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Leukemia & Lymphoma Volume 63, 2022 - Issue 7
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A retrospective study of ultrahigh-risk (Mayo 2004 stage IIIb) AL amyloidosis and identification of predictors related to extremely early death

Ya-juan Gaoa Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Kai-ni Shena Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Hui-lei Miaoa Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Zhuang Tianb Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Jun Fenga Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Lu Zhanga Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-0860-9625View further author information
ORCID Icon,
Xin-xin Caoa Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Dao-bin Zhoua Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
&
Jian Lia Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4549-0694View further author information
ORCID Icon show all
Pages 1758-1761 | Received 23 Nov 2021, Accepted 14 Jan 2022, Published online: 02 Feb 2022

References

  • Gertz MA. Immunoglobulin light chain amyloidosis: 2020 update on diagnosis, prognosis, and treatment. Am J Hematol. 2020;95(7):848–860.
  • Dispenzieri A, Gertz MA, Kyle RA, et al. Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood. 2004;104(6):1881–1887.
  • Wechalekar AD, Schonland SO, Kastritis E, et al. A european collaborative study of treatment outcomes in 346 patients with cardiac stage III AL amyloidosis. Blood. 2013;121(17):3420–3427.
  • Shen KN, Zhang CL, Tian Z, et al. Bortezomib-based chemotherapy reduces early mortality and improves outcomes in patients with ultra-high-risk light-chain amyloidosis: a retrospective case control study. Amyloid. 2019; Jun26(2):66–73.
  • Vaxman I, Kumar SK, Buadi F, et al. Outcomes among newly diagnosed AL amyloidosis patients with a very high NT-proBNP: implications for trial design. Leukemia. 2021;35(12):3604–3607.
  • Manwani R, Foard D, Mahmood S, et al. Rapid hematologic responses improve outcomes in patients with very advanced (stage IIIb) cardiac immunoglobulin light chain amyloidosis. Haematologica. 2018;103(4):e165–E168.
  • Manwani R, Cohen O, Sharpley F, et al. A prospective observational study of 915 patients with systemic AL amyloidosis treated with upfront bortezomib. Blood. 2019;134(25):2271–2280.
  • Shen KN, Feng J, Huang XF, et al. At least partial hematological response after first cycle of treatment predicts organ response and long-term survival for patients with AL amyloidosis receiving bortezomib-based treatment. Ann Hematol. 2017; Dec96(12):2089–2094.
  • Sun W, Sun J, Zou L, et al. The successful diagnosis and typing of systemic amyloidosis using a Microwave-Assisted Filter-Aided fast sample preparation method and LC/MS/MS Analysis. PLoS One. 2015;10(5):e0127180.
  • Shen K, Sun W, Sun J, et al. [Classification of amyloidosis by laser micro-dissection and mass spectrometry based proteomic analysis]. Zhonghua Xue Ye Xue Za Zhi. 2015;36(2):99–102.
  • Milani P, Basset M, Russo F, et al. Patients with light-chain amyloidosis and low free light-chain burden have distinct clinical features and outcome. Blood. 2017;130(5):625–631.

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