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Original Article

Blastic Natural Killer (NK)-Cell Lymphoma: Report of an Unusual CD4 Negative Case and Review of the CD4 Negative Neoplasms with Blastic Features in the Literature

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Pages 2127-2133 | Received 30 May 2004, Published online: 03 Aug 2009

References

  • Spits, H., Lanier, L.L. and Phillips, J. H. (1995) "Development of human T and natural killer cells", Blood, 85, 2654 — 2670.
  • Le, Ph.T., Adams, K.L., Zaya, N., Mathews, H.L., Storkus W.J. and Ellis, Th.M. (2001) "Human thymic epithelial cells inhibit IL-15- and IL-2-driven differentiation of NK cells from the early human thymic progenitors", Journal of Immunology, 166, 2194 — 2201.
  • Greer, J.P., Kinney M.C. and Loughran, T.P. Jr. (2001) "T cell and NK cell lymphoproliferative disorders", Haematology (Am. Soc. Hematol. Educ. Program), 101, 259–281.
  • Phillips, J.H., Hori, T., Nagler, A., Bhat, N., Spits, H. and Lanier, L.L. (1992) "Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins", Journal of Experimental Medicine, 175, 1055 —1066.
  • Kinney, M.C. (1999) "The role of morphologic features, phenotype, genotype and anatomic site in defining extranodal T and NK cell neoplasms". American Journal of Clinical Pathology, 111, S104 — S118.
  • Mori, N., Yamashita, Y., Tsuzulci, T., Nakayama, A., Hasegawa, Y., Kojima, H., et al. (2000) "Lymphomatous features of aggressive NK leukemia/lymphoma with massive necrosis, haemophagocytosis and EB virus infection", Histopathology, 37, 363–371.
  • Quintanilla-Martinez, L. and Jaffe, E.S. (2000) "Aggressive NK cell lymphomas: insights into the spectrum of NK cell derived malignancies", Histopathology, 37, 372— 374.
  • Lamy, Th. and Loughran, T.P. Jr. (1998) "Large granular lymphocyte leukemia", Cancer Control, 5, 25— 33.
  • Drexler, H.G. and Matsuo, Y. (2000) "Malignant haematopoietic cell lines: in vitro models for the study of natural killer cell-leukemia-lymphoma", Leukemia, 14, 777–782.
  • Jaffe, ES., Krenacs, L., Kumar, S., Kingma, D.W. and Raffeld, M. (1999) "Extranodal Peripheral T-cell and NK-cell neoplasms", American Journal of Clinical Pathology, 111, S46—S55.
  • Suzuki, R. and Nakamura, S. (1998) "Malignancies of natural killer (NK) cell precursor: myeloid/NK cell precursor acute leukemia and blastic NK cell lymphoma/leukemia", Leukemia Research, 23, 615 — 624.
  • Jacob, M.C., Chaperot, L., Mossuz, P., Feuillard, J., Valensi, F., Leroux, D., et al. (2003) "CD4 + CD56 + lineage negative malignancies: a new entity developed from malignant early plasmatocytoid dendritic cells", Hematologica, 88, 941 —955.
  • Chan, J.K.C, Jaffe, ES. and Ralfkiaer, E. (2001) Blastic NK-cell lymphoma. In Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumors edited by E.S. Jaffe, N.L. Harris, H. Stein and J.W. Vardiman, pp. 214 — 215. Lyon: IARC Press.
  • Kluin, P.M., Feller, A., Gaulard, P, Jaffe, ES., Meijer, C.J.M., Mfiller-Hermenlink, H.K., et al. (2001) "Peripheral T/NK-cell lymphoma: a report of the IXth Workshop of the European Association for Haematopathology", Histopathology, 38, 250–270.
  • Bayerl, M.G., Rakozy, C.K., Mohamed, A.N., Vo, T.D., Long, M., Eilender, D., et al. (2002) "Blastic natural killer cell lymphoma/ leukemia. A report of seven cases", American Journal of Clinical Pathology, 117, 41 — 50.
  • Ko, Y.H., Kim, S.H. and Ree, H.J. (1998) "Blastic NK-cell lymphoma expressing terminal deoxynucleotidyl transferase with Homer-Wright type pseudorosettes formation", Histopathology, 33, 547–553.
  • Chan, J.K.C., Sin, V.C., Wong, K.F., William, C.S.Ng., Tsang, Y.W., Chan, C.H., et al. (1997) "Nonanasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 59 cases of an uncommon aggressive neoplasm", Blood, 89, 4501 — 4513.
