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Original Articles

A novel method to investigate drug resistance in the chronic lymphocytic leukemia (CLL) microenvironment: Analysis of CLL Cellular Environment and Response (ACCER)

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Pages 822-834 | Received 10 Mar 2022, Accepted 29 Dec 2022, Published online: 19 Feb 2023

References

  • Byrd J. Chronic lymphocytic leukemia. Toronto, ON Canada: Leukemia & Lymphoma Society of Canada; 2019.
  • Cancer Stat Facts: Leukemia – Chronic Lymphocytic Leukemia (CLL). National Cancer Institute, surveillance, epidemiology and end results program; Bethesda MD: National Cancer Institute 2019.
  • Strati P, Ferrajoli A, Lerner S, et al. Fludarabine, cyclophosphamide, and rituximab (FCR) plus GM-CSF as frontline treatment for patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2014;55(4):828–833.
  • Trimarco V, Ave E, Facco M, et al. Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival. Oncotarget. 2015;6(39):42130–42149.
  • Quiroga M, Balakrishnan L, Kurtova A, et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood. 2009;114(5):1029–1037.
  • Deglesne P-A, Chevallier N, Letestu R, et al. Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression. Cancer Res. 2006;66(14):7158–7166.
  • Burger J, Ghia P, Rosenwald A, et al. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009;114(16):3367–3375.
  • Paduano F, Gaudio E, Mensah A, et al. T-cell leukemia/lymphoma 1 (TCL1): an oncogene regulating multiple signaling pathways. Front Oncol. 2018;8:317.
  • Decker S, Zwick A, Saleem S, et al. Optomized xenograft protocol for chronic lymphocytic leukemia results in high engraftment efficiency for all CLL subgroups. Int J Mol Sci. 2019;20:6277.
  • Zhang W, Pelicano H, Zeng J, et al. Effective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms. Mol Med Rep. 2015;12(5):7374–7388.
  • Zhang W, Trachootham D, Liu J, et al. Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. Nat Cell Biol. 2012;14(3):276–286.
  • Ding L, Zhang W, Yang L, et al. Targeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia. Onco Targets Ther. 2018;11:5151–5170.
  • Kurtova A, Balakrishnan K, Chen R, et al. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood. 2009;114(20):4441–4450.
  • Rodenhizer D, Dean T, Xu B, et al. Three-dimensional engineered hetergeneous tumor model for assessing cellular environment and response. Nat Protoc. 2018;13(9):1917–1957.
  • Rodenhizer D, Cojocari D, Wouters B, et al. Development of TRACER: tissue roll for analysis of cellular environment and response. IOP Sci Biofabricat. 2016;8(4):045008.
  • Rodenhizer D, Gaude E, Cojocari D, et al. A three-dimensional engineered tumor for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients. Nat Mater. 2016;15(2):227–234.
  • Young M, Rodenhizer D, Dean T, et al. A TRACER 3D co-culture tumor model for head and neck cancer. Biomaterials. 2018;164:54–69.
  • Derda R, Tang S, Laromaine A, et al. Multizone paper platforms for 3D cell cultures. PLoS One. 2011;6(5):e18940.
  • Sbara F., Pinos R., Barbaglio F., et al 3D bioprinting allows establishment of long-term 3D culture model for chronic lymphocytic leukemia cells. Front. Immunol. 2022;12:639572
  • Derda R, Laromaine A, Mammoto A, et al. Paper-supported 3D cell culture for tissue-based bioassays. Proc Natl Acad Sci U S A. 2009;106(44):18457–18462.
  • Barbaglio F., Belloini D., Scarfo L. et al Three deminional co-culture model of chronic lymphocytic leukemia bone marrow microenvironment predicts patient-specific responses to mobilizing agents. Haematologica 2021;106:2334–2344.

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