References
- Christ TN, Stock W, Knoebel RW. Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen. J Oncol Pharm Pract. 2018;24:299–308.
- Patel B, Kirkwood AA, Dey A, et al. Pegylated-asparaginase during induction therapy for adult acute lymphoblastic leukaemia: toxicity data from the UKALL14 trial. Leukemia. 2017;31:58–64. PubMed PMID: 27480385; PubMed Central PMCID: PMCPMC5154375.
- Toft N, Birgens H, Abrahamsson J, et al. Toxicity profile and treatment delays in NOPHO ALL2008-comparing adults and children with Philadelphia chromosome-negative acute lymphoblastic leukemia. Eur J Haematol. 2016;96:160–169.
- Alshiekh-Nasany R, Douer DL. Carnitine for treatment of pegasparaginase-induced hepatotoxicity. Acta Haematol. 2016;135:208–210.
- Blackman A, Boutin A, Shimanovsky A, et al. Levocarnitine and vitamin B complex for the treatment of pegaspargase-induced hepatotoxicity: a case report and review of the literature. J Oncol Pharm Pract. 2017:1078155217710714.PubMed PMID: 28523950.
- Schulte RR, Madiwale MV, Flower A, et al. Levocarnitine for asparaginase-induced hepatic injury: a multi-institutional case series and review of the literature. Leuk Lymphoma. 2018:1–9.
- Wieduwilt MJ, Goodman A, Jonas BA, et al. l-carnitine for pegylated-l-asparaginase induced hepatotoxicity. J Clin Oncol. 2017;35:e21626–e21626.
- Al-Nawakil C, Willems L, Mauprivez C, et al. Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors. Leuk Lymphoma. 2014;55:1670–1674.
- Lu G, Karur V, Herrington JD, et al. Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and l-carnitine. Proc (Bayl Univ Med Cent). 2016;29:46–47.
- Bohan TP, Helton E, McDonald I, et al. Effect of L-carnitine treatment for valproate-induced hepatotoxicity. Neurology. 2001;56:1405–1409.
- Hatamkhani S, Khalili H, Karimzadeh I, et al. Carnitine for prevention of antituberculosis drug-induced hepatotoxicity: a randomized, clinical trial. J Gastroenterol Hepatol. 2014;29:997–1004.
- Alachkar H, Fulton N, Sanford B, et al. Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. Pharmacogenomics J. 2017;17:274–279. PubMed PMID: 27019981; PubMed Central PMCID: PMCPMC5089920.
- Liu Y, Fernandez CA, Smith C, et al. Genome-wide study links PNPLA3 variant with elevated hepatic transaminase after acute lymphoblastic leukemia therapy. Clin Pharmacol Ther. 2017;PubMed PMID: 28090653; PubMed Central PMCID: PMCPMC5511775.
- Kaya I, Citil M, Sozmen M, et al. Investigation of protective effect of l-carnitine on l-asparaginase-induced acute pancreatic injury in male Balb/c mice. Dig Dis Sci. 2015;60:1290–1296.
- Hinson A, Newbern D, Linardic CM. Asparaginase-induced hypertriglyceridemia presenting as pseudohyponatremia during leukemia treatment. Case Rep Pediatr. 2014;2014:635740.