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Leukemia & Lymphoma Volume 60, 2019 - Issue 5
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Letter to the Editor

HBV reactivation in CLL patients with occult HBV infection treated with ibrutinib without viral prophylaxis

Idanna InnocentiInstitute of Hematology, Università Cattolica del Sacro Cuore, Roma, Italy;
,
Francesca MorelliInstitute of Hematology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; ;Institute of Internal Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy;
,
Francesco AutoreInstitute of Hematology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; ;Institute of Internal Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy;
,
Andrea CorbingiInstitute of Hematology, Università Cattolica del Sacro Cuore, Roma, Italy;
,
Raffaella PasqualeFondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico, Institute of Hematology, Milano, Italy;
,
Federica SoràInstitute of Hematology, Università Cattolica del Sacro Cuore, Roma, Italy;
,
Maurizio PompiliInstitute of Internal Medicine, Università Cattolica del Sacro Cuore, Roma, Italy
&
Luca LaurentiInstitute of Hematology, Università Cattolica del Sacro Cuore, Roma, Italy; Correspondence[email protected]
 show all
Pages 1340-1342 | Received 09 Jul 2018, Accepted 08 Sep 2018, Published online: 07 Feb 2019

References

  • Laurenti L, Autore F, Innocenti I, et al. Prevalence, characteristics and management of occult hepatitis B virus infection in patients with chronic lymphocytic leukemia: a single center experience. Leuk Lymphoma. 2015;56:2841–2846.
  • Mallet V, van Bömmel F, Doerig C, et al. Management of viral hepatitis in patients with hematological malignancy and in patients undergoing hemopoietin stem cell transplantation: recommendations of the 5th European Conference on Infections in Leukaemia (ECIL-5). Lancet Infect Dis. 2016;16:606–617.
  • Tedeschi A, Frustaci AM, Mazzucchelli M, et al. Is HBV prophylaxis required during CLL treatment with Ibrutinib? Leuk Lymphoma. 2017;58:2966–2968.
  • Molica S, Levato L, Mirabelli R, et al. Feasibility and safety of therapy with ibrutinib after antiviral control of hepatitis B virus (HBV) reactivation in chronic lymphocytic leukemia patients. Leuk Lymphoma. 2018. [3 p.]. Doi:10.1080/10428194.2018.1436175.
  • Chang CS, Tsai CY, Yan SL. Hepatitis B reactivation in patients receiving targeted therapies. Hematology. 2017;22:592–598.
  • Sun C, Tian X, Lee YS, et al. Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib. Blood. 2015;126:2213–2219.
  • de Jésus Ngoma P, Kabamba B, Dahlqvist G, et al. Occult HBV reactivation induced by ibrutinib treatment: a case report. Acta Gastroenterol Belg. 2015;78:424.
  • Herishanu Y, Katchman H, Polliack A. Severe hepatitis B virus reactivation related to ibrutinib monotherapy. Ann Hematol. 2017;96:689–669.
  • Hammond SP, Chen K, Pandit A, et al. Risk of hepatitis B virus reactivation in patients treated with ibrutinib. Blood J. 2018;131:1987–1990.
  • Kayaaslan B, Guner R. Adverse effects of oral antiviral therapy in chronic hepatitis B. World J Hepatol. 2017;9:227–241.

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