  • Ichinohasama, R., Endoh, K., Ishizawa K., Okuda, M., Kameoka, J., Meguro, K., et al. (1996) "Thymic lymphoblastic lymphoma of committed natural killer cell precursor origin", Cancer, 77, 2592–2603.
  • Kawano S., Tatsumi E., Yoneda, N., Yamaguchi, N., Goji, J., Ito, H., et al. (1995) "Novel leukemic lymphoma with probable derivation from immature stage of natural killer (NK) lineage in an aged patient", Haematological Oncology, 13, 1–11.
  • Khoury, J.D., Medeiros, Li., Manning, J.T., Sulak, L.E., Bueso-Ramos, C. and Jones, D. (2002) "CD56 + TdT + Blastic natural cell tumor of the Skin. A primitive systemic malignancy related to myelomonocytic leukemia", Cancer, 94, 2401 —2408.
  • Kobashi, Y., Nakamura, S. and Sasajima, Y. (1996) "Inconsistent association of Epstein-Barr virus with CD56 (NCAM)-positive angiocentric lymphoma occurring in sites other than the upper and lower respiratory tract", Histopathology, 28, I I I —120.
  • Koita, H., Suzumiya, J., Ohshima, K., Takeshita, M., Kimura, N., Kikuchi, M., et al. (1997) "Lymphoblastic lymphoma expressing natural killer cell phenotype with involvement of the mediastinum and nasal cavity", American Journal of Surgical Pathology, 21, 242–248.
  • Nakamura, S., Koshikawa, T., Yatabe, Y. and Suchi, T. (1998) "Lymphoblastic lymphoma expressing CD56 and TdT", American Journal of Surgical Pathology, 22, 135— 137.
  • Santucci, M., Pimpinelli, N., Massi, D., Kadin, ME., Meijer, CJ., Muller-Hermelink, H.K., et al. (2003) "Cytotoxic/natural killer cell cutaneous lymphomas. Report of the EORTC Cutaneous Lympho-ma Task Force Workshop", Cancer, 97, 610–627.
  • Anargyrou, K., Pateralcis, A., Boutsis, D., Politou, M., Papadhimi-triou, S.I., Siakandaris, M., et al. (2003) "An unusal case of CD4 + CD7 + CD56 + acute leukemia with overlapping features of type 2 dendritic cells (DC2) and myeloid/NK cell precursor acute leukemia", European Journal of Haematology, 71, 294 — 298.
  • Shapiro M., Wasik M.A., Junlcins-Hopkins J.M., Rook, A.H., Vittorio, C.C., Itakura H., et al. (2003) "Complete remission in advanced blastic NK-cell lymphoma/leukemia in elderly patients using the hyper-CVAD regimen", American Journal of Hematology, 74, 46–51.
  • Ozturk, MA., Barista, I., Altundag, M.K., Turker, A., Yalcin, S., Celik, I., et al. (2002) "Modified ESHAP as salvage chemotherapy for recurrent or refractory non-Hodgkin's lymphoma: results of a single-center study of 32 patients. Modified etoposide, methyl-prednisolone, cytarabine and cisplatin", Chemotherapy, 48, 252–258.
  • Scott, A.A., Head, D.R., Kopecky, K.J., Appelbaum, FR., Theil, KS., Greyer, MR., et al. (1994) "HLA-DR-, CD33 +, CD56 +, CD16 — myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3", Blood, 84, 244–255.
  • Emile, J.F., Boulland, ML., Haioun, C., Kanavaros, P., Petrella, T., Delfau-Larue, M.H., et al. (1996) "CD5 — /CD56 + `TCR silent peripheral T cell lymphomas' are natural killer cell lymphomas", Blood, 87, 1466–1473.
  • Falcao, R.P., Garcia, A.B., Marques, MG,. Simoes,. B.P., Fonseca, BA., Rodrigues, ML., et al. (2002) "Blastic CD4 NK cell leukemia/ lymphoma: a distinct clinical entity", Leukemia Research, 26, 803–807.
  • Rakozy, C.K., Mohamed, AN., Vo, T.D., Khatib, G., Long, P.M., Eilender, D., et al. (2001) "CD56 + /CD4 + lymphomas and leukemias are morphologically, immunophenotypically, cytogeneti-cally and clinically diverse", American Journal of Clinical Pathology, 116, 168 — 176.
  • Suzuki, R., Yamamoto, K. and Seto, M. (1997) "CD7 ± and CD56+ Myeloid/Natural killer cell precursor acute leukemia: a distinct haematolymphoid disease entity", Blood, 90, 2417–2428.
  • Touahri, T., Belaouni, H., Mossafa, H., Pulik, M., Bourguigna, L., Ibbora, C., et al. (2002) "Agranular CD4 + /CD56 + positive cutaneous neoplasm", Leukemia Lymphoma, 43, 1475 —1479.
