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Letters to the Editor

RUNX1 gene alterations characterized by allelic preference in adult acute myeloid leukemia

, , , , , , , , , , , , , , , & ORCID Icon show all
Pages 717-721 | Received 27 Feb 2021, Accepted 07 May 2021, Published online: 24 May 2021

References

  • Antony-Debré I, Duployez N, Bucci M, et al. Somatic mutations associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia. Leukemia. 2016;30(4):999–1002.
  • Brown AL, Arts P, Carmichael CL, et al. RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML. Blood Adv. 2020;4(6):1131–1144.
  • Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391–2405.
  • Coccaro N, Zagaria A, Orsini P, et al. RARA and RARG gene downregulation associated with EZH2 mutation in acute promyelocytic-like morphology leukemia. Hum Pathol. 2018;80:82–86.
  • Desmet FO, Hamroun D, Lalande M, et al. Human splicing finder: an online bioinformatics tool to predict splicing signals. Nucleic Acids Res. 2009;37:e67.
  • Leman R, Gaildrat P, Gac GL, et al. Novel diagnostic tool for prediction of variant spliceogenicity derived from a set of 395 combined in silico/in vitro studies: an international collaborative effort. Nucleic Acids Res. 2018;46(15):7913–7923.
  • Chin DWL, Sakurai M, Nah GSS, et al. RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity. Blood Cancer J. 2016;6:379.
  • Luo MC, Zhou SY, Feng DY, et al. Runt-related transcription factor 1 (RUNX1) binds to p50 in macrophages and enhances TLR4-triggered inflammation and septic shock. J Biol Chem. 2016;291(42):22011–22020.
  • Nakagawa M, Shimabe M, Watanabe-Okochi N, et al. AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors. Blood. 2011;118(25):6626–6637.
  • Spender LC, Whiteman HJ, Karstegl CE, et al. Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells. Oncogene. 2005;24(11):1873–1881.
  • McDaniel MM, Kottyan LC, Singh H, et al. Suppression of inflammasome activation by IRF8 and IRF4 in cDCs is critical for T cell priming. Cell Rep. 2020;31:107604.
  • Achuthan A, Cook AD, Lee MC, et al. Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. J Clin Invest. 2016;126(9):3453–3466.
  • Klco JM, Mullighan CG. Advances in germline predisposition to acute leukaemias and myeloid neoplasms. Nat Rev Cancer. 2020;21:122–137.
  • Carraway HE, LaFramboise T. Myeloid neoplasms with germline predisposition: practical considerations and complications in the search for new susceptibility loci. Best Pract Res Clin Haematol. 2020;33(3):101191.
  • Wang CQ, Krishnan V, Tay LS, et al. Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects. Cell Rep. 2014;8(3):767–782.

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