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Leukemia & Lymphoma Volume 60, 2019 - Issue 5
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Letter to the Editor

Coexpression of ETV6/MDS1/EVI1 and ETV6/EVI1 fusion transcripts in acute myeloid leukemia with t(3;12)(q26.2;p13) and thrombocytosis

Katsuya YamamotoDivision of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan; Correspondence[email protected]
,
Kimikazu YakushijinDivision of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan;
,
Hiroya IchikawaDivision of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan;
,
Atsuo OkamuraDivision of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan;
,
Shigeki NagaoDivision of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan;
,
Seiji KakiuchiDivision of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan;
,
Keiji KurataDivision of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan;
,
Shinichiro KawamotoDivision of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan;
,
Keiji MatsuiDepartment of Clinical Laboratory, Kobe University Hospital, Kobe, Japan
,
Yuji NakamachiDepartment of Clinical Laboratory, Kobe University Hospital, Kobe, Japan
,
Jun SaegusaDepartment of Clinical Laboratory, Kobe University Hospital, Kobe, Japan
,
Hiroshi MatsuokaDepartment of Clinical Laboratory, Kobe University Hospital, Kobe, Japan
&
Hironobu MinamiDepartment of Clinical Laboratory, Kobe University Hospital, Kobe, Japan
 show all
Pages 1294-1298 | Received 07 Jul 2018, Accepted 22 Sep 2018, Published online: 11 Dec 2018

References

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  • Wieser R. MECOM (Ecotropic Viral Integration Site 1 (EVI1) and Myelodysplastic Syndrome 1 (MDS1-EVI1)). Atlas Genet Cytogenet Oncol Haematol. [cited 2018 Jun 10] Available from: http://AtlasGeneticsOncology.org/Genes/EVI103q26ID19.html
  • De Braekeleer E, Douet-Guilbert N, De Braekeleer M. t(3;12)(q26;p13) ETV6/MECOM. Atlas Genet Cytogenet Oncol Haematol. 2014;18:950–953.
  • Raynaud SD, Grosgeorge BJ, Rodgers K, et al. Fluorescence in situ hybridization analysis of t(3;12)(q26;p13): a recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes. Blood. 1996;88:682–689.
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  • Peeters P, Wlodarska I, Baens M, et al. Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Cancer Res. 1997;57:564–569.
  • Nishimura Y, Wada H, Mori A, et al. Detection of ETV6/MDS1/Evi-1 chimeric transcripts in a patient with acute myelocytic leukemia and t(3;12)(q26;p13). Int J Hematol. 2000;72:108–109.
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  • Al-Achkar W, Aljapawe A, Liehr T, et al. De novo acute myeloid leukemia subtype-M4 with initial trisomy 8 and later acquired t(3;12)(q26;p13) leading to ETV6/MDS1/EVI1 fusion transcript expression: a case report. Oncol Lett. 2014;7:787–790.
  • Kim YJ, Yang JJ, Han Y, et al. A rare case of ETV6/MECOM rearrangement in therapy-related acute myeloid leukemia with t(3;12) and monosomy 7. Clin Lab. 2017;63:415–418.
  • Iwase S, Furukawa Y, Horiguchi-Yamada J, et al. A novel variant of acute myelomonocytic leukemia carrying t(3;12)(q26;p13) with characteristics of 3q21q26 syndrome. Int J Hematol 1998;67:361–368.
  • Boultwood J, Pellagatti A, McKenzie ANJ, et al. Advances in the 5q- syndrome. Blood. 2010;116:5803–5811.
  • Haferlach C, Bacher U, Schnittger S, et al. ETV6 rearrangements are recurrent in myeloid malignancies and are frequently associated with other genetic events. Genes Chromosom Cancer. 2012;51:328–337.

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