Evidence for an association of high levels of endogenous Acetyl-Ser-Asp-Lys-Pro, a potent mediator of angiogenesis, with acute myeloid leukemia development

References

• Lenfant M, Wdzieczak-Bakala J, Guittet E, Prome J C, Sotty D, Frindel E. Inhibitor of hematopoietic pluripotent stem cell proliferation: purification and determination of its structure. Proc Natl Acad Sci USA 1989; 86: 779–782
   PubMed Web of Science ®Google Scholar
• Bonnet D, Lemoine F M, Pontvert-Delucq S, Baillou C, Najman A, Guigon M. Direct and reversible inhibitory effect of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Seraspenide) on the growth of human CD34+ subpopulations in response to growth factors. Blood 1993; 82: 3307–3314
   PubMed Web of Science ®Google Scholar
• Liu J M, Lawrence F, Kovacevic M, Bignon J, Papadimitriou E, Lallemand J Y, et al. The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo. Blood 2003; 101: 3014–3020
   PubMed Web of Science ®Google Scholar
• Wang D, Carretero O A, Yang X Y, Rhaleb N E, Liu Y H, Liao T D, et al. N-acetyl-seryl-aspartyl-lysyl-proline stimulates angiogenesis in vitro and in vivo. Am J Physiol Heart Circ Physiol 2004; 287: H2099–H2105
   PubMed Web of Science ®Google Scholar
• Waeckel L, Bignon J, Liu J M, Markovits D, Ebrahimian T G, Vilar J, et al. The tetrapeptide AcSDKP induces post-ischemic neovascularization through monocyte chemoattractant protein-1 signaling. Arterioscler Thromb Vasc Biol 2006; 26: 773–779
   PubMed Web of Science ®Google Scholar
• Fromes Y, Liu J M, Kovacevic M, Bignon J, Wdzieczak-Bakala J. The tetrapeptide AcSDKP improves skin flap survival and accelerates wound healing. Wound Rep Reg 2006, in press
   PubMed Web of Science ®Google Scholar
• Carmeliet P, Jain R K. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249–257
   PubMed Web of Science ®Google Scholar
• Ribatti D, Scavelli C, Roccaro A M, Crivellato E, Nico B, Vacca A. Hematopoietic cancer and angiogenesis. Stem Cells Dev 2004; 13: 484–495
   Google Scholar
• De Raeve H, Van Marck E, Van Camp B, Vanderkerken K. Angiogenesis and the role of bone marrow endothelial cells in haematological malignancies. Histol Histopathol 2004; 19: 935–950
   PubMed Web of Science ®Google Scholar
• Hepburn M, Doherty I, Briscoe C, Riches A. Transplantation and morphological studies of primary and passaged murine radiation-induced myeloid leukaemias. Leukaemia Res 1987; 11: 1001–1009
   PubMed Web of Science ®Google Scholar
• Gaulier A, Fourcade C, Szekeres G, Pulik M. Bone marrow one step fixation-decalcification in Lowy FMA solution: an immunohistological and in situ hybridization study. Pathol Res Pract 1994; 190: 1149–1161
   PubMed Web of Science ®Google Scholar
• Hussong J W, Rodgers G M, Shami P J. Evidence of increased angiogenesis in patients with acute myeloid leukemia. Blood 2000; 95: 309–313
   PubMed Web of Science ®Google Scholar
• Aguayo A, Kantarjian H, Manshouri T, Gidel C, Estey E, Thomas D, et al. Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. Blood 2000; 96: 2240–2245
   PubMed Web of Science ®Google Scholar
• Huang W Q, Wang Q R. Bone marrow endothelial cells secrete thymosin beta4 and AcSDKP. Exp Hematol 2001; 29: 12–18
   PubMed Web of Science ®Google Scholar
