Application of BIOMED-2 clonality assays to formalin-fixed paraffin embedded follicular lymphoma specimens: Superior performance of the IGK assays compared to IGH for suboptimal specimens

References

• Evans P A, Pott C, Groenen P J, Salles G, Davi F, Berger F, et al. Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia 2007; 21: 207–214
   PubMed Web of Science ®Google Scholar
• van Dongen J J, Langerak A W, Bruggemann M, Evans P A, Hummel M, Lavender F L, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17: 2257–2317
   PubMed Web of Science ®Google Scholar
• van Krieken J H, Langerak A W, San Miguel J F, Parreira A, Smith J L, Morgan G M, et al. Clonality analysis for antigen receptor genes: preliminary results from the Biomed-2 concerted action PL 96-3936. Hum Pathol 2003; 34: 359–361
   PubMed Web of Science ®Google Scholar
• van Krieken J H, Langerak A W, San Miguel J F, Parreira A, Smith J L, Morgan G M, et al. Clonality analysis for antigen receptor genes: preliminary results from the Biomed-2 concerted action PL 96-3936. Hum Pathol 2003; 34: 359–361
   PubMed Web of Science ®Google Scholar
• Srinivasan M, Sedmak D, Jewell S. Effect of fixatives and tissue processing on the content and integrity of nucleic acids. Am J Pathol 2002; 161: 1961–1971
   PubMed Web of Science ®Google Scholar
• McClure R F, Kaur P, Pagel E, Ouillette P D, Holtegaard C E, Treptow C L, et al. Validation of immunoglobulin gene rearrangement detection by PCR using commercially available BIOMED-2 primers. Leukemia 2006; 20: 176–179
   PubMed Web of Science ®Google Scholar
• Zhu D, McCarthy H, Ottensmeier C H, Johnson P, Hamblin T J, Stevenson F K. Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma. Blood 2002; 99: 2562–2568
   PubMed Web of Science ®Google Scholar
• Catherwood M A, Gonzalez D, Patton C, Dobbin E, Venkatraman L, Alexander H D. Improved clonality assessment in germinal centre/post germinal centre non-Hodgkin's lymphomas with high rates of somatic hypermutation. J Clin Pathol June, 2006, (Epub ahead of print)
   Web of Science ®Google Scholar
• Diss T C, Liu H X, Du M Q, Isaacson P G. Improvements to B cell clonality analysis using PCR amplification of immunoglobulin light chain genes. Mol Pathol 2002; 55: 98–101
   PubMedGoogle Scholar
• Gong J Z, Zheng S, Chiarle R, De Wolf-Peeters C, Palestro G, Frizzera G, et al. Detection of immunoglobulin kappa light chain rearrangements by polymerase chain reaction. An improved method for detecting clonal B-cell lymphoproliferative disorders. Am J Pathol 1999; 155: 355–363
   PubMed Web of Science ®Google Scholar
• Lukowsky A, Marchwat M, Sterry W, Gellrich S. Evaluation of B-cell clonality in archival skin biopsy samples of cutaneous B-cell lymphoma by immunoglobulin heavy chain gene polymerase chain reaction. Leuk Lymphoma 2006; 47: 487–493
   PubMed Web of Science ®Google Scholar
• Pai R K, Chakerian A E, Binder J M, Amin M, Viswanatha D S. B-cell clonality determination using an immunoglobulin kappa light chain polymerase chain reaction method. J Mol Diagn 2005; 7: 300–307
   PubMed Web of Science ®Google Scholar
• Catherwood M A, Alexander H D, McManus D T, Cuthbert R J, Morris T C. Immunoglobulin gene rearrangement investigations in the diagnosis of lymphoid malignancies from formaldehyde-fixed biopsies. Leuk Lymphoma 2003; 44: 645–648
   PubMed Web of Science ®Google Scholar
• Bagg A, Braziel R M, Arber D A, Bijwaard K E, Chu A Y. Immunoglobulin heavy chain gene analysis in lymphomas: a multi-center study demonstrating the heterogeneity of performance of polymerase chain reaction assays. J Mol Diagn 2002; 4: 81–89
