Advanced search
Publication Cover
Leukemia & Lymphoma Volume 62, 2021 - Issue 13
Submit an article Journal homepage
207
Views
1
CrossRef citations to date
0
Altmetric
Letters to the Editor

TAp63 and BCL2 expression are co-affected by cell-extrinsic signals in chronic lymphocytic leukemia

Maria Koutroumania Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, GreeceView further author information
,
Stamatia Laidoua Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, GreeceView further author information
,
Konstantia Kottaa Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, GreeceView further author information
&
Kostas Stamatopoulosa Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece;b Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, SwedenCorrespondence[email protected]
View further author information
Pages 3288-3291 | Received 22 Feb 2021, Accepted 08 Jul 2021, Published online: 29 Jul 2021

References

  • Bergholz J, Xiao ZX. Role of p63 in development, tumorigenesis and cancer progression. Cancer Microenviron. 2012;5(3):311–322.
  • Di Como CJ, Urist MJ, Babayan I, et al. p63 expression profiles in human normal and tumor tissues. Clin Cancer Res. 2002;8(2):494–501.
  • Papakonstantinou N, Ntoufa S, Tsagiopoulou M, et al. Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia. Int J Cancer. 2019;144(11):2695–2706. [Internet]. [cited 2021 Jan 9]. Available from: https://onlinelibrary.wiley.com/doi/abs/https://doi.org/10.1002/ijc.31999.
  • Banjara S, Suraweera CD, Hinds MG, et al. The Bcl-2 family: Ancient origins, conserved structures, and divergent mechanisms. Biomolecules. 2020;10(1):128. [Internet]. MDPI AG; [cited 2020 Oct 11]. Available from:/pmc/articles/PMC7022251/?report=abstract.
  • Buggins AGS, Pepper CJ. The role of Bcl-2 family proteins in chronic lymphocytic leukaemia. Leuk Res. 2010;34(7):837–842. [Internet]. [cited 2020 Oct 11]. Available from: https://pubmed.ncbi.nlm.nih.gov/20359747/.
  • Hanada M, Delia D, Aiello A, et al. bcl-2 Gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood. 1993;82(6):1820–1828.
  • Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005;102(39):13944–13949.
  • Burger JA, O’Brien S. Evolution of CLL treatment — from chemoimmunotherapy to targeted and individualized therapy. Nat Rev Clin Oncol. 2018;15(8):510–527. [Internet]. Nature Publishing Group; [cited 2020 Sep 30]. Available from: https://pubmed.ncbi.nlm.nih.gov/29777163/.
  • Ghia P, Chiorazzi N, Stamatopoulos K. Microenvironmental influences in chronic lymphocytic leukaemia: The role of antigen stimulation. J Intern Med. 2008;264(6):549–562.
  • Sutton LA, Rosenquist R. The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia. Semin Cancer Biol. 2015;34:22–35.
  • Ghia P, Strola G, Granziero L, et al. Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+,CD40L + T cells by producing CCL22. Eur J Immunol. 2002;32(5):1403–1413. [Internet]. [cited 2020 Oct 12]. Available from: https://onlinelibrary.wiley.com/doi/full/https://doi.org/10.1002/1521-4141%28200205%2932%3A5%3C1403%3A%3AAID-IMMU1403%3E3.0.CO%3B2-Y.
  • Fonte E, Vilia MG, Reverberi D, et al. Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells. Haematologica. 2017;102(11):1901–1912. [Internet]. [cited 2020 Oct 13]. Available from:/pmc/articles/PMC5664394/?report = abstract.
  • Thijssen R, Slinger E, Weller K, et al. Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors. Haematologica. 2015;100(8):e302–e306. [cited 2020 Oct 10]. Available from: https://pubmed.ncbi.nlm.nih.gov/25957396/.
  • Sharma S, Pavlasova G, Seda V, et al. miR-29 Modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors. Blood. 2021;137(18):2481–2494.
  • Lantner F, Starlets D, Gore Y, et al. CD74 induces TAp63 expression leading to B-cell survival. Blood. 2007;110(13):4303–4311.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.