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Original Articles

Antiviral Compounds Against Nucleocapsid Protein of Porcine Epidemic Diarrhea Virus

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References

  • Martelli P, Lavazza A, Nigrelli AD, Merialdi G, Alborali LG, Pensaert MB. Epidemic of diarrhoea caused by porcine epidemic diarrhoea virus in Italy. Vet Rec 2008; 162:307–310.
  • Song D, Park B. Porcine epidemic diarrhea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines. Virus Genes 2012; 44:167–175.
  • Xu X, Zhang H, Zhang Q, et al. Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression. Vet Microbiol 2013; 164:212–221.
  • Ducatelle R, Coussement W, Pensaert MB, Debouck P, Hoorens J. In vivo morphogenesis of a new porcine enteric coronavirus, CV 777. Arch Virol 1981; 68:35–44.
  • Pensaert MB, de Bouck P. A new coronavirus-like particle associated with diarrhea in swine. Arch Virol 1978; 58:243–247.
  • Kocherhans R, Bridgen A, Ackermann M, Tobler K. Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence. Virus Genes 2001; 23:137–144.
  • Wang K, Lu W, Chen J, et al. PEDV ORF3 encodes an ion channel protein and regulates virus production. FEBS Lett 2012; 586:384–391.
  • Beall A, Yount B, Lin CM, et al. Characterization of a pathogenic full-length cDNA clone and transmission model for porcine epidemic diarrhea virus strain PC22A. MBio 2016; 7:e01451–15.
  • Lee C, Park CK, Lyoo YS, du Lee S. Genetic differentiation of the nucleocapsid protein of Korean isolates of porcine epidemic diarrhoea virus by RT-PCR based restriction fragment length polymorphism analysis. Vet J 2008; 178:138–140.
  • Li BX, Ge JW, Li YJ. Porcine aminopeptidase N is a functional receptor for the PEDV coronavirus. Virology 2007; 365:166–172.
  • You J, Dove BK, Enjuanes L, et al. Subcellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein. J Gen Virol 2005; 86:3303–3310.
  • You JH, Reed ML, Hiscox JA. Trafficking motifs in the SARS coronavirus nucleocapsid protein. Biochem Biophys Res Commun 2007; 358:1015–1020.
  • Duarte M, Gelfi J, Lambert P, Rasschaert D, Laude H Genome organization of porcine epidemic diarrhoea virus. Adv Expt Med Biol 1993; 342:55–60.
  • Tobler K, Bridgen A, Ackermann M. Sequence analysis of the nucleocapsid protein gene of porcine epidemic diarrhoea virus. Adv Expt Med Biol 1993; 342:49–54.
  • Stohlman SA, Baric RS, Nelson GN, Soe LH, Welter LM, Deans RJ. Specific interaction between coronavirus leader RNA and nucleocapsid protein. J Virol 1988; 62:4288–95.
  • Tang TK, Wu MP, Chen ST, et al. Biochemical and immunological studies of nucleocapsid proteins of severe acute respiratory syndrome and 229E human coronaviruses. Proteomics 2005; 5:925–937.
  • Lin SY, Liu CL, Chang YM, Zhao J, Perlman S, Hou MH. Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target. J Med Chem 2014; 57:2247–2257.
  • Arnold K, Bordoli L, Kopp J, Schwede T. The Swiss-model workspace: a web-based environment for protein structure homology modelling. Bioinformatics 2006; 22:195–201.
  • Zhao S, Xue Y, Hao J, Liang C. The RNA-binding properties and domain of Rice stripe virus nucleocapsid protein. Virus Genes 2015; 51:276–82.
  • Soowannayan C, Cowley JA, Michalski WP, Walker PJ. RNA-binding domain in the nucleocapsid protein of gill-associated nidovirus of penaeid shrimp. Plos One 2011; 6:e22156.
  • Yang JL, Ha TK, Dhodary B, et al. Oleanane triterpenes from the flowers of Camellia japonica inhibit porcine epidemic diarrhea virus (PEDV) replication. J Med Chem 2015; 58:1268–1280.
  • Yook HS, Kim KH, Park JE, Shin HJ. Antioxidative and antiviral properties of flowering cherry fruits (Prunus serrulata L. var spontanea) Am J Chin Med 2010; 38:937–948.
  • Tramontano A, Morea V. Assessment of homology-based predictions in CASP5. Proteins 2003; 53:352–368.
  • De Rienzo F, Fanelli F, Menziani MC, De Benedetti PG. Theoretical investigation of substrate specificity for cytochromes P450 IA2, P450 IID6 and P450 IIIA4. J Comput Aid Mol Des 2000; 14:93–116.
  • Jung JW, An JH, Na KB, Kim YS, Lee W. The active site and substrates binding mode of malonyl-CoA synthetase determined by transferred nuclear Overhauser effect spectroscopy, site-directed mutagenesis, and comparative modeling studies. Protein Sci 2000; 9:1294–1303.
  • Ginalski K, Rychlewski L, Baker D, Grishin NV. Protein structure prediction for the male-specific region of the human Y chromosome. Proc Natl Acad Sci 2004; 101:2305–2310.
  • Talukdar AS, Wilson DL. Modeling and optimization of rotational C-arm stereoscopic X-ray angiography. IEEE Trans Med Imaging 1999; 18:604–616.
  • Zhou Y, Johnson ME. Comparative molecular modeling analysis of-5-amidinoindole and benzamidine binding to thrombin and trypsin: specific H-bond formation contributes to high 5-amidinoindole potency and selectivity for thrombin and factor Xa. J Mol Recognit 1999; 12:235–241.
  • Ceulemans H, Russell RB. Fast fitting of atomic structures to low-resolution electron density maps by surface overlap maximization. J Mol Biol 2004; 338:783–793.
  • Schein CH. Production of soluble recombinant proteins in bacteria. Biotechnology 1989; 7:1141–1148.
  • Hughes JP, Rees S, Kalindjian SB, Philpott KL. Principles of early drug discovery. Br J Pharmacol 2011; 162:1239–49.
  • Lysaa RA, Giverhaug T, Wold HL, Aarbakke J. Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide. Eur J Clin Pharmacol 1996; 49:393–396.
  • Sekiguchi T, Nagamine T. Inhibition of free radical generation by biotin. Biochem Pharmacol 1994; 47:594–596.
  • Roy K, De AU, Sengupta C. Evaluation of glutathione and ascorbic acid as suppressors of drug-induced lipid peroxidation. Indian J Exp Biol 2000; 38:580–586.
  • Pardoe IS. Treatment of DNA viral infections of the eye. WO 2008020243 A1. 2008; https://www.google.com/patents/WO2008020243A1?cl=en
  • Galvao J, Davis B, Tilley M, Normando E, Duchen MR, Cordeiro MF. Unexpected low-dose toxicity of the universal solvent DMSO. FASEB J 2014; 28:1317–1330.

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