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Commentary

MTHFR polymorphisms and the development of acute leukemia: Does it really matter?

& , MD
Pages 2002-2003 | Published online: 01 Jul 2009

References

  • Blount B C, Mack M M, Wehr C M, MacGregor J T, Hiatt R A, Wang G, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 1997; 94(7)3290–3295
  • Robien K, Ulrich C M. 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview. Am J Epidemiol 2003; 157(7)571–582
  • Skibola C F, Smith M T, Kane E, Roman E, Rollinson S, Cartwright R A, et al. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA 1999; 96(22)12810–12815
  • Wiemels J L, Smith R N, Taylor G M, Eden O B, Alexander F E, Greaves M F. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA 2001; 98(7)4004–4009
  • Zanrosso C W, Hatagima A, Emerenciano M, Ramos F, Figueiredo A, Felix T M, et al. The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population. Leuk Res 2006; 30(4)477–481
  • Chiusolo P, Reddiconto G, Cimino G, Sica S, Fiorini A, Farina G, et al. Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population. Haematologica 2004; 89(2)139–144
  • Oliveira E, Alves S, Quental S, Ferreira F, Norton L, Costa V, et al. The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal. J Pediatr Hematol Oncol 2005; 27(8)425–429
  • Schnakenberg E, Mehles A, Cario G, Rehe K, Seidemann K, Schlegelberger B, et al. Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population. BMC Med Genet 2005; 6: 23
  • de Costa Ramos F J, Tereza M, Muniz C, Silva V C, Araújo M, Leite E P, et al. Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian children. Leuk Lymphoma 2006; 47: 2070–2075

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