Advanced search
Publication Cover
Leukemia & Lymphoma Volume 48, 2007 - Issue 8
Submit an article Journal homepage
63
Views
6
CrossRef citations to date
0
Altmetric
Letter to the Editor

Successful carboxypeptidase G2 rescue of a high-risk elderly Hodgkin lymphoma patient with methotrexate intoxication and renal failure

Michal Sieniawski Department I of Internal Medicine, University of Cologne, Cologne, GermanyCorrespondence[email protected]
,
Matthaeus Rimpler Department of Hematology, Oncology and Tumor-Immunology, University Medical Center Charite, Berlin, Germany
,
Richard Herrmann Division of Oncology, University Hospital, Basel, Switzerland
&
Andreas Josting Department I of Internal Medicine, University of Cologne, Cologne, Germany
Pages 1641-1643 | Received 08 Feb 2007, Accepted 12 May 2007, Published online: 01 Jul 2009

References

  • Josting A DV, Engert A. Methotrexat-pharmakologie. Toxizitaet und rescue-massnahmen bei hochdosierter behandlung. Onkologe 1998; 4: 974–985
  • Bleyer W A. The clinical pharmacology of methotrexate: new applications of an old drug. Cancer 1978; 41: 36–51
  • Ackland S P, Schilsky R L. High-dose methotrexate: a critical reappraisal. J Clin Oncol 1987; 5: 2017–2031
  • Frei E, III, Blum R H, Pitman S W, Kirkwood J M, Henderson I C, Skarin A T, et al. High dose methotrexate with leucovorin rescue. Rationale and spectrum of antitumor activity. Am J Med 1980; 68: 370–376
  • Josting A, Rudolph C, Mapara M, Glossmann J P, Sienawski M, Sieber M, et al. Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma: results of a large multicenter study of the German Hodgkin Lymphoma Study Group (GHSG). Ann Oncol 2005; 16: 116–123
  • Van Den Berg H W, Murphy R F, Kennedy D G. Rapid plasma clearance and reduced rate and extent of urinary elimination of parenterally administered methotrexate as a result of severe vomiting and diarrhoea. Cancer Chemother Pharmacol 1980; 4: 47–48
  • Chabner B A, Young R C. Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues. J Clin Invest 1973; 52: 1804–1811
  • Howell S B, Ensminger W D, Krishan A, Frei E, III. Thymidine rescue of high-dose methotrexate in humans. Cancer Res 1978; 38: 325–330
  • Buchen S, Ngampolo D, Melton R G, Hasan C, Zoubek A, Henze G, et al. Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure. Br J Cancer 2005; 92: 480–487
  • Krause A S, Weihrauch M R, Bode U, Fleischhack G, Elter T, Heuer T, et al. Carboxypeptidase-G2 rescue in cancer patients with delayed methotrexate elimination after high-dose methotrexate therapy. Leuk Lymphoma 2002; 43: 2139–2143

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.