   PubMed Web of Science ®Google Scholar
• Hughes J, Weston S, Bennetts B, Prasad M, Angulo R, Jaworskit R, et al. The application of a PCR technique for the detection of immunoglobulin heavy chain gene rearrangements in fresh or paraffin-embedded skin tissue. Pathology 2001; 33: 222–225
   PubMed Web of Science ®Google Scholar
• Ranheim E A, Jones C D, Zehnder J L. Sensitive detection of clonal immunoglobulin rearrangements in frozen and paraffin embedded tissues by polymerase chain reaction heteroduplex analysis. Diagn Mol Pathol 2000; 9: 177–183
   PubMed Web of Science ®Google Scholar
• Signoretti S, Murphy M, Puddu P, DeCoteau J F, Faraggiana T, Kadin M E, et al. Clonality of cutaneous B-cell infiltrates determined by microdissection and immunoglobulin gene rearrangement. Diagn Mol Pathol 1999; 8: 176–182
   PubMed Web of Science ®Google Scholar
• Abdel-Reheim F A, Edwards E, Arber D A. Utility of a rapid polymerase chain reaction panel for the detection of molecular changes in B-cell lymphoma. Arch Pathol Lab Med 1996; 120: 357–363
   PubMed Web of Science ®Google Scholar
• Achille A, Scarpa A, Montresor M, Scardoni M, Zamboni G, Chilosi M, et al. Routine application of polymerase chain reaction in the diagnosis of monoclonality of B-cell lymphoid proliferations. Diagn Mol Pathol 1995; 4: 14–24
   PubMed Web of Science ®Google Scholar
• Diss T C, Pan L, Peng H, Wotherspoon A C, Isaacson P G. Sources of DNA for detecting B cell monoclonality using PCR. J Clin Pathol 1994; 47: 493–496
   PubMed Web of Science ®Google Scholar
• Reed T J, Reid A, Wallberg K, O'Leary T J, Frizzera G. Determination of B-cell clonality in paraffin-embedded lymph nodes using the polymerase chain reaction. Diagn Mol Pathol 1993; 2: 42–49
   PubMed Web of Science ®Google Scholar
• Inghirami G, Szabolcs M J, Yee H T, Corradini P, Cesarman E, Knowles D M. Detection of immunoglobulin gene rearrangement of B cell non-Hodgkin's lymphomas and leukemias in fresh, unfixed and formalin-fixed, paraffin-embedded tissue by polymerase chain reaction. Lab Invest 1993; 68: 746–757
   PubMed Web of Science ®Google Scholar
• van Krieken J H, Langerak A W, Macintyre E A, Kneba M, Hodges E, Sanz R G, et al. Improved reliability of lymphoma diagnostics via PCR-based clonality testing: report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia 2007; 21: 201–206
   PubMed Web of Science ®Google Scholar
• Juul L, Hougs L, Andersen V, Svejgaard A, Barington T. The normally expressed kappa immunoglobulin light chain gene repertoire and somatic mutations studied by single-sided specific polymerase chain reaction (PCR): frequent occurrence of features often assigned to autoimmunity. Clin Exp Immunol 1997; 109: 194–203
   PubMed Web of Science ®Google Scholar
• Stamatopoulos K, Kosmas C, Papadaki T, Pouliou E, Belessi C, Afendaki S, et al. Follicular lymphoma immunoglobulin kappa light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains. Br J Haematol 1997; 96: 132–146
   PubMed Web of Science ®Google Scholar
• van der Burg M, Tumkaya T, Boerma M, de Bruin-Versteeg S, Langerak A W, van Dongen J J. Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at the IGL locus. Blood 2001; 97: 1001–1008
   PubMed Web of Science ®Google Scholar
• Feddersen R M, Martin D J, Van Ness B G. The frequency of multiple recombination events occurring at the human Ig kappa L chain locus. J Immunol 1990; 144: 1088–1093
   PubMed Web of Science ®Google Scholar
• Korsmeyer S J, Hieter P A, Ravetch J V, Poplack D G, Waldmann T A, Leder P. Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci USA 1981; 78: 7096–7100
   PubMed Web of Science ®Google Scholar