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Original Article: Research

Skewing of the T-cell receptor repertoire in patients receiving rituximab after allogeneic hematopoietic cell transplantation: what lies beneath?

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Pages 1685-1692 | Received 09 Sep 2018, Accepted 27 Oct 2018, Published online: 17 Jan 2019

References

  • Pierpont TM, Limper CB, Richards KL. Past, present, and future of rituximab—the world’s first oncology monoclonal antibody therapy. Front Oncol. 2018;8:163.
  • Lund FE, Randall TD. Effector and regulatory B cells: modulators of CD4+ T cell immunity. Nat Rev Immunol. 2010;10:236–247.
  • Papadaki T, Stamatopoulos K, Kosmas C, et al. Clonal T-large granular lymphocyte proliferations associated with clonal B cell lymphoproliferative disorders: report of eight cases. Leukemia. 2002;16:2167–2169.
  • Papadaki T, Stamatopoulos K, Stavroyianni N, et al. Evidence for T-large granular lymphocyte-mediated neutropenia in Rituximab-treated lymphoma patients: report of two cases. Leuk Res. 2002;26:597–600.
  • Ram R, Ben-Bassat I, Shpilberg O, et al. The late adverse events of rituximab therapy - rare but there! Leuk Lymphoma. 2009;50:1083–1095.
  • Stamatopoulos K, Papadaki T, Pontikoglou C, et al. Lymphocyte subpopulation imbalances, bone marrow hematopoiesis and histopathology in rituximab-treated lymphoma patients with late-onset neutropenia. Leukemia. 2008;22:1446–1449.
  • Rose A, Isenalumhe L, Bergh M, et al. Clonal T-cell large granular lymphocytic disorders manifesting in patients with HIV-1 infection : case series and review of the literature. Mediterr J Hematol Infect Dis. 2018;10(1):6–10.
  • Sokol L, Loughran TP. Large granular lymphocyte leukemia. The Oncologist. 2006;11:263–273.
  • O'Keefe CL, Plasilova M, Wlodarski M, et al. Molecular analysis of TCR clonotypes in LGL: a clonal model for polyclonal responses. J Immunol. 2004;172:1960–1969.
  • Lamy T, Moignet A, Loughran TP. LGL leukemia: from pathogenesis to treatment. Blood. 2017;129:1082–1094.
  • Ghia P, Prato G, Stella S, et al. Age-dependent accumulation of monoclonal CD4 + CD8+ double positive T lymphocytes in the peripheral blood of the elderly. Br J Haematol. 2007;139:780–790.
  • Wack A, Cossarizza A, Heltai S, et al. Age-related modifications of the human alpha-beta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int Immunol. 1998;10:1281–1288.
  • Mohty M, Faucher C, Vey N, et al. Features of large granular lymphocytes (LGL) expansion following allogenic stem cell transplantation: a long-term analysis. Leukemia. 2002;16:2129–2133.
  • Kim D, Al-Dawsari G, Chang H, et al. Large granular lymphocytosis and its impact on long-term clinical outcomes following allo-SCT. Bone Marrow Transplant. 2013;48:1104–1111.
  • Nann-Rütti S, Tzankov A, Cantoni N, et al. Large granular lymphocyte expansion after allogeneic hematopoietic stem cell transplant is associated with a cytomegalovirus reactivation and shows an indolent outcome. Biol Blood Marrow Transplant. 2012;18:1765–1770.
  • Berrie JL, Kmieciak M, Sabo RT, et al. Distinct oligoclonal t cells are associated with graft versus host disease after stem-cell transplantation. Transplantation. 2012;93:949–957.
  • Gill H, Ip AHW, Leung R, et al. Indolent T-cell large granular lymphocyte leukaemia after haematopoietic SCT: a clinicopathologic and molecular analysis. Bone Marrow Transplant. 2012;47:952–956.
  • Papalexandri A, Stalika E, Iskas M, et al. Molecular evidence for repertoire skewing of T large granular lymphocyte proliferation after allogeneic hematopoietic SCT: report of two cases. Bone Marrow Transplant. 2013;48:1260–1261.
  • Seggewiss R, Einsele H, Dc W. Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation : an update review article immune reconstitution after allogeneic transplantation and expanding options for immunomodulation : an update. Blood. 2010;115:3861–3868.
  • Gress RE, Emerson SG, Drobyski WR. Immune reconstitution: how it should work, what's broken, and why it matters. Biol Blood Marrow Transplant. 2010;16:S133–S137.
  • Clark JR, Scott SD, Jack AL, et al. Monitoring of chimerism following allogeneic haematopoietic stem cell transplantation (HSCT): technical recommendations for the use of Short Tandem Repeat (STR) based techniques, on behalf of the United Kingdom National External Quality Assessment Service. Br J Haematol. 2015;168:26–37.
  • van Dongen JJM, Langerak AW, Brüggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 concerted action BMH4-CT98-3936. Leukemia. 2003;17:2257–2317.
  • Vardi A, Agathangelidis A, Stalika E, et al. Antigen selection shapes the T-cell repertoire in chronic lymphocytic leukemia. Clin Cancer Res. 2016;22:167–174.
  • Kanda J, Chiou LW, Szabolcs P, et al. Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012;18:1664–1676.e1.
  • Yew PY, Alachkar H, Yamaguchi R, et al. Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2015;50:1227–1234.
  • Stasi R, Del Poeta G, Stipa E, et al. Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura. Blood. 2007;110:2924–2930.
  • Stalika E, Kanellis G, Papalexandri A, et al. Cytotoxic T cell-mediated gastritis after rituximab treatment for gastric malt lymphoma. Leuk Lymphoma. 2014;55:1–5.
  • Tonelli AR, Lottenberg R, Allan RW, et al. Rituximab-induced hypersensitivity pneumonitis. Respiration. 2009;78:225–229.
  • Burton C, Kaczmarski R, Riaz J-M. Interstitial pneumonitis related to rituximab therapy neutropenia in patients treated with Rituximab. N Engl J Med 2003;2690–2691.
  • Rangarajan H, Yassai M, Subramanian H, et al. Emergence of T cells that recognize nonpolymorphic antigens during graft-versus- host disease. Blood. 2012;119:6354–6364.
  • Chang H, Kamel-Reid S, Hussain N, et al. T-cell large granular lymphocytic leukemia of donor origin occurring after allogeneic bone marrow transplantation for B-cell lymphoproliferative disorders. Am J Clin Pathol. 2005;123:196–199.
  • Lopez JEH, Yabe M, Carballo-Zarate AA, et al. Donor-derived T-cell large granular lymphocytic leukemia in a patient with peripheral T-cell lymphoma. J Natl Compr Canc Netw. 2016;14:939–944.
  • Nakagawa N, Yamazaki H, Aoki G, et al. Late graft rejection in association with T-large granular lymphocyte expansion of recipient origin after human leukocyte antigen-haploidentical stem cell transplantation: a case report. Transplant Proc. 2016;48:3222–3224.
  • Goyal T, Thakral B, Wang SA, et al. T-cell large granular lymphocytic leukemia and coexisting B-cell lymphomas: a study from the bone marrow pathology group. Am J Clin Pathol. 2018;149:164–171.

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