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Leukemia & Lymphoma Volume 60, 2019 - Issue 9
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Letters to the Editor

Myeloablative single-unit cord blood transplantation overcomes the negative prognostic impact of FLT3-ITD in adult acute myeloid leukemia

Takaaki KonumaDepartment of Hematology/Oncology, The Institute of Medical Science The University of Tokyo, Tokyo, JapanCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-1953-8463
ORCID Icon,
Seiko KatoDepartment of Hematology/Oncology, The Institute of Medical Science The University of Tokyo, Tokyo, Japan
,
Maki Oiwa-MonnaDepartment of Hematology/Oncology, The Institute of Medical Science The University of Tokyo, Tokyo, Japan
,
Mai MizusawaDepartment of Hematology/Oncology, The Institute of Medical Science The University of Tokyo, Tokyo, Japan
,
Masamichi IsobeDepartment of Hematology/Oncology, The Institute of Medical Science The University of Tokyo, Tokyo, Japan
,
Kazuaki YokoyamaDepartment of Hematology/Oncology, The Institute of Medical Science The University of Tokyo, Tokyo, Japan
,
Satoshi TakahashiDepartment of Hematology/Oncology, The Institute of Medical Science The University of Tokyo, Tokyo, Japan
&
Arinobu TojoDepartment of Hematology/Oncology, The Institute of Medical Science The University of Tokyo, Tokyo, JapanORCID Iconhttp://orcid.org/0000-0001-9016-1948
ORCID Icon show all
Pages 2320-2323 | Received 07 Nov 2018, Accepted 30 Jan 2019, Published online: 18 Feb 2019

References

  • Pratz KW, Levis M. How I treat FLT3-mutated AML. Blood. 2017;129:565–571.
  • Schiller GJ, Tuttle P, Desai P. Allogeneic hematopoietic stem cell transplantation in FLT3-ITD-positive acute myelogenous leukemia: the role for FLT3 tyrosine kinase inhibitors post-transplantation. Biol Blood Marrow Transplant. 2016;22:982–990.
  • Eckfeldt CE, Randall N, Shanley RM, et al. Umbilical cord blood transplantation is a suitable option for consolidation of acute myeloid leukemia with FLT3-ITD. Haematologica. 2016;101:e348–e351.
  • Ustun C, Giannotti F, Zhang MJ, et al. Outcomes of UCB transplantation are comparable in FLT3+ AML: results of CIBMTR, EUROCORD and EBMT collaborative analysis. Leukemia. 2017;31:1408–1414.
  • Konuma T, Kato S, Ooi J, et al. Single-unit cord blood transplantation after granulocyte colony-stimulating factor-combined myeloablative conditioning for myeloid malignancies not in remission. Biol Blood Marrow Transplant. 2014;20:396–401.
  • Konuma T, Kato S, Isobe M, et al. Reduced-toxicity myeloablative conditioning consisting of fludarabine/busulfan/low-dose TBI/G-CSF-combined cytarabine in single cord blood transplantation for elderly patients with non-remission myeloid malignancies. Biol Blood Marrow Transplant. 2018; in press.
  • Kanda Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant. 2013;48:452–458.
  • Konuma T, Ooi J, Uchida N, et al. Granulocyte colony-stimulating factor combined regimen in cord blood transplantation for acute myeloid leukemia: a nationwide retrospective analysis in Japan. Haematologica. 2014;99:e264–e268.
  • Milano F, Gooley T, Wood B, et al. Cord-blood transplantation in patients with minimal residual disease. N Engl J Med. 2016;375:944–953.
  • Eapen M, Rocha V, Sanz G, et al. Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. Lancet Oncol. 2010;11:653–660.
  • Terakura S, Atsuta Y, Tsukada N, et al. Comparison of outcomes of 8/8 and 7/8 allele-matched unrelated bone marrow transplantation and single-unit cord blood transplantation in adults with acute leukemia. Biol Blood Marrow Transplant. 2016;22:330–338.
  • Sanz J, Jaramillo FJ, Planelles D, et al. Impact on outcomes of human leukocyte antigen matching by allele-level typing in adults with acute myeloid leukemia undergoing umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2014;20:106–110.
  • Konuma T, Kato S, Ishii H, et al. HLA-DRB1 mismatch is associated with a decreased relapse in adult acute myeloid leukemia after single-unit myeloablative cord blood transplantation. Ann Hematol. 2015;94:1233–1235.
  • Yabe T, Azuma F, Kashiwase K, et al. HLA-DPB1 mismatch induces a graft-versus-leukemia effect without severe acute GVHD after single-unit umbilical cord blood transplantation. Leukemia. 2018;32:168–175.
  • Xuan L, Wang Y, Huang F, et al. Effect of sorafenib on the outcomes of patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation. Cancer. 2018;124:1954–1963.

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