95
Views
11
CrossRef citations to date
0
Altmetric
Original

Combination immunotherapy with anti-CD20 and anti-HLA-DR monoclonal antibodies induces synergistic anti-lymphoma effects in human lymphoma cell lines

, , MD, , , &
Pages 944-956 | Received 06 Dec 2006, Accepted 09 Feb 2007, Published online: 01 Jul 2009

References

  • Smalley R V, Weller E, Hawkins M J, Oken M M, O'Connell M J, Haase-Statz S, et al. Final analysis of the ECOG I-COPA trial (E6484) in patients with non-Hodgkin's lymphoma treated with interferon alfa (IFN-a2a) plus an anthracycline-based induction regimen. Leukemia 2001; 15: 1118–1122
  • Weiner G J, Link B K. Monoclonal antibody therapy of B cell lymphoma. Exp Opin Biol Ther 2004; 4: 375–385
  • Harris M. Monoclonal antibodies as therapeutic agents for cancer. Lancet 2004; 5: 292–302
  • McLaughlin P, Grillo-Lopez A J, Link B K, Levy R, Czuczman M S, Williams M E, et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol 1998; 16: 2825–2833
  • Rose A L, Smith B E, Maloney D G. Glucocorticoids and rituximab in vitro: synergistic direct antiproliferative and apoptotic effects. Blood 2002; 100: 1765–1773
  • Taji H, Kagami Y, Okada Y, Andou M, Nishi Y, Saito H, et al. Growth inhibition of CD20-positive B lymphoma cell lines by IDEC-C2B8 anti-CD20 monoclonal antibody. Jap J Cancer Res 1998; 89: 748–756
  • van der Kolk L E, de Haas M, Grillo-Lopez A J, Baars J W, van Oers M HJ. Analysis of CD20-dependent cellular cytotoxicity by G-CSF-stimulated neutrophils. Leukemia 2002; 16: 693–699
  • Golay J, Zaffaroni L, Vaccari T, Lazzari M, Borleri G, Bernasconi S, et al. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituxmab in vitro: CD55 and CD59 regulate complement-mediated cell lysis. Blood 2000; 95: 3900–3908
  • Igarashi T, Ohtsu T, Fujii H, Sasaki Y, Morishima Y, Ogura M, et al. Re-treatment of relapsed indolent B-cell lymphoma with rituximab. Int J Hematol 2001; 73: 213–221
  • Smith M R. Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance. Oncogene 2003; 22: 7359–7368
  • Czuczman M S, Grillo-Lopez A J, White C A, Saleh M, Gordon L, LoBuglio A F, et al. Treatment of patients with low-grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy. J Clin Oncol 1999; 17: 268–276
  • Czuczman M S. Immunochemotherapy in indolent non-Hodgkin's lymphoma. Semin Oncol 2002; 29(Suppl 6)11–17
  • Coiffer B, Lepage E, Briere J, Herbrecht R, Tilly H, Bouabdallah R, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002; 346: 235–242
  • Ghetie M A, Bright H, Vitetta E S. Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin. Blood 2001; 97: 1392–1398
  • Di Gaetano N, Xiao Y, Erba E, Bassan R, Rambaldi A, Golay J, et al. Synergism between fludarabine and rituximab revealed in a follicular lymphoma cell line resistant to the cytotoxic activity of either drug alone. Br J Haematol 2001; 114: 800–809
  • Chow K U, Sommerlad W D, Boehrer S, Schneider B, Seipelt G, Rummel M J, et al. Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases. Haematologica 2002; 87: 33–43
  • Demidem A, Lam T, Alas S, Hariharan K, Hanna N, Bonavida B. Chimeric anti-CD20 (IDEC-C2B8) monoclonal antibody sensitizes a B cell lymphoma cell line to cell killing by cytotoxic drugs. Cancer Biother Radiopharm 1997; 12: 177–186
  • Magni M, Di Nicola M, Devizzi L, Matteucci P, Lombardi F, Gandola L, et al. Successful in vivo purging of CD34-containing peripheral blood harvests in mantle-cell and indolent lymphoma: evidence for a role of both chemotherapy and rituximab infusion. Blood 2000; 96: 864–869
  • O'Brien S, Kantarjian H, Thomas D A, Giles F J, Freireich E J, Cortes J, et al. Rituximab dose-escalation trial in chronic lymphocytic leukemia. J Clin Oncol 2001; 19: 2165–2170
  • Piro L D, White C A, Grillo-Lopez A J, Janakiraman N, Saven A, Beck T, Varns C, et al. Extended rituximab (anti-CD20 monoclonal antibody) therapy for relapsed or refractory low-grade or follicular non-Hodgkin's lymphoma. Ann Oncol 1999; 10: 655–661
