Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells

References

• Ribas C, Colleoni G W. Advances in the treatment of multiple myeloma: the role of thalidomide. Leuk Lymphoma 2003; 44: 291–298
   PubMed Web of Science ®Google Scholar
• Sirohi B, Powles R. Multiple myeloma. Lancet 2004; 363: 875–887
   PubMed Web of Science ®Google Scholar
• Mitsiades N, Mitsiades C S, Richardson P G, Poulaki V, Tai Y T, Chauhan D, et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 2003; 101: 2377–2380
   PubMed Web of Science ®Google Scholar
• Shapiro-Shelef M, Calame K. Plasma cell differentiation and multiple myeloma. Curr Opin Immunol 2004; 16: 226–234
   PubMed Web of Science ®Google Scholar
• Oyadomari S, Araki E, Mori M. Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells. Apoptosis 2002; 7: 335–345
   PubMed Web of Science ®Google Scholar
• Rutkowski D T, Kaufman R J. All roads lead to ATF4. Dev in Cell 2003; 4: 442–444
   PubMed Web of Science ®Google Scholar
• Rutkowski D T, Kaufman R J. A trip to the ER: coping with stress. Trends in Cell Biol 2004; 14: 20–28
   PubMed Web of Science ®Google Scholar
• Ferri K F, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001; 3: E255–E263
   PubMed Web of Science ®Google Scholar
• Yoshida H, Matsui T, Hosokawa N, Kaufman R J, Nagata K, Mori K. A time-dependent phase shift in the mammalian unfolded protein response. Dev in Cell 2003; 4: 265–271
   PubMed Web of Science ®Google Scholar
• Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, et al. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Devel 2002; 16: 452–466
   PubMed Web of Science ®Google Scholar
• Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Difference 2004; 11: 381–389
   PubMed Web of Science ®Google Scholar
• Iwakoshi N N, Lee A H, Glimcher L H. The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev 2003; 194: 29–38
   PubMed Web of Science ®Google Scholar
• Melnick J, Aviel S, Argon Y. The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains. J Biol Chem 1992; 267: 21303–21306
   PubMed Web of Science ®Google Scholar
• Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001; 107: 881–891
   PubMed Web of Science ®Google Scholar
• Shen X, Ellis R E, Lee K, Liu C Y, Yang K, Solomon A, et al. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 2001; 107: 893–903
   PubMed Web of Science ®Google Scholar
• Calfon M, Zeng H, Urano F, Till J H, Hubbard S R, Harding H P, et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002; 415: 92–96
   PubMed Web of Science ®Google Scholar
• Reimold A M, Iwakoshi N N, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese E M, et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature 2001; 412: 300–307
   PubMed Web of Science ®Google Scholar
• Iwakoshi N N, Lee A H, Vallabhajosyula P, Otipoby K L, Rajewsky K, Glimcher L H. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol 2003; 4: 321–329
   PubMed Web of Science ®Google Scholar
• Munshi N C, Hideshima T, Carrasco D, Shammas M, Auclair D, Davies F, et al. Identification of genes modulated in multiple myeloma using genetically identical twin samples. Blood 2004; 103: 1799–1806
   PubMed Web of Science ®Google Scholar
• Lee A H, Iwakoshi N N, Anderson K C, Glimcher L H. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci USA 2003; 100: 9946–9951
   PubMed Web of Science ®Google Scholar
• Durie B G, Salmon S E. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer 1975; 36: 842–854
   PubMed Web of Science ®Google Scholar
• Uneda S, Hata H, Matsuno F, Harada N, Mitsuya Y, Kawano F, Mitsuya H. Macrophage inflammatory protein-1 alpha is produced by human multiple myeloma (MM) cells and its expression correlates with bone lesions in patients with MM. Br J Haematol 2003; 120: 53–55
   PubMed Web of Science ®Google Scholar
• Ohtsuki T, Yawata Y, Wada H, Sugihara T, Mori M, Namba M. Two human myeloma cell lines, amylase-producing KMS-12-PE and amylase-non-producing KMS-12-BM, were established from a patient, having the same chromosome marker, t(11;14)(q13;q32). Br J Haematol 1989; 73: 199–204
