The 12-bp indel in the SMAD family member 2 gene is associated with goat growth traits

References

• Xiong Y, Wang Y, Xu Q, et al. LKB1 regulates goat intramuscular adipogenesis through focal adhesion pathway. Front Physiol. 2021;12:755598.
   PubMed Web of Science ®Google Scholar
• Wijayanti D, Erdenee S, Akhatayeva Z, et al. Genetic polymorphisms within the ETAA1 gene associated with growth traits in Chinese sheep breeds. Anim Genet. 2022;53(3):460–465.
   PubMed Web of Science ®Google Scholar
• