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Leukemia & Lymphoma Volume 60, 2019 - Issue 5
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Letter to the Editor

CD4+/CD8+ immunophenotype switching as a marker for intraocular and CNS involvement in mycosis fungoides

Muhammad HusnainDepartment of Medicine, Division of Hematology, Miller School of Medicine, University of Miami, Miami, FL, USA;
,
Nicholas MackridesDepartment of Pathology and Laboratory Medicine, Division of Hematopathology, Miller School of Medicine, Sylvester Comprehensive Cancer Center University of Miami, Miami, FL, USA;
,
Francisco VegaDepartment of Pathology and Laboratory Medicine, Division of Hematopathology, Miller School of Medicine, Sylvester Comprehensive Cancer Center University of Miami, Miami, FL, USA;
,
Manuel Paez-EscamillaMiller School of Medicine, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA;
,
Arnold M. MarkoeDepartment of Radiation Oncology, Miller School of Medicine, University of Miami, Miami, FL, USA;
,
J. William HarbourMiller School of Medicine, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA;
&
Izidore S. LossosDepartment of Medicine, Division of Hematology, Miller School of Medicine, University of Miami, Miami, FL, USA; ;Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USA; ;Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USACorrespondence[email protected]
 show all
Pages 1308-1311 | Received 21 Jun 2018, Accepted 14 Sep 2018, Published online: 14 Nov 2018

References

  • Benner MF, Jansen PM, Vermeer MH, et al. Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases. Blood. 2012;119:1643–1649.
  • Yang Y, Wickless H. Thinking about CNS metastasis in cutaneous lymphoma: analysis of existing data. Leuk Res Rep. 2017;8:14–18.
  • Epstein EH, Jr., Levin DL, Croft JD, Jr, et al. Mycosis fungoides. Survival, prognostic features, response to therapy, and autopsy findings. Medicine (Baltimore). 1972;51:61–72.
  • Gärtner J. Mycosis fungoides mit Beteiligung der Aderhaut. Klin Monatsbl Augenheilkd. 1957;131:61–69.
  • Foerster HC. Mycosis fungoides with intraocular involvement. Trans Am Acad Ophthalmol Otolaryngol. 1960;64:308–313.
  • Keltner JL, Fritsch E, Cykiert RC, et al. Mycosis fungoides. Arch Ophthalmol. 1977;95:645–650.
  • Erny BC, Egbert PR, Peat IM, et al. Intraocular involvement with subretinal pigment epithelium infiltrates by mycosis fungoides. Br J Ophthalmol.1991;75:698–701.
  • Leitch RJ, Rennie IG, Parsons MA. Ocular involvement in mycosis fungoides. Br J Ophthalmol. 1993;77:126–127.
  • Williams GC, Holz E, Lee AG, et al. T-cell lymphoproliferative disorder of vitreous associated with mycosis fungoides. Arch Ophthalmol. 2000;118:278–280.
  • Lois N, Hiscott PS, Nash J, et al. Immunophenotypic shift in a case of mycosis fungoides with vitreous invasion. Arch Ophthalmol. 2000;118:1692–1694.
  • Ralli M, Goldman JW, Lee E, et al. Intraocular involvement of mycosis fungoides. Arch Ophthalmol. 2009;127:343–345.
  • Reddy R, Kim SJ. Intraocular T-cell lymphoma due to mycosis fungoides and response to intravitreal methotrexate. Ocul Immunol Inflamm. 2011;19:234–236.
  • Jusufbegovic D, Char DH. Clinical variability of ocular involvement in mycosis fungoides. JAMA Ophthalmol. 2015;133:341–343.
  • Braue JA, Daniels AB, Zwerner JP, et al. Intraocular involvement of mycosis fungoides associated with immunophenotypic switch from CD4+ to CD8(+). Blood. 2018;131:932–935.
  • DeAngelis LM, Seiferheld W, Schold SC, et al. Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: radiation therapy oncology group study 93–10. JCO. 2002;20:4643–4648.
  • Humme D, Lukowsky A, Gierisch M, et al. T-cell receptor gene rearrangement analysis of sequential biopsies in cutaneous T-cell lymphomas with the Biomed-2 PCR reveals transient T-cell clones in addition to the tumor clone. Exp Dermatol. 2014;23:504–508.
  • Vega F, Luthra R, Medeiros LJ, et al. Clonal heterogeneity in mycosis fungoides and its relationship to clinical course. Blood. 2002;100:3369–3373.
  • Ponti R, Fierro MT, Quaglino P, et al. TCRgamma-chain gene rearrangement by PCR-based GeneScan: diagnostic accuracy improvement and clonal heterogeneity analysis in multiple cutaneous T-cell lymphoma samples. J Invest Dermatol. 2008;128:1030–1038.
  • Aung PP, Climent F, Muzzafar T, et al. Immunophenotypic shift of CD4 and CD8 antigen expression in primary cutaneous T-cell lymphomas: a clinicopathologic study of three cases. J Cutan Pathol. 2014;41:51–57.
  • Endo C, Naka Y, Miyagaki T, et al. Immunophenotypic shift from CD4(+) to CD8(+) in mycosis fungoides. Br J Dermatol. 2016;175:830–833.
  • Okada S, Nannya Y, Ota S, et al. Cutaneous T-cell lymphoma (mycosis fungoides) relapsed with different immunological phenotype after bone marrow transplant. Br J Dermatol. 2010;162:229–230.
  • Vermeer MH, Geelen FA, Kummer JA, et al. Expression of cytotoxic proteins by neoplastic T cells in mycosis fungoides increases with progression from plaque stage to tumor stage disease. Am J Pathol. 1999;154:1203–1210.

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