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Leukemia & Lymphoma Volume 63, 2022 - Issue 13
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Letters to the Editor

Single and multiple point NRAS mutations in acute myeloid leukemia: a study of 327 well molecularly characterized patients

Anna Durinikovaa Department of Internal Medicine – Hematology and Oncology, University Hospital Brno, Brno, Czech Republic;b Department of Internal Medicine – Hematology and Oncology, Faculty of Medicine, Masaryk University, Brno, Czech RepublicView further author information
,
Adam Foltaa Department of Internal Medicine – Hematology and Oncology, University Hospital Brno, Brno, Czech RepublicORCID Iconhttps://orcid.org/0000-0001-6509-6902View further author information
ORCID Icon,
Filip Pardyc Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech RepublicView further author information
,
Jan Svatona Department of Internal Medicine – Hematology and Oncology, University Hospital Brno, Brno, Czech Republic;c Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech RepublicView further author information
,
Marie Drncovaa Department of Internal Medicine – Hematology and Oncology, University Hospital Brno, Brno, Czech Republic;b Department of Internal Medicine – Hematology and Oncology, Faculty of Medicine, Masaryk University, Brno, Czech RepublicORCID Iconhttps://orcid.org/0000-0002-5246-8372View further author information
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Barbora Weinbergerovaa Department of Internal Medicine – Hematology and Oncology, University Hospital Brno, Brno, Czech Republic;b Department of Internal Medicine – Hematology and Oncology, Faculty of Medicine, Masaryk University, Brno, Czech RepublicORCID Iconhttps://orcid.org/0000-0001-6460-2471View further author information
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Petr Cetkovskyd Institute of Hematology and Blood Transfusion, Prague, Czech RepublicView further author information
,
Zdenek Racild Institute of Hematology and Blood Transfusion, Prague, Czech RepublicORCID Iconhttps://orcid.org/0000-0003-3511-4596View further author information
ORCID Icon,
Pavel Jindrae Department of Hematology and Oncology, University Hospital Pilsen, Pilsen, Czech RepublicView further author information
,
Tomas Szotkowskif Department of Hemato-Oncology, University Hospital Olomouc, Olomouc, Czech RepublicView further author information
,
Pavel Zakg Department of Internal Medicine – Department of Hematology, University Hospital Hradec Kralove, Hradec Kralove, Czech RepublicORCID Iconhttps://orcid.org/0000-0002-8415-7069View further author information
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Jiri Mayera Department of Internal Medicine – Hematology and Oncology, University Hospital Brno, Brno, Czech Republic;b Department of Internal Medicine – Hematology and Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic;c Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech RepublicORCID Iconhttps://orcid.org/0000-0003-0567-9887View further author information
ORCID Icon &
Ivana Jeziskovaa Department of Internal Medicine – Hematology and Oncology, University Hospital Brno, Brno, Czech Republic;b Department of Internal Medicine – Hematology and Oncology, Faculty of Medicine, Masaryk University, Brno, Czech RepublicCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8760-7718View further author information
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Pages 3237-3240 | Received 06 Apr 2022, Accepted 15 Aug 2022, Published online: 01 Sep 2022

References

  • Bacher U, Haferlach T, Schoch C, et al. Implications of NRAS mutations in AML: a study of 2502 patients. Blood. 2006;107(10):3847–3853.
  • Wang S, Wu Z, Li T, et al. Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia. Sci Rep. 2020;10(1):12152.
  • Kadia TM, Kantarjian H, Kornblau S, et al. Clinical and proteomic characterization of acute myeloid leukemia with mutated RAS. Cancer. 2012;118(22):5550–5559.
  • Papaemmanuil E, Gerstung M, Bullinger L, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374(23):2209–2221.
  • Metzeler KH, Herold T, Rothenberg-Thurley M, et al. Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia. Blood. 2016;128(5):686–698.
  • Bowen DT, Frew ME, Hills R, et al. RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years. Blood. 2005;106(6):2113–2119.
  • Schubbert S, Shannon K, Bollag G. Hyperactive ras in developmental disorders and cancer. Nat Rev Cancer. 2007;7(4):295–308.
  • Kubo K, Naoe T, Kiyoi H, et al. Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia. Jpn J Cancer Res. 1993;84(4):379–387.
  • Bashey A, Gill R, Levi S, et al. Mutational activation of the N-ras oncogene assessed in primary clonogenic culture of acute myeloid leukemia (AML): implications for the role of N-ras mutation in AML pathogenesis. Blood. 1992;79(4):981–989.
  • Morita K, Wang F, Jahn K, et al. Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics. Nat Commun. 2020;11(1):5327.
  • Reuter CW, Krauter J, Onono FO, et al. Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia. Ann Hematol. 2014;93(6):977–982.
  • Schnittger A, Dicker F, Kern W, et al. RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis. Blood. 2011;117(8):2348–2357.
  • Paschka P, Du J, Schlenk RF, et al. Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG). Blood. 2013;121(1):170–177.
  • Döhner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an International Expert Panel. Blood. 2017;129(4):424–447.

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