  • Kanavaros, P., Boulland, ML., Petit, B., Arnulf, B. and Gaulard, P. (2000) "Expression of cytotoxic proteins in T and NK-cell lymphomas. Association with extranodal site, NK or Ty5 origin, anaplastic morphology and CD30 molecule expression", Leukemia and Lymphoma, 38, 317–326.
  • Kanavaros, P., Briere, J., Lescs, M.C. and Gaulard, P. (1996) "Epstein-Barr Virus in non-Hodgkin's lymphomas of the upper respiratory tract: association with sinonasal localization and expression of NK and/or T/cell antigens by tumor cells". Journal of Pathology, 178, 297 — 302.
  • Natkunam, Y., Smoller, BR., Zehnder, J.L., Dorfman, R.F. and Warnke, R.A. (1999) "Aggressive Cutaneous NK and NK-like T-cell lymphomas: clinicopathologic, immunohistochemical and mo-lecular analysis of 12 cases", American Journal of Surgical Pathology, 23, 571–581.
  • Mraz-Gernhard, S., Natkunam, Y., Hoppe, R.T., LeBoit, P., Kohler, S. and Kim, Y.H. (2001) "Natural killer/natural killer-like T-cell lymphoma, CD56 +, presenting in the skin: an increasingly recognized entity with an aggressive course", Journal of Clinical Oncology, 19, 2179–2188.
  • DiGiuseppe, JA., Louie, D.C., Williams, J.E., Miller, D.T., Griffin, C.A., Mann, R.B., et al. (1997) "Blastic natural killer cell leukemia/ lymhoma: a clinicopathological study", American Journal of Surgical Pathology, 21, 1223 — 1230.
  • Leroux, D., Mugneret, F., Callanan, M., Radford-Weiss, I, Dastugue, N., Feuillard, J., et al. (2002) "CD4 +, CD56 +, DC2 acute leukemia is characterized by recurrent clonal chromosomal changes affecting 6 major targets: a study of 21 cases by the Groupe Francais de Cytogenetique Hematologique", Blood, 99, 4154 —4159.
  • Picker, Li., Michie, S.A., Rott, L.S. and Butcher, E.C. (1990) "A unique phenotype of skin associated lymphocytes in humans: preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites", American Journal of Pathology, 136, 1053–1068.
  • Schechner, J.S, Edelson, R.L., McNiff, J.M., Heald, P.W. and Pober, J.S. (1999) "Integrins a4b7 and aEb7 are expressed on epidermotropic T cells in cutaneous T cell lymphoma and spongiotic dermatitis", Laboratory Investigation, 79, 601–607.
  • Hirata, T., Furie, B.C. and Furie, B. (2002) "P-, E-, and L-selectin mediate migration of activated CD8+ T-lymphocytes into inflamed skin", Journal of Immunology, 169, 4307–4313.
  • Tsuchiyama, J., Yoshino, T., Toba, K., Harada, N., Nishiuchi, R., Akagi, T., et al. (2002) "Induction and characterization of cutaneous lymphocyte antigen on natural killer cells", British Journal of Haematology, 118, 654–662.
  • Plum, J., De Smedt, M., Verhasselt, B., Offner, F., Kerre, T., Vanhecke, D., et al. (1999) "In vitro intrathymic differentiation kinetics of human fetal liver CD34+ CD38— progenitors reveals a phenotypically defined dendritic/T-NK precursor split", Journal of Immunology, 162, 60–68.
  • Petrella, T., Comeau, MR., Maynadie, M., Couillault, G., De Muret, A., Maliszewslci, CR., et al. (2002) "Agranular CD4 + CD56 + haematodermic neoplasm' (blastic NK-cell lymphoma) originates from a population of CD56 + precursor cells related to plasmacytoid monocytes", American Journal of Surgical Pathology, 26, 852–862.
  • Herling, M., Teitell, MA., Shen, R.R., Medeiros, Li. and Jones D. (2003) "TCL1 expression in plasmacytoid dendritic cells (DC2) and the related CD4 + CD56 + blastic tumors of the skin", Blood, 101, 5007 — 5009.
  • Kameoka, J., Ichinohasama, R., Tanaka, M., Miura, I., Tomiya, Y., Takahashi, S., et al. (1998) "A cutaneous Agranular CD2 — CD4 — CD56 + 'Lymphoma—, American Journal of Clinical Pathology, 110, 478–488.
  • Karube K., Ohshima K., Tsuchiya T., Yamaguchi T., Suefuji H., Suzumiya J., et al. (2003) "Non-B, non-T neoplasms with lymphoblast morphology: further clarification and classification", American Journal of Surgical Pathology, 27, 1366 — 1374.

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