Advanced search
Publication Cover
Leukemia & Lymphoma Volume 62, 2021 - Issue 3
Submit an article Journal homepage
233
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Detection of residual disease in chronic myeloid leukemia utilizing genomic next generation sequencing reveals persistence of differentiated Ph+ B cells but not bone marrow stem/progenitors

Daiki Kariganea Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;b Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan;c Stanford Cancer Institute, Stanford, CA, USAORCID Iconhttps://orcid.org/0000-0002-4017-5193
ORCID Icon,
Hidenori Kasaharaa Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;b Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan;d Department of Pathology, New York University School of Medicine, New York, NY, USAORCID Iconhttps://orcid.org/0000-0002-8349-4362
ORCID Icon,
Kouhei Shiroshitaa Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;b Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
,
Shinya Fujitaa Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;b Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
,
Hiroshi Kobayashia Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
,
Shinpei Tamakia Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
,
Rie Yamazakib Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
,
Kaori Yahagie Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan
,
Yoko Yatabee Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan
,
Naomi Kondohe Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan
,
Tomoko Araie Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan
,
Hisako Katagirie Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan
,
Nobuko Shimizue Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan
,
Masatoshi Sakuraib Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
,
Taku Kikuchib Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
,
Jun Katob Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
,
Takayuki Shimizub Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
,
Taeko Hayakawaf Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
,
Tomonori Yaguchif Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
,
Maiko Matsushitag Faculty of Pharmacy, Division of Clinical Physiology and Therapeutics, Keio University, Tokyo, Japan
,
Hideaki Nakajimab Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan;h Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan
,
Yutaka Kawakamif Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
,
Mitsuru Muratae Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan
,
Takehiko Morib Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
,
Takashi Sasakii Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan
,
Shinichiro Okamotob Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, JapanCorrespondence[email protected]
&
Keiyo Takuboa Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, JapanCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-1736-7592
ORCID Icon show all
Pages 679-687 | Received 27 May 2020, Accepted 06 Oct 2020, Published online: 26 Oct 2020

References

  • Houshmand M, Simonetti G, Circosta P, et al. Chronic myeloid leukemia stem cells. Leukemia. 2019;33(7):1543–1556.
  • Mahon FX, Rea D, Guilhot J, et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 2010;11(11):1029–1035.
  • Holyoake TL, Vetrie D. The chronic myeloid leukemia stem cell: stemming the tide of persistence. Blood. 2017;129(12):1595–1606.
  • Kobayashi CI, Takubo K, Kobayashi H, et al. The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells. Blood. 2014;123(16):2540–2549.
  • Sadovnik I, Hoelbl-Kovacic A, Herrmann H, et al. Identification of CD25 as STAT5-dependent growth regulator of leukemic stem cells in Ph + CML. Clin Cancer Res. 2016;22(8):2051–2061.
  • Sadovnik I, Herrmann H, Eisenwort G, et al. Expression of CD25 on leukemic stem cells in BCR-ABL1+ CML: Potential diagnostic value and functional implications. Exp Hematol. 2017;51:17–24.
  • Osumi K, Fukui T, Kiyoi H, et al. Rapid screening of leukemia fusion transcripts in acute leukemia by real-time PCR. Leuk Lymphoma. 2002;43(12):2291–2299.
  • Ross DM, Branford S, Seymour JF, et al. Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR. Leukemia. 2010;24(10):1719–1724.
  • Izzo B, Gottardi EM, Errichiello S, et al. Monitoring chronic myeloid leukemia: how molecular tools may drive therapeutic approaches. Front Oncol. 2019;9:833.
  • Alikian M, Gale RP, Apperley JF, et al. Molecular techniques for the personalised management of patients with chronic myeloid leukaemia. Biomol Detect Quantif. 2017;11:4–20.
  • Chomel JC, Bonnet ML, Sorel N, et al. Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease. Blood. 2011;118(13):3657–3660.
  • Nakase K, Kita K, Otsuji A, et al. Diagnostic and clinical importance of interleukin-2 receptor alpha chain expression on non-T-cell acute leukaemia cells. Br J Haematol. 1992;80(3):317–326.
  • Liu P, Jiang H, Che M, et al. Abnormal CD25 expression on hematopoietic cells in myelodysplastic syndromes. Leuk Res. 2018;67:12–16.
  • Pagani IS, Dang P, Saunders VA, et al. Lineage of measurable residual disease in patients with chronic myeloid leukemia in treatment-free remission. Leukemia. 2020;34(4):1052–1061.
  • Takahashi N, Miura I, Saitoh K, et al. Lineage involvement of stem cells bearing the philadelphia chromosome in chronic myeloid leukemia in the chronic phase as shown by a combination of fluorescence-activated cell sorting and fluorescence in situ hybridization. Blood. 1998;92(12):4758–4763.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.