• Wdzieczak-Bakala J, Grillon C, Robinson S, Riches A, Carde P, Lenfant M. Catabolism of the tetrapeptide N-Ac-Ser-Asp-Lys-Pro (AcSDKP), an inhibitor of hematopoietic stem cell (CFU-S) proliferation, following in vitro incubation with hematopoietic tissues from normal and leukemic mice. Bull Cancer 1993; 80: 391–396
   PubMed Web of Science ®Google Scholar
• Podar K, Anderson K C. The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications. Blood 2005; 105: 1383–1395
   PubMed Web of Science ®Google Scholar
• Bieker R, Padro T, Kramer J, Steins M, Kessler T, Retzlaff S, et al. Overexpression of basic fibroblast growth factor and autocrine stimulation in acute myeloid leukemia. Cancer Res 2003; 63: 7241–7246
   PubMed Web of Science ®Google Scholar
• Santos S C, Dias S. Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways. Blood 2004; 103: 3883–3889
   PubMed Web of Science ®Google Scholar
• Fiedler W, Graeven U, Ergun S, Verago S, Kilic N, Stockschlader M, et al. Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. Blood 1997; 89: 1870–1875
   PubMed Web of Science ®Google Scholar
• Boutonnat J, Faussat A M, Marie J P, Bignon J, Wdzieczak-Bakala J, Barbier M, et al. Usefulness of PKH fluorescent labelling to study leukemic cell proliferation with various cytostatic drugs or acetyl tetrapeptide – AcSDKP. BMC Cancer 2005; 5: 120–134
   PubMed Web of Science ®Google Scholar
• Bonnet D, Cesaire R, Lemoine F, Aoudjhane M, Najman A, Guigon M. The tetrapeptide AcSDKP, an inhibitor of the cell-cycle status for normal human hematopoietic progenitors, has no effect on leukemic cells. Exp Hematol 1992; 20: 251–255
   PubMed Web of Science ®Google Scholar
• Cashman J D, Eaves A C, Eaves C J. The tetrapeptide AcSDKP specifically blocks the cycling of primitive normal but not leukemic progenitors in long-term culture: evidence for an indirect mechanism. Blood 1994; 84: 1534–1542
   PubMed Web of Science ®Google Scholar
• Liozon E, Pradelles P, Venot J, Rigaud M, Cransac M, Bordessoule D, et al. Serum levels of a negative regulator of cell proliferation (AcSDKP) are increased in certain human haemopathies. Leukemia 1993; 7: 808–812
   PubMed Web of Science ®Google Scholar
• Cha H J, Jeong M J, Kleinman H K. Role of thymosin beta 4 in tumor metastasis and angiogenesis. J Natl Cancer Inst 2003; 95: 1674–1680
   PubMed Web of Science ®Google Scholar
• Shimamura R, Kudo J, Kondo H, Dohmen K, Gondo H, Okamura S, et al. Expression of the thymosin beta 4 gene during differentiation of hematopoietic cells. Blood 1990; 76: 977–984
   PubMed Web of Science ®Google Scholar
• Lenfant M, Grillon C, Rieger K J, Sotty D, Wdzieczak-Bakala J. Formation of acetyl-Ser-Asp-Lys-Pro, a new regulator of the hematopoietic system, through enzymatic processing of thymosin beta 4. Ann NY Acad Sci 1991; 628: 115–125
   PubMed Web of Science ®Google Scholar
• Cavasin M A, Rhaleb N E, Yang X P, Carretero O A. Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP. Hypertension 2004; 43: 1140–1145
   PubMed Web of Science ®Google Scholar
• Perez-Atayde A R, Sallan S E, Tedrow U, Connors S, Allred E, Folkman J. Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. J Pathol 1997; 150: 815–821
   Web of Science ®Google Scholar
• Vacca A, Ria R, Semeraro F, Merchionne F, Coluccia M, Boccarelli A, et al. Endothelial cells in the bone marrow of patients with multiple myeloma. Blood 2003; 102: 3340–3348
   PubMed Web of Science ®Google Scholar