   PubMed Web of Science ®Google Scholar
• Ikeyama S, Nakagawa S, Arakawa M, Sugino H, Kakinuma A. Purification and characterization of IgE produced by human myeloma cell line, U266. Mol Immunol 1986; 23: 159–167
   PubMedGoogle Scholar
• Matsuoka Y, Moore G. E., Yagi Y, Pressman D. Production of free light chains of immunoglobulin by a hematopoietic cell line derived from a patient with multiple myeloma. Proceedings of the Society of Exp Biol Med 1967; 125: 1246
   PubMed Web of Science ®Google Scholar
• Hata H, Matsuzaki H, Sonoki T, Takemoto S, Kuribayashi N, Nagasaki A, Takatsuki K. Establishment of a CD45-positive immature plasma cell line from an aggressive multiple myeloma with high serum lactate dehydrogenase. Leukemia 1994; 8: 1768–1773
   PubMed Web of Science ®Google Scholar
• Togawa A, Inoue N, Miyamoto K, Hyodo H, Namba M. Establishment and characterization of a human myeloma cell line (KMM-1). Int J Cancer 1982; 29: 495–500
   PubMed Web of Science ®Google Scholar
• Epstein M A, Achong B G, Barr Y M, Zajac B, Henle G, Henle W. Morphological and virological investigations on cultured Burkitt tumor lymphoblasts (strain Raji). J Nat Cancer Inst 1966; 37: 547–559
   PubMed Web of Science ®Google Scholar
• Sonoki T, Matsuzaki H, Miyamoto K, Taniwaki M, Yoshino T, Hata H, et al. Establishment of the novel B acute lymphoblastic leukemia (FAB L3) cell line KHM-10B with a 13q34 abnormality and constitutive expression of c-myc and max during cell cycle. Leukemia 1995; 9: 2093–2099
   PubMed Web of Science ®Google Scholar
• Collins S J, Ruscetti F W, Gallagher R E, Gallo R C. Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proc Nat Acad Sci USA 1978; 75: 2458–2462
   PubMed Web of Science ®Google Scholar
• Chomczynski P NS. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analyt Biochemis 1987; 162: 156–159
   PubMed Web of Science ®Google Scholar
• Gotoh T, Mori M. Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells. J Cell Biol 1999; 144: 427–434
   PubMed Web of Science ®Google Scholar
• Reddy R K, Mao C, Baumeister P, Austin R C, Kaufman R J, Lee A S. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biolog Chem 2003; 278: 20915–20924
   PubMed Web of Science ®Google Scholar
• Ma Y, Hendershot L M. The stressful road to antibody secretion. Nat Immunol 2003; 4: 310–311
   PubMedGoogle Scholar
• Matsumoto M, Minami M, Takeda K, Sakao Y, Akira S. Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Letters 1996; 395: 143–147
   PubMed Web of Science ®Google Scholar
• McCullough K D, Martindale J L, Klotz L O, Aw T Y, Holbrook N J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 2001; 21: 1249–1259
   PubMed Web of Science ®Google Scholar
• Anether G, Tinhofer I, Senfter M, Greil R. Tetrocarcin-A—induced ER stress mediates apoptosis in B-CLL cells via a Bcl-2-independent pathway. Blood 2003; 101: 4561–4568
   PubMed Web of Science ®Google Scholar
• Wen X Y, Stewart A K, Sooknanan R R, Henderson G, Hawley T S, Reimold A M, et al. Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells. Int J Oncol 1999; 15: 173–178
   PubMed Web of Science ®Google Scholar
• Anagnostopoulos A, Gika D, Hamilos G, Zervas K, Zomas A, Pouli A, et al. Treatment of relapsed/refractory multiple myeloma with thalidomide-based regimens: identification of prognostic factors. Leuk Lymphoma 2004; 45: 2275–2279
   PubMed Web of Science ®Google Scholar
• Harding H P, Zhang Y, Zeng H, Novoa I, Lu P D, Calfon M, et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 2003; 11: 619–633
   PubMed Web of Science ®Google Scholar
• Jiang H Y, Wek S A, McGrath B C, Lu D, Hai T, Harding H P, et al. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol 2004; 24: 1365–1377
   PubMed Web of Science ®Google Scholar
• Okada T, Haze K, Nadanaka S, Yoshida H, Seidah N G, Hirano Y, et al. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J Biol Chem 2003; 278: 31024–31032
   PubMed Web of Science ®Google Scholar