  • Hegde U, White T, Stetler-Stevenson M, Marti G, Janik J, Pittaluga S, et al. Phase I study of combination rituximab (CD20) and apolizumab (Hu1D10) monoclonal antibody therapy in previously treated B-cell lymphoma and chronic lymphocytic leukemia [abstract]. Blood 2002; 100(Suppl 1)358a
  • Szollosi J, Horejsi V, Bene L, Angelisova P, Damjanovich S. Supramolecular complexes of MHC Class I, MHC Class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. J Immunol 1996; 157: 2939–2946
  • Nabhan C, Tallman M, Riley M, Fitzpatrick J, Gordon L, Gartenhaus R, et al. Phase I study of rituximab and Campath-1H in patients with relapsed or refractory chronic lymphocytic leukemia [abstract]. Blood 2001; 98: 365a
  • Faderl S, Thomas D A, O'Brien S, Giles F, Koller C, Beran M, et al. An exploratory study of the combination of monoclonal antibodies Campath-1H and rituximab in the treatment of CD52- and CD20- positive chronic lymphoid disorders [abstract]. Blood 2001; 98: 365a
  • Strauss S J, Morschhauser F, Rech J, Repp R, Solal-Celigny P, Zinzani P L, et al. Multicenter phase II trial of immunotherapy with the humanized anti-CD22 antibody, epratuzumab, in combination with rituximab, in refractory or recurrent non-Hodgkin's lymphoma. J Clin Oncol 2006; 24: 3880–3886
  • Hu E, Epstein A L, Naeve G S, Gill I, Martin S, Sherrod A, et al. A phase 1a clinical trial of Lym-1 monoclonal antibody serotherapy in patients with refractory B cell malignancies. Hematol Oncol 1989; 7: 155–166
  • Liu C, DeNardo G, Tobin E, DeNardo S. Antilymphoma effects of anti-HLA-DR and CD20 monoclonal antibodies (Lym-1 and rituximab) on human lymphoma cells. Cancer Biother Radiopharm 2004; 19: 545
  • Epstein A L, Marder R J, Winter J N, Stathopoulos E, Chen F M, Parker J W, et al. Two new monoclonal antibodies, Lym-1 and Lym-2, reactive with human-B-lymphocytes and derived tumors, with immunodiagnostic and immunotherapeutic potential. Cancer Res 1987; 47: 830–840
  • Ottonello L, Morone P, Dapino P, Dallegri F. Monoclonal Lym-1 antibody-dependent lysis of B-lymphoblastoid tumor targets by human complement and cytokine-exposed mononuclear and neutrophilic polymorphonuclear leukocytes. Blood 1996; 87: 5171–5178
  • Hu E, Glasky M S, Yun A, Alauddin M, Hornick J L, Khawli L A, et al. A human-mouse chimeric Lym-1 monoclonal antibody with specificity for human lymphomas expressed in a baculovirus system. Hum Antibod Hybridomas 1995; 6: 57–67
  • Kostelny S A, Link B K, Tso J Y, Vasquez M, Jorgensen B H, Wang H, et al. Humanization and characterization of the anti-HLA-DR antibody 1D10. Int J Cancer 2001; 93: 556–565
  • Stein R, Zhengxing Q, Chen S, Solis D, Hansen H J, Goldenberg D M. Characterization of a humanized IgG4 anti-HLA-DR monoclonal antibody that lacks effector cell functions but retains direct antilymphoma activity and increases potency of rituximab. Neoplasia 2006; 108: 2736–2744
  • Press O W, Farr A G, Borroz K I, Anderson S K, Martin P L. Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies. Cancer Res 1989; 49: 4906–4912
  • Leveille C, Cataigne J G, Charron D, Al-Daccak R. MHC class II isotype-specific signaling complex on human B cells. Eur J Immunol 2002; 32: 2282–2291
  • Leveille C, Al-Daccak R, Mourad W. CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines. Eur J Immunol 1999; 29: 65–74
  • Rose L M, Deng C T, Scott S, Xiong C Y, Lamborn K R, Gumerlock P H, et al. Critical Lym-1 binding residues on polymorphic HLA-DR molecules. Mol Immunol 1999; 36: 789–797
  • Fell H P, Gayle M A, Yelton D, Lipsich L, Schieven G L, Marken J S, et al. Chimeric L6 anti-tumor antibody. Genomic construction, expression, and characterization of the antigen binding site. J Biol Chem 1992; 267: 15552–15558
  • Friberger P, Knos M, Mellstam L. Endotoxin and Their Detection with the Limulus Test. Alan R. Liss, New York 1982; 195
  • Mariani A R, Columbaro M, Zauli G, Zamai L, Luchetti F, Gobbi P, et al. Lineage-related susceptibility of human hemopoietic cell lines to apoptosis. Anat Rec 1999; 254: 1–6
