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Focus On: Clinical Trial

NO147: A Randomized Phase III Trial of Oxaliplatin Plus 5-Fluorouracil, and Leucovorin (Modified FOLFOX6) with or without Cetuximab after Curative Resection for Patients with Stage III Colon Cancer

Pages 20-21 | Published online: 01 Aug 2017

References

  • Andre T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 2004;350:2343–51.
  • Bler JP, Weiand SH, O'Connell MJ, et al. Neurotoxicity From Oxaliplatin Combined With Weekly Bolus Fluorouracil and Leucovorin As Surgical Adjuvant Chemotherapy for Stage II and III Colon Cancer: NSABP C-07. J Clin Oncol. 2007; 25:2198–2204.
  • Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004;351:337–45.
  • Maughan T., on behalf of the COIN Trial Management Group and Investigators. Cetuximab (C), oxaliplatin (Ox) and fluoropyrimidine (Fp): Toxicity during the first 12 weeks of treatment for the first 804 patients entered into the MRC COIN (CR10) trial. J Clin Oncol. (Meeting Abstracts) 2007;25:181s.
  • Rubio Diaz E, Tabernero J, van Cutsem E, et al. Cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer: An international phase II study. J Clin Oncol. (Meeting Abstracts) 2005;23:254s.
  • Seufferlein T, Dittrich C, Riemann J, et al. A phase I/II study of cetuximab in combination with 5-fluorouracil (5-FU)/folinic acid (FA) plus weekly oxaliplatin (L-OHP) (FUFOX) in the first-line treatment of patients with metastatic colorectal cancer (mCRC) expressing epidermal growth factor receptor (EGFR). Preliminary results. J Clin Oncol. (Meeting Abstracts) 2005;23:281s.

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