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Commentary

Stem-cell dose for allogeneic hematopoietic stem cell transplantation in hematological malignancies: is more better?

, MD &
Pages 1395-1396 | Published online: 15 Sep 2009

References

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  • Mohty M, Bilger K, Jourdan E, et al. Higher doses of CD34+peripheral blood stem cells are associated with increased mortality from chronic graft-versus-host disease after allogeneic HLA-identical sibling transplantation. Leukemia 2003; 17: 869–875
  • Champlin R, Khouri I, Shimoni A, et al. Harnessing graft-versus-malignancy: non-myeloablative preparative regimens for allogeneic haematopoietic transplantation, an evolving strategy for adoptive immunotherapy. Br J Haematol 2000; 111: 18–29
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  • Gorin N C, Labopin M, Boiron J M, et al. Results of genoidentical hemopoietic stem cell transplantation with reduced intensity conditioning for acute myelocytic leukemia: higher doses of stem cells infused benefit patients receiving transplants in second remission or beyond – the Acute Leukemia Working Party of the European Cooperative Group for Blood and Marrow Transplantation. J Clin Oncol 2006; 24: 3959–3966
  • Mehta J, Frankfurt O, Altman J, et al. Optimizing the CD34+cell dose for reduced-intensity allogeneic hematopoietic stem cell transplantation. Leuk Lymphoma 2009; 50: 1434–1441

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