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Leukemia & Lymphoma Volume 62, 2021 - Issue 2
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Letters to the Editor

Double trouble or a silver lining? A case report of two patients with NPM1-mutated donor-derived acute myeloid leukemia (AML)

Joanna Bao Ern Loha Department of Haematology, Alfred Hospital, Melbourne, AustraliaORCID Iconhttps://orcid.org/0000-0001-9253-6635View further author information
ORCID Icon,
Patricia Walkera Department of Haematology, Alfred Hospital, Melbourne, Australia;b Peninsula Private Hospital, Melbourne, Australia;c Department of Haematology, Peninsula Health, Melbourne, AustraliaView further author information
,
Sharon Averyd Department of Haematology, Cairns Base Hospital, Cairns, AustraliaView further author information
,
Sushrut Patila Department of Haematology, Alfred Hospital, Melbourne, Australia;e The Australian Centre for Blood Diseases, Monash University, Melbourne, AustraliaView further author information
,
Andrew Spencera Department of Haematology, Alfred Hospital, Melbourne, Australia;e The Australian Centre for Blood Diseases, Monash University, Melbourne, AustraliaView further author information
,
Andrew Weia Department of Haematology, Alfred Hospital, Melbourne, Australia;e The Australian Centre for Blood Diseases, Monash University, Melbourne, AustraliaView further author information
&
Shaun Fleminga Department of Haematology, Alfred Hospital, Melbourne, Australia;f Department of Haematology, Monash Health, Melbourne, Australia;g Department of Haematology, Northern Health, Melbourne, Australia;h Central Clinical School, Monash University, Melbourne, AustraliaCorrespondence[email protected]
View further author information
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Pages 489-491 | Received 03 Aug 2020, Accepted 26 Sep 2020, Published online: 13 Oct 2020

References

  • Rodríguez-Macías G, Martínez-Laperche C, Gayoso J, et al. Mutation of the NPM1 gene contributes to the development of donor cell-derived acute myeloid leukemia after unrelated cord blood transplantation for acute lymphoblastic leukemia. Hum Pathol. 2013;44(8):1696–1699.
  • Herold S, Kuhn M, Bonin M, et al. Donor cell leukemia: evidence for multiple preleukemic clones and parallel long term clonal evolution in donor and recipient. Leukemia 2017;31:1637–1640.
  • Chonabayashi K, Kondo T, Yamamoto K, et al. Successful use of second cord blood transplantation to achieve long-term remission in cord blood donor cell-derived AML harboring a FLT3-ITD and an NPM1 mutation. Bone Marrow Transplant. 2012;47(9):1252–1253.
  • Hahn CN, Ross DM, Feng J, et al. A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone. Leukemia. 2015;29(10):2101–2104.
  • Engel N, Rovo A, Badoglio M, et al. European experience and risk factor analysis of donor cell-derived leukaemias/MDS following haematopoietic cell transplantation. Leukemia. 2019;33(2):508–517.
  • Kayser S, Döhner K, Rgen Krauter J, et al. The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML. Clin Trial. 2011;117(7):2137–2145.
  • Wiseman DH. Donor cell leukemia: a review. Biol Blood Marrow Transplant. 2011;17(6):771–789.
  • Jacobs JFM, Brons PP, Simons A, et al. Therapy-related, donor-derived AML responding to a second allogeneic BMT. Bone Marrow Transplant. 2007;40(5):499–500.
  • Platzbecker U, Middeke JM, Sockel K, et al. Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2): an open-label, multicentre, phase 2 trial. Lancet Oncol. 2018;19(12):1668–1679.

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