235
Views
8
CrossRef citations to date
0
Altmetric
Original Articles Research

The role of soluble and cell-surface expressed 4-1BB ligand in patients with malignant hemopoietic disorders

, , , , , , & show all
Pages 427-436 | Received 06 Aug 2008, Accepted 21 Dec 2008, Published online: 01 Jul 2009

References

  • Locksley R M, Killeen N, Leonardo M J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001; 104: 487–501
  • Pan P-Y, Gu P, Li Qingsheng, Xu D, Weber K, Chen S-H. Regulation of dendritic cell function by NK cells: mechanisms underlying the synergism in the combination therapy of IL-12 and 4-1BB activation. J Immunol 2004; 172: 4779–4789
  • Laderach D, Wesa A, Galy A. 4-1BB-ligand is regulated on human dendritic cells and induces the production of IL-12. Cell Immunol 2003; 226: 37–44
  • Watts T H. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005; 23: 23–68
  • Goodwin R G, Din W S, Davis-Smith T, Anderson D M, Gimpel S D, Sato T A, et al. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol 1993; 23: 2631
  • Hurtado J C, Kim S H, Pollok K E, Lee Z H, Kwon B S. Potential role of 4-1BB in T cell activation: comparison with the costimulatory molecule CD28. J Immunol 1995; 155: 3360
  • DeBenedette M A, Shahinian A, Mak T W, Watts T H. Costimulation of CD28− T lymphocytes by 4-1BB ligand. J Immunol 1997; 158: 551
  • Chu N R, DeBenedette M A, Stiernholm B JN, Barber B H, Watts T H. Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28-T cells. J Immunol 1997; 158: 3081
  • Melero W, Shuford W, Newby S A, Aruffo A, Ledbetter J A, Hellstrom K E, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 1997; 3: 682
  • Shuford W W, Klussman K, Tritchler D D, Loo D T, Chalupny J, Siadak A W, et al. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 1997; 186: 47
  • Takahashi C, Mittler R S, Vella A T. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J Immunol 1999; 162: 5037
  • Salih H R, Kosowski S G, Haluska V F, Starling G C, Loo D T, Lee F, et al. Constitutive expression of functional 4-1BB (CD137) ligand on carcinoma cells. J Immunol 2000; 165: 2903–2910
  • Michel J, Pauly S, Langstein P, Krammer P H, Schwarz H. CD137 induced apoptosis is independent of CD95. Immunology 1999; 98: 42
  • Palma C, Binaschi M, Bigioni M, Maggi C A, Goso C. CD137 and CD137 ligand constitutively expressed on human T and B leucemia cells signal proliferation and survival. Int J Cancer 2004; 108: 390–398
  • Jung H W, Choi J I, Kwon B S. Serum concentrations of solubile 4-1BB ligand correlated with the disease severity in rheumatoid arthritis. Exp Mol Med 2004; 29;36: 13–22
  • Salih H R, Schmetzer H M, Burke C, Starling G C, Dunn R, Pelka-Fleischer R, et al. Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies. J Immunol 2001; 167: 4059–4066
  • Molica S, Vitelli G, Levato D, Crispino G, Dell'Olio M, Dattilo A, et al. CD27 in B-cell chronic lymphocytic leukemia. Cellular expression, serum release and correlation with other soluble molecules belonging to nerve growth factor receptors (NGFr) superfamily. Haematologica 1998; 83: 398–402
  • Bennett J M, Catovsky D, Daniel M T, Flandrin G, Galton D A, Gralnick H R, et al. Proposals for the classification of the acute leukemias. French-American-British (FAB) co-operative group. Br J Haematol 1976; 33: 451–458
  • Bennett J M, Catovsky D, Daniel M T, Flandrin G, Galton D A, Gralnick H R, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982; 51: 189–199
  • Salih H R, Nuessler V, Claudio D, Starling G C, Peter A. Serum levels of CD137 ligand and CD178 are prognostic factors for progression of myelodysplastic syndrome. Leuk Lymphoma 2004; 45: 301–308
  • Schmetzer H M, Kremser A, Loibl J, Kroell T, Kolb H J. Quantification of ex vivo generated dendritic cells (DC) and leukemia-derived DC contributes to estimate the quality of DC, to detect optimal DC-generating methods or to optimize DC-mediated T-cell-activation-procedures ex vivo or in vivo. Leukemia 2007; 21: 1338–1341
