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Original Articles

Neutrophil to lymphocyte ratio (NLR) impact on the progression-free survival and overall survival of multiple myeloma patients treated with high-dose chemotherapy and autologous stem cell transplantation

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Pages 98-106 | Received 09 May 2022, Accepted 03 Oct 2022, Published online: 01 Nov 2022

References

  • Palumbo A, Anderson K. Multiple myeloma. N Engl J Med. 2011;364(11):1046–1060.
  • van de Donk NWCJ, Pawlyn C, Yong KL. Multiple myeloma. Lancet. 2021;397(10272):410–427.
  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249.
  • Robak P, Robak T. Novel drugs for multiple myeloma. In: Atta-ur-Rahman ZK, editors. Topics in anti-cancer research. Vol. 8. Sharjah: Bentham Science Publishers; 2019. p. 1–43.
  • Dimopoulos MA, Moreau P, Terpos E, et al. Multiple myeloma: EHA-ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021;32(3):309–322.
  • Dhakal B, Szabo A, Chhabra S, et al. Autologous transplantation for newly diagnosed multiple myeloma in the era of novel agent induction: a systematic review and meta-analysis. JAMA Oncol. 2018;4(3):343–350.
  • Richardson PG, Jacobus SJ, Weller EA, et al. Triplet therapy, transplantation, and maintenance until progression in myeloma. N Engl J Med. 2022;387(2):132–147.
  • Candido J, Hagemann T. Cancer-Related inflammation. J Clin Immunol. 2013;33(S1):79–84.
  • Kawano Y, Moschetta M, Manier S, et al. Targeting the bone marrow microenvironment in multiple myeloma. Immunol Rev. 2015;263(1):160–172.
  • Pirozzolo G, Gisbertz SS, Castoro C, et al. Neutrophil-to-lymphocyte ratio as prognostic marker in esophageal cancer: a systematic review and meta-analysis. J Thorac Dis. 2019;11(7):3136–3145.
  • Yang JJ, Hu ZG, Shi WX, et al. Prognostic significance of neutrophil to lymphocyte ratio in pancreatic cancer: a meta-analysis. World J Gastroenterol. 2015;21(9):2807–2815.
  • Li MX, Liu XM, Zhang XF, et al. Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis. Int J Cancer. 2014;134(10):2403–2413.
  • Wang X, Zhang G, Jiang X, et al. Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies. Atherosclerosis. 2014;234(1):206–213.
  • Huang Z, Fu Z, Huang W, et al. Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: a meta-analysis. Am J Emerg Med. 2020;38(3):641–647.
  • Huang WJ, Huang G-T, Zhan QM, et al. The neutrophil to lymphocyte ratio as a novel predictor of asthma and its exacerbation: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2020;24(22):11719–11728.
  • Chan AS, Rout A. Use of neutrophil-to-Lymphocyte and platelet-to-Lymphocyte ratios in COVID-19. J Clin Med Res. 2020;12(7):448–453.
  • Wang J, Zhou X, Liu Y, et al. Prognostic significance of neutrophil-to-lymphocyte ratio in diffuse large B-cell lymphoma: a meta-analysis. PLoS One. 2017;12(4):e0176008.
  • Marcheselli R, Bari A, Tadmor T, et al. Neutrophil-lymphocyte ratio at diagnosis is an independent prognostic factor in patients with nodular sclerosis Hodgkin lymphoma: results of a large multicenter study involving 990 patients. Hematol Oncol. 2017;35(4):561–566.
  • Lucijanic M, Cicic D, Stoos-Veic T, et al. Elevated neutrophil-to-Lymphocyte-ratio and platelet-to-Lymphocyte ratio in myelofibrosis: inflammatory biomarkers or representatives of myeloproliferation itself? Anticancer Res. 2018;38(5):3157–3163.
  • Stefaniuk P, Szymczyk A, Podhorecka M. The neutrophil to lymphocyte and lymphocyte to monocyte ratios as new prognostic factors in hematological Malignancies - A narrative review. Cancer Manag Res. 2020;12:2961–2977.
  • Kyle RA, Rajkumar SV. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia. 2009;23(1):3–9.
  • Durie BGM, Harousseau J-L, Miguel JS, et al. International uniform response criteria for multiple myeloma. Leukemia. 2006;20(9):1467–1473.
  • Rajkumar SV. Updated diagnostic criteria and staging system for multiple myeloma. Am Soc Clin Oncol Educ B. 2016;(36):e418–e423.
  • Sonneveld P, Avet-Loiseau H, Lonial S, et al. Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the international myeloma working group. Blood. 2016;127(24):2955–2962.
  • Palumbo A, Avet-Loiseau H, Oliva S, et al. Revised international staging system for multiple myeloma: a report from international myeloma working group. J Clin Oncol. 2015;33(26):2863–2869.
  • Zeng Q, Liu Z, Li Q, et al. Prognostic value of neutrophil to lymphocyte ratio and clinicopathological characteristics for multiple myeloma: a meta-analysis. Medicine (Baltimore). 2018;97(41):e12678.
  • Mu S, Ai L, Fan F, et al. Prognostic role of neutrophil-lymphocyte ratio in multiple myeloma: a dose-response meta-analysis. Onco Targets Ther. 2018;11:499–507.
  • Romano A, Parrinello NL, Consoli ML, et al. Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents. Ann Hematol. 2015;94(11):1875–1883.
  • Szudy-Szczyrek A, Mlak R, Mielnik M, et al. Prognostic value of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in multiple myeloma patients treated with thalidomide-based regimen. Ann Hematol. 2020;99(12):2881–2891.
  • Lee GW, Park SW, Go SI, et al. The derived neutrophil-to-Lymphocyte ratio Is an independent prognostic factor in transplantation ineligible patients with multiple myeloma. Acta Haematol. 2018;140(3):146–156.
  • Solmaz Medeni S, Acar C, Olgun A, et al. Can neutrophil-to-Lymphocyte ratio, monocyte-to-Lymphocyte ratio, and platelet-to-Lymphocyte ratio at day +100 be used as a prognostic marker in multiple myeloma patients with autologous transplantation? Clin Transplant. 2018;32(9):e13359.
  • Altman DG, Royston P. The cost of dichotomising continuous variables. BMJ. 2006;332(7549):1080.1.
  • Austin PC, Brunner LJ. Inflation of the type I error rate when a continuous confounding variable is categorized in logistic regression analyses. Stat Med. 2004;23(7):1159–1178.
  • Cho H, Yoon DH, Lee JB, et al. Comprehensive evaluation of the revised international staging system in multiple myeloma patients treated with novel agents as a primary therapy. Am J Hematol. 2017;92(12):1280–1286.
  • Lu J, Lu J, Liu A, et al. The applicability of the international staging system in Chinese patients with multiple myeloma receiving bortezomib or Thalidomide-based regimens as induction therapy: a multicenter analysis. Biomed Res Int. 2015;2015:856704.
  • González-Calle V, Slack A, Keane N, et al. Evaluation of revised international staging system (R-ISS) for transplant-eligible multiple myeloma patients. Ann Hematol. 2018;97(8):1453–1462.
  • Ozaki S, Handa H, Saitoh T, et al. Evaluation of the revised international staging system (R-ISS) in japanese patients with multiple myeloma. Ann Hematol. 2019;98(7):1703–1711.

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