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Original Articles

Inhibition of pyrimidine biosynthesis by strobilurin derivatives induces differentiation of acute myeloid leukemia cells

, , , , , , , & show all
Pages 1202-1210 | Received 25 Jun 2021, Accepted 08 Nov 2021, Published online: 08 Dec 2021

References

  • Wang ZY, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood. 2008;111(5):2505–2515.
  • Nowak D, Stewart D, Koeffler HP. Differentiation therapy of leukemia: 3 decades of development. Blood. 2009;113(16):3655–3665.
  • Liu X, Gong Y. Isocitrate dehydrogenase inhibitors in acute myeloid leukemia. Biomark Res. 2019;7:22.
  • Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013;340(6132):622–626.
  • Birendra KC, DiNardo CD. Evidence for clinical differentiation and differentiation syndrome in patients with acute myeloid leukemia and IDH1 mutations treated with the targeted mutant IDH1 inhibitor, AG-120. Clin Lymphoma Myeloma Leuk. 2016;16(8):460–465.
  • Evans DR, Guy HI. Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway. J Biol Chem. 2004;279(32):33035–33038.
  • Reis RAG, Calil FA, Feliciano PR, et al. The dihydroorotate dehydrogenases: past and present. Arch Biochem Biophys. 2017;632:175–191.
  • Sykes DB, Kfoury YS, Mercier FE, et al. Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia. Cell. 2016;167(1):171–186.
  • Wu D, Wang W, Chen W, et al. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Haematologica. 2018;103(9):1472–1483.
  • Seet Q, Ooi LAG, Lindmark B, et al. ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia. Haematologica. 2020;105(9):2286–2297.
  • Christian S, Merz C, Evans L, et al. The novel dihydroorotate dehydrogenase (DHODH) inhibitor Bay 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. Leukemia. 2019;33(10):2403–2415.
  • Bartlett DW, Clough JM, Godwin JR, et al. The strobilurin fungicides. Pest Manag Sci. 2002;58(7):649–662.
  • Sauter H, Steglich W, Anke T. Strobilurins: evolution of a new class of active substances. Angew Chem Int Ed. 1999;38(10):1328–1349.
  • Alzeer J, Chollet J, Heinze-Krauss I, et al. Phenyl beta-methoxyacrylates: a new antimalarial pharmacophore. J Med Chem. 2000;43(4):560–568.
  • Chen H, Taylor JL, Abrams SR. Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations. Bioorg Med Chem Lett. 2007;17(7):1979–1983.
  • Li Z, Wang L, Cong Y, et al. Flucrypyrim, a novel uterine relaxant, has antinociceptive and anti-inflammatory effects in vivo. Sci Rep. 2017;7:42040.
  • Yu ZY, Huang R, Xiao H, et al. Fluacrypyrim, a novel STAT3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active STAT3. Int J Cancer. 2010;127(6):1259–1270.
  • Chai B, Wang S, Yu W, et al. Synthesis of novel strobilurin-pyrimidine derivatives and their antiproliferative activity against human cancer cell lines. Bioorg Med Chem Lett. 2013;23(12):3505–3510.
  • Buttitta LA, Edgar BA. Mechanisms controlling cell cycle exit upon terminal differentiation. Curr Opin Cell Biol. 2007;19(6):697–704.
  • Yang M, Xing S, Ou HL, et al. Vibsanol a induces differentiation of acute myeloid leukemia cells via activation of the PKC signaling pathway and induction of ROS. Leuk Lymphoma. 2018;59(10):2414–2422.
  • Yu ZY, Xiao H, Wang LM, et al. Natural product vibsanin a induces differentiation of myeloid leukemia cells through PKC activation. Cancer Res. 2016;76(9):2698–2709.
  • Vu M, Kassouf N, Ofili R, et al. Doxorubicin selectively induces apoptosis through the inhibition of a novel isoform of Bcl-2 in acute myeloid leukaemia MOLM-13 cells with reduced Beclin 1 expression. Int J Oncol. 2020;57(1):113–121.
  • Zhang X, Hu X, Chen R, et al. Perturbations of metabolomic profiling of spleen from rats infected with Clonorchis sinensis determined by LC-MS/MS method. Front Mol Biosci. 2020;7(561641):561641.
  • Khutornenko AA, Roudko VV, Chernyak BV, et al. Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway. Proc Natl Acad Sci USA. 2010;107(29):12828–12833.
  • Gattermann N, Dadak M, Hofhaus G, et al. Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration. Nucleos Nucleot Nucl Acids. 2004;23(8–9):1275–1279.
  • Matkovic K, Brugnoli F, Bertagnolo V, et al. The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells. Leukemia. 2006;20(6):941–951.
  • Lal L, Li Y, Smith J, et al. Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood. 2005;105(4):1669–1677.
  • Muller FL, Liu Y, Van Remmen H. Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem. 2004;279(47):49064–49073.
  • Sun J, Trumpower BL. Superoxide anion generation by the cytochrome bc1 complex. Arch Biochem Biophys. 2003;419(2):198–206.
  • Dembitz V, Tomic B, Kodvanj I, et al. The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion. J Biol Chem. 2019;294(42):15257–15270.
  • Wang S, Huang X, Sun D, et al. Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling. PLoS One. 2012;7(5):e37427.
  • Vosseller K, Wells L, Lane MD, et al. Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci USA. 2002;99(8):5313–5318.

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