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Leukemia & Lymphoma Volume 60, 2019 - Issue 13
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Letters to the Editor

Progression of JAK2-mutant polycythemia vera to CALR-mutant myelofibrosis severely impacts on disease phenotype and response to therapy

Morten Orebo HolmströmDepartment of Hematology, Zealand University Hospital, Roskilde, Denmark; ;National Center for Cancer Immune Therapy, Department of Hematology, Herlev University Hospital, Herlev, Denmark; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-3764-8578View further author information
ORCID Icon,
Guy W. NovotnyDepartment of Hematology, Herlev University Hospital, Herlev, Denmark; View further author information
,
Jesper PetersenDepartment of Hematology, Herlev University Hospital, Herlev, Denmark; ORCID Iconhttp://orcid.org/0000-0001-6116-5114View further author information
ORCID Icon,
Mia Aaboe-JørgensenNational Center for Cancer Immune Therapy, Department of Hematology, Herlev University Hospital, Herlev, Denmark; View further author information
,
Hans Carl HasselbalchDepartment of Hematology, Zealand University Hospital, Roskilde, Denmark; ;Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; View further author information
,
Mads H. AndersenNational Center for Cancer Immune Therapy, Department of Hematology, Herlev University Hospital, Herlev, Denmark; ;Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark; ORCID Iconhttp://orcid.org/0000-0002-2914-9605View further author information
ORCID Icon,
Signe Ledou NielsenDepartment of Pathology, Herlev University Hospital, Herlev, Denmark; View further author information
,
Daniel El FassiDepartment of Hematology, Herlev University Hospital, Herlev, Denmark; ;Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; ;Institute for Inflammation Research, Rigshospitalet University Hospital, Copenhagen, DenmarkORCID Iconhttp://orcid.org/0000-0001-8226-1658View further author information
ORCID Icon &
Claudia SchöllkopfDepartment of Hematology, Herlev University Hospital, Herlev, Denmark; ORCID Iconhttp://orcid.org/0000-0003-1465-506XView further author information
ORCID Icon show all
Pages 3296-3299 | Received 03 May 2019, Accepted 14 Jun 2019, Published online: 01 Jul 2019

References

  • Kralovics R, Passamonti F, Buser AAS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352:1779–1790.
  • Klampfl T, Gisslinger H, Harutyunyan AS, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369:2379–2390.
  • Nangalia J, Massie CE, Baxter EJ, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369:2391–2405.
  • Grinfeld J, Nangalia J, Baxter EJ, et al. Classification and personalized prognosis in myeloproliferative neoplasms. N Engl J Med. 2018;379:1416–1430.
  • Tefferi A, Lasho TL, Finke CM, et al. CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons. Leukemia. 2014;28:1472–1477.
  • Mansier O, Luque Paz D, Ianotto JC, et al. Clinical and biological characterization of MPN patients harboring two driver mutations, a French intergroup of myeloproliferative neoplasms (FIM) study. Am J Hematol. 2018;93:E84–E86.
  • Haunstrup LM, Ebbesen LH, Hansen M, et al. Skewed ratio between type 1 and type 2 calreticulin mutations in essential thrombocytosis patients with concomitant Janus kinase 2 V617F mutation. Exp Hematol. 2018;68:62–65.
  • Usseglio F, Beaufils N, Calleja A, et al. Detection of CALR and MPL mutations in low allelic burden JAK2 V617F essential thrombocythemia. J Mol Diagn. 2017;19:92–98.
  • Lundberg P, Karow A, Nienhold R, et al. Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms. Blood. 2014;123:2220–2228.
  • Tashkandi H, Moore EM, Tomlinson B, et al. Co-occurrence of type I CALR and two MPL mutations in patient with primary myelofibrosis. Ann Hematol. 2017;96:1417–1418.
  • Chachoua I, Pecquet C, El-Khoury M, et al. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants. Blood. 2016;127:1325–1335.
  • Lim KH, Chang YC, Chiang YH, et al. Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish. Blood Cancer J. 2016;6:e481.
  • Li J, Prins D, Park HJ, et al. Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage. Blood. 2018;131:649–661.
  • Holmström MO, Riley CH, Svane IM, et al. The CALR exon 9 mutations are shared neoantigens in patients with CALR mutant chronic myeloproliferative neoplasms. Leukemia. 2016;30:2413–2416.
  • Holmström MO, Ahmad SM, Klausen U, et al. High frequencies of circulating memory T cells specific for calreticulin exon 9 mutations in healthy individuals. Blood Cancer J. 2019;9:8.

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