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Leukemia & Lymphoma Volume 58, 2017 - Issue 12
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Letters to the Editor

Long-term persistent donor–recipient mixed chimerism without disease recurrence after myeloablative single-unit cord blood transplantation in adult acute myeloid leukemia following myelodysplastic syndrome

Susumu TanoueDepartment of Hematology/Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; View further author information
,
Takaaki KonumaDepartment of Hematology/Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; Correspondence[email protected]
View further author information
,
Satoshi TakahashiDepartment of Hematology/Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; View further author information
,
Eri WatanabeDepartment of IMSUT Clinical Flow Cytometry Laboratory, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; View further author information
,
Natsuko SatoDepartment of IMSUT Clinical Flow Cytometry Laboratory, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; View further author information
,
Nobukazu WatanabeDivision of Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; View further author information
,
Masamichi IsobeDepartment of Hematology/Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; View further author information
,
Seiko KatoDepartment of Hematology/Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; View further author information
,
Jun OoiDepartment of Hematology/Oncology, Teikyo University School of Medicine, Tokyo, JapanView further author information
&
Arinobu TojoDepartment of Hematology/Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; View further author information
 show all
Pages 2973-2975 | Received 04 Mar 2017, Accepted 05 Apr 2017, Published online: 16 May 2017

References

  • Liesveld JL, Rothberg PG. Mixed chimerism in SCT: conflict or peaceful coexistence? Bone Marrow Transplant. 2008;42:297–310.
  • Konuma T, Kato S, Ooi J, et al. Single-unit cord blood transplantation after granulocyte colony-stimulating factor-combined myeloablative conditioning for myeloid malignancies not in remission. Biol Blood Marrow Transplant. 2014;20:396–401.
  • Watanabe N, Takahashi S, Ishige M, et al. Recipient-derived cells after cord blood transplantation: dynamics elucidated by multicolor FACS, reflecting graft failure and relapse. Biol Blood Marrow Transplant. 2008;14:693–701.
  • Lee HC, Saliba RM, Rondon G, et al. Mixed T lymphocyte chimerism after allogeneic hematopoietic transplantation is predictive for relapse of acute myeloid leukemia and myelodysplastic syndromes. Biol Blood Marrow Transplant. 2015;21:1948–1954.
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  • Konuma T, Kato S, Oiwa-Monna M, et al. Early phase mixed chimerism in bone marrow does not affect long-term outcomes of myeloablative single-unit cord blood transplantation for adult patients with hematological malignancies. Leuk Lymphoma. 2016;57:2848–2854.
  • Balon J, Hałaburda K, Bieniaszewska M, et al. Early complete donor hematopoietic chimerism in peripheral blood indicates the risk of extensive graft-versus-host disease. Bone Marrow Transplant. 2005;35:1083–1088.
  • Avery S, Shi W, Lubin M, et al. Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts. Blood. 2011;117:3277–3285.
  • Yokohata E, Kuwatsuka Y, Ohashi H, et al. Impact of T-cell chimerism on relapse after cord blood transplantation for hematological malignancies: Nagoya Blood and Marrow Transplantation Group study. Bone Marrow Transplant. 2017;52:612–614.
  • Woll PS, Kjällquist U, Chowdhury O, et al. Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo. Cancer Cell. 2014;25:794–808.

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