  • Lee A W, Truong T, Bickham K, Fonteneau J-F, Larsson M, Da Silva I, et al. A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: implications for immunotherapy. Vaccine 2002; 20: A8–A22
  • Westers T M, Stam A GM, Scheper R J, Regelink J C, Nieuwint A W, Schuurhuis G J, Loosdrecht A A, et al. Rapid generation of antigen-presenting cells from leukemic blasts in acute myeloid leukemia. Cancer Immunol Immunother 2003; 52: 17–27
  • Houtenbos I, Westers T M, Stam A G, de Gruijl T D, Scheper R J, Ossenkoppele G J, Loosdrecht A A, et al. Serum-free generation of antigen presenting cells from acute myeloid leukemic blasts for active specific immunisation. Cancer Immunol Immunother 2003; 52: 455–462
  • Schuler G, Schuler-Thurner B, Steinman R M. The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 2003; 15: 138–147
  • Kufner S, Pelka Fleischer R, Kroell T, Schmid C, Zitzelsberger H, Salih H, et al. Serum-free generation and quantification of functionally active Leukemia-derived DC is possible from malignant blasts in acute myeloid leukemia and myelodysplastic syndromes. Cancer Immunol Immunother 2005; 54: 953–970
  • Kremser A, Loibl J, Scholl N, Schmid C, Kufner S, Schweiger C, et al. Dendritic cells generated from leukemic blasts an evaluation of different methods. submitted 2009
  • Loibl J, Kremser A, Schmid C, Zitzelsberger H, Buhmann R, Kroell T, et al. Surface marker expression profiles have to be evaluated before and after the generation of dendritic cells (DC) from blasts in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) to characterize and quantify DC in experimental settings. submitted 2009
  • Sato M, Takayama T, Tanaka H, Konishi J, Suzuki T, Kaiga T, et al. Generation of mature dendritic cells fully capable of T helper type 1 polarization using OK-432 combined with prostaglandin E(2). Cancer Sci 2003; 94: 1091–1098
  • Hentschel N, Krusch M, Kiener P A, Kolb H J, Salih H R, Schmetzer H M. Serum levels of sCD137 (4-1BB) ligand are prognostic factors for progression in acute myeloid leukemia but not in non-Hodgkin's lymphoma. Eur J Haematol 2006; 77: 91–101
  • Armitage R J, Fanslow W C, Strockbine L, Sato T A, Clifford K N, Macduff B M, et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992; 357: 80
  • Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993; 75: 1169
  • Alderson M R, Smith C A, Tough T W, Davis-Smith T, Armitage R J, Falk B, et al. Molecular and biological characterization of human 4-1BB and its ligand. Eur J Immunol 1994; 24: 2219
  • Saoulli K, Lee S Y, Cannons J L, Yeh W C, Santana A, Goldstein M D, et al. CD28-independent, TRAF2-dependent costimualtion of resting T cells by -1BB ligand. J Exp Med 1998; 187: 1849
  • Walker P R, Saas P, Dietrich P-Y. Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back. J Immunol 1997; 158: 4521
  • Lee P-K, Chang C-J, Lin C-M. Lipopolysaccharide preferentially induces 4-1BB ligand expression on human monocyte-derived dendritic cells. Immunol Lett 2003; 90: 215–221
  • Salih H R, Starling G C, Knauff M, Davis P M, Pitts W J, Aruffo A, et al. Retinoic acid and vitamin E modulate expression and release of CD178 in carcinoma cells: consequences for instructions of apoptosis in CD95 sensitive cells. Exp Cell Res 2001; 270: 248–258
  • Lickliter J D, Kratzke A, Nguyen P L, Niehans G A, Miller J S. Fas ligand is highly expressed in acute leukemia and during the transformation of chronic myeloid leukemia to blast crisis. Exp Hematol 1999; 27: 1519–1527
  • Lee S W, Park Y, So T, Kwon B S, Cheroutre H, Mittler R S, et al. Identification of regulatory functions for 4-1BBL and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol 2008; 9: 917–926

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.