1994) "WO as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia", Blood, 84, 3071— 3079.
   Google Scholar
• Trka, J., Kalinova, M., Hrusak, 0., Zuna, J., Krejci, 0., Madzo, J., et al. (2002) "Real-time quantitative Per detection of WO gene expression in children with Aml: Prognostic significance, correlation with disease status and residual disease detection by flow cytometry", Leukemia, 16, 1381–1389.
   Google Scholar
• Garg, M., Moore, H., Tobal, K. and Liu Yin, J.A. (2003) "Prognostic significance of quantitative analysis of WO gene transcripts by competitive reverse transcription polymerase chain reaction in acute leukaemia", Br. J. HaematoL, 123, 49— 59.
   Google Scholar
• Schmid, D., Heinze, G., Linnerth, B., Tisljar, K., Kusec, R., Geissler, K., et al. (1997) "Prognostic significance of Wtl gene expression at diagnosis in adult de novo acute myeloid Leukemia", Leukemia, 11, 639–643.
   Google Scholar
• Inoue, K., Ogawa, H., Yamagami, T., Soma, T., Tani, Y., Tatekawa, T., et al. (1996) "Long-term follow-up of minimal residual disease in leukemia patients by monitoring WO (Wilms tumor gene) expression levels", Blood, 88, 2267–2278.
   Google Scholar
• Gaiger, A., Schmid, D., Heinze, G., Linnerth, B., Greinix, H., Kalhs, P., et al. (1998) "Detection of the Wtl transcript by Rt-Pcr in complete remission has no prognostic relevance in de novo acute myeloid leukemia", Leukemia, 12, 1886–1894.
   Google Scholar
• Elmaagacli, A.H., Beelen, D.W., Trenschel, R. and Schaefer, U.W. (2000) "The detection of Wt-1 transcripts is not associated with an increased leukemic relapse rate in patients with acute leukemia after allogeneic bone marrow or peripheral blood stem cell transplanta-tion", Bone Marrow Transplant, 25, 91–96.
   Google Scholar
• Cilloni, D., Gottardi, E., De Micheli, D., Serra, A., Volpe, G., Messa, F., et al. (2002) "Quantitative assessment of Wtl expression by Real Time Quantitative Per may be a useful tool for monitoring minimal residual disease in acute leukemia Patients", Leukemia, 16, 2115–2121.
   Google Scholar
• Ogawa, H., Tamaki, H., Ikegame, K., Soma, T., Kawakami, M., Tsuboi, A., et al. (2003) "The usefulness of monitoring WO gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia", Blood, 101, 1698–1704.
   Google Scholar
• Osumi, K., Fukui, T., Kiyoi, H., Kasai, M., Kodera, Y., Kudo, K., et al. (2002) "Rapid screening of leukemia fusion transcripts in acute leukemia by Real-Time Per", Leuk. Lymphoma, 43, 2291— 2299.
   Google Scholar
• Bennett, J.M., Catovsky, D., Daniel, MT., Flandrin, G., Galton, D.A., Gralnick, H.R., et al. (1985) "Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group", Ann. Intern. Med., 103, 620— 625.
   Google Scholar
• Scherf, U., Ross, D.T., Waltham, M., Smith, L.H., Lee, J.K., Tanabe, L., et al. (2000) "A gene expression database for the molecular pharmacology of cancer", Nat. Genet., 24, 236–244.
   Google Scholar
• Alizadeh, A.A., Eisen, MB., Davis, RE., Ma, C., Lossos, IS., Rosenwald, A., et al. (2000) "Distinct types of diffuse large B-Cell Lymphoma identified by Gene Expression Profiling", Nature, 403, 503— 511.
   Google Scholar
• Okutsu, J., Tsunoda, T., Kaneta, Y., Katagiri, T., Kitahara, 0., Zembutsu, H., et al. (2002) "Prediction of chemosensitivity for patients with acute myeloid leukemia, according to expression levels of 28 genes selected by genome-wide complementary DNA microarray analysis", Mol. Cancer Ther., 1, 1035–1042.
   Google Scholar
• Kiyoi, H., Naoe, T., Nakano, Y., Yokota, S., Minami, S., Miyawalci, S., et al. (1999) "Prognostic implication of F1t3 and N-Ras gene mutations in acute myeloid leukemia", Blood, 93, 3074 — 3080.
   Google Scholar
• Kottaridis, P.D., Gale, RE., Frew, ME., Harrison, G., Langabeer, SE., Belton, A.A., et al. (2001) "The presence of a F1t3 internal tandem duplication in patients with acute myeloid leukemia (Aml) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council Aml 10 and 12 trials", Blood, 98, 1752–1759.
   Google Scholar
• Schnittger, S., Schoch, C., Dugas, M., Kern, W., Staib, P., Wuchter, C., et al. (2002) "Analysis of F1t3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, Fab subtype, and prognosis in the Amlcg study and usefulness as a marker for the detection of minimal residual disease", Blood, 100, 59–66.
   Google Scholar
• Frohling, S., Schlenk, R.F., Breitruck, J., Benner, A., Kreitmeier, S., Tobis, K., et al. (2002) "Prognostic significance of activating F1t3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the Aml study group Ulm", Blood, 100, 4372–4380.
   Google Scholar