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Original Article

Expression of ZAP-70 Protein Correlates with Disease Stage in Chronic Lymphocytic Leukemia and is Associated with, but not Generally Restricted to, Non-mutated Ig VH Status

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Pages 2037-2045 | Received 04 Apr 2004, Published online: 03 Aug 2009

References

  • Hamblin, T.J., Davis, Z., Gardiner, A., Oscier, D.G. and Stevenson, F.K. (1999) "Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia", Blood, 94, 1848–1854.
  • Damle, R.N., Wasil, T., Fais, F., Ghiotto, F., Valetto, A., Allen, S.L., et al. (1999) "Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia", Blood, 94, 1840— 1847.
  • Hamblin, T.J., Orchard, J.A., Gardiner, A., Oscier, D.G., Davis, Z. and Stevenson, F.K. (2000) "Immunoglobulin V genes and CD38 expression in CLL", Blood, 95, 2455 —2457.
  • Naylor, M. and Capra, J.D. (1999) "Mutational status of Ig V(H) genes provides clinically valuable information in B-cell chronic lymphocytic leukemia", Blood, 94, 1837— 1839.
  • Takata, M., Sabe, H., Hata, A., Inazu, T., Homma, Y., Nukada, T., etal. (1994) "Tyrosine lcinases Lyn and Syk regulate B cell receptor-coupled Ca2 + mobilization through distinct pathways", EMBO J, 13, 1341–1349.
  • Kurosalci, T., Takata, M., Yamanashi, Y., Inazu, T., Taniguchi, T., Yamamoto, T., et al. (1994) "Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling", J Exp Med, 179, 1725–1729.
  • Nagai, K., Takata, M., Yamamura, H. and Kurosaki, T. (1995) "Tyrosine phosphorylation of She is mediated through Lyn and Syk in B cell receptor signaling", J Biol Chem, 270, 6824–6829.
  • Arpaia, E., Shahar, M., Dadi, H., Cohen, A. and Roifman, C.M. (1994) "Defective T cell receptor signaling and CD8 + thymic selection in humans lacking ZAP-70 lcinase", Cell, 76, 947 —958.
  • Schweighoffer, E., Vanes, L., Mathio, A., Nakamura, T. and Tybulewicz, V.L.J. (2003) "Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion", Immunity, 18, 523–533.
  • Rosenwald, A., Alizadeh, A.A., Widhopf, G., Simon, R., Davis, RE., Yu, X., et al. (2001) "Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia", J Exp Med, 194, 1639 — 1647.
  • Cheson, B.D., Bennett, J.M., Greyer, M., Kay, N., Keating, Mi., O'Brien, S., et al. (1996) "National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment", Blood, 87, 4990–4907.
  • Matutes, E., Oscier, D., Garcia-Marco, J., Ellis, J., Copplestone, A., Gillingham, R., et al. (1996) "Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients", Br J Haematol, 92, 382–328.
  • Harris, N.L., Jaffe, ES., Diebold, J., Flandrin, G., Muller-Hermelink, H.K., Vardiman, J., et al. (1999) "The World Health Organization Classification of Neoplastic Disease of the Hemato-poetic and Lymphoid Tissues", Ann Oncol, 10, 1419 — 1432.
  • Kanzler, H., Kuppers, R., Hansmann, M.L. and Rajewsky, K. (1996) "Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells", J Exp Med, 184, 1495–1505.
  • Brauninger, A., Kuppers, R., Spieker, T., Siebert, R., Strickler, J.G., Schlegelberger, B., et al. (1999) "Molecular analysis of single B cells from T-cell-rich B-cell lymphomas shows the derivation of the tumor cells-from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells", Blood, 93, 2679 — 2687.
  • Brauninger, A., Kuppers, R., Stricker, J.G., Wacker, H.H., Rajewsky, K. and Hansmann, M.L. (1997) "Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells", Proc Natl Acad Sci USA, 94, 9337–9342.
  • Schlegelberger, B., Metzke, S., Harder, S., Ziihlke-Jenisch, R., Zhang, Y. and Siebert, R. (1999) Classical and molecular cytogenetics of tumor cells. In Cytogenetics, edited by R. Wegener. P 151. New York, NY: Springer-Verlag.
  • Chen, L., Widhof, G., Huynh, L., Rassenti, L., Rai, KR., Weiss, R. et al. (2002) "Expression of ZAP-70 is associated with increased B cell receptor signaling in chronic lymphocytic leukemia", Blood, 100, 4609 — 4614.
  • Wiestner, A., Rosenwald, A., Barry, T.S., Wright, G., Davis, R.C., Henrickson, SE., et al. (2003) "ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglo-bulin genes, inferior outcome, and distinct gene expression profile", Blood, 101, 4944–4951.
  • Crespo, M., Bosch, F., Villamor, N., Bellosillo, B., Colomer, D., Rozman, M., et al. (2003) "ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia", N Eng! J Med, 348, 1764 — 1775.
  • Orchard, JA., Ibbotson, RE., Davis, Z., Wiestner, A., Rosenwald, A., Thomas, P.W., et al. (2004) "ZAP-70 expression and prognosis in chronic lymphocytic leukaemia", Lancet, 363, 105 — 111.
  • Tobin, G., Thunberg, U., Thorn, I., Soderberg, 0., Hultdin, M., Botling, J., et al. (2002) "Somatically mustated Ig VH3-21 genes characterize a new subset of chronic lymphocytic leukemia", Blood, 99, 2262–2264.
  • Hamblin, Ti., Orchard, JA., Ibbotson, RE., Davis, Z., Thomas, P.W., Stevenson, F.K., et al. (2002) "CD38 expression and immunoglobulin variable region mutations are independent prog-nostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease", Blood, 99, 1023–1029.
  • Döhner, H., Stilgenbauer, S., Benner, A., Leupolt, E., Kröber, A., Bullinger, L., et al. (2000) "Genomic aberrations and survival in chronic lymphocytic leukemia", N Eng! J Med, 343, 1910— 1916.
  • Chan, AC., van Oers, N.S., Tran, A., Turka, L., Law, CL., Ryan, J.C., et al. (1994) "Differential expression of ZAP-70 and Syk protein tyrosine lcinases, and the role of this family of protein tyrosine kinases in TCR signaling", J Immunol, 152, 4758–4766.
  • Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R.P. and Samelson, L.E. (1998) "LAT: the ZAP-70 tyrosine lcinase substrate that links T cell receptor to cellular activation", Cell, 92, 83–92.
  • Wu, J., Motto, D.G., Koretzky, G.A. and Weiss, A. (1996) "Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation", Immunity, 4, 593–602.
  • Raab, M., da Silva, A.J., Findell, P.R. and Rudd, C.E. (1997) "Regulation of Vav-SLP-76 binding by Ap-70 and its relevance to TCT-zeta/CD3 induction of interleulcin-2", Immunity, 6, 155–164.
  • Qian, D., Prenner-Griswold, I., Rosner, M.R. and Fitch, F.W. (1993) "Multiple components of the T cell antigen receptor complex become tyrosine phosphorylated upon activation", J Biol Chem, 268, 4488–4493.

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