  • Elsasser D, Valerius T, Repp R, Weiner G J, Deo Y, Kalden J R, et al. HLA Class II as potential target antigen on malignant B cells for therapy with bispecific antibodies in combination with granulocyte colony-stimulating factor. Blood 1996; 87: 3803–3812
  • Wurflein D, Dechant M, Stockmeyer B, Tutt A L, Hu P, Repp R, et al. Evaluating antibodies for their capacity to induce cell-mediated lysis of malignant B cells. Cancer Res 1998; 58: 3051–3058
  • Berenbaum M C. What is synergy?. Pharmacol Rev 1989; 41: 93–141
  • Stein R, Qu Z, Chen S, Rosario A, Shi V, Hayes M, et al. Characterization of a new humanized anti-CD20 monoclonal antibody, IMMU-106, and its use in combination with the humanized anti-CD22 antibody, epratuzumab, for the therapy of non-Hodgkin's lymphoma. Clin Cancer Res 2004; 10: 2868–2878
  • Henderson E H, Samaha R J. Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies. Cancer Res 1969; 29: 2272–2280
  • Golay J, Lazzari M, Facchinetti V, Bernasconi S, Borleri G, Barbui T, et al. CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59. Blood 2001; 98: 3383–3389
  • Ginaldi L, De Martinis M, Matutes E, Farahat N, Morilla R, Catovsky D. Levels of expression of CD19 and CD20 in chronic B cell leukaemias. J Clin Pathol 1998; 51: 364–369
  • Huh Y O, Keating M, Saffer H L, Jilani I, Lerner S, Albitar M. Higher levels of surface CD20 expression on circulating lymphocytes compared with bone marrow and lymph nodes in B-cell chronic lymphocytic leukemia. Am J Clin Pathol 2001; 116: 437–443
  • Jilani I, O'Brien S, Manshuri T, Thomas D A, Thomazy V A, Imam M, et al. Transient down-modulation of CD20 by rituximab in patients with chronic lymphocytic leukemia. Blood 2003; 102: 3514–3520
  • Davis T A, Czerwinski D K, Levy R. Therapy of B-cell lymphoma with anti-CD20 antibodies can result in the loss of CD20 antigen expression. Clin Cancer Res 1999; 5: 611–615
  • Schmitz K, Brugger W, Weis B, Kaiserling E, Kanz L. Clonal selection of CD20-negative non-Hodgkin's lymphoma cells after treatment with anti-CD20 antibody rituximab. Br J Haematol 1999; 106: 569–674
  • Byrd J C, Murphy T, Howard R S, Lucas M S, Goodrich A, Park K, et al. Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol 2001; 19: 2153–2164
  • Semac I, Palomba C, Kulangara K, Klages N, van Echten-Deckert G, Borisch B, et al. Anti-CD20 therapeutic antibody rituximab modifies the functional organization of rafts/microdomains of B lymphoma cells. Cancer Res 2003; 63: 534–540
  • Deans J P, Robbins S M, Polyak M J, Savage J A. Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment. J Biol Chem 1998; 273: 344–348
  • Shan D, Ledbetter J A, Press O W. Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells. Cancer Immunol Immunother 2000; 48: 673–683
  • Hofmeister J K, Cooney D, Coggeshall K. Clustered CD20 induced apoptosis: Src-family kinase, the proximal regulator of tyrosine phosphorylation, calcium influx, and caspase 3-dependent apoptosis. Blood Cell Mol Dis 2000; 26: 133–143
  • Huby R, Dearman R J, Kimber I. Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. J Biol Chem 1999; 274: 22591–22596
  • Bouillon M, El Fakhry Y, Girouard J, Khalil H, Thibodeau J, Mourad W. Lipid raft-dependent and -independent signaling through HLA-DR molecules. J Biol Chem 2003; 278: 7099–7107
  • Bruenke J, Barbin K, Kunert S, Lang P, Pfeiffer M, Stieglmaier K, et al. Effective lysis of lymphoma cells with a stabilized bi-specific single chain Fv antibody against CD19 and FcgammaRIII (CD16). Br J Haematol 2005; 130: 218–228
  • Bruenke J, Fischer B, Barbin K, Schreiter K, Wachter Y, Mahr K, et al. A recombinant bispecific single-chain Fv antibody against HLA class II and FcgammaRIII (CD16) triggers effective cell lysis of lymphoma cells. Br J Haematol 2004; 125: 167–179
  • Berinstein N L, Grillo-Lopez A J, White C A, Bence-Bruckler I, Maloney D, Czuczman M, et al. Association of serum rituximab (IDEC-C2B8) concentration and anti-tumor response in the treatment of recurrent low-grade or follicular non-Hodgkin's lymphoma. Ann Oncol 1998; 9: 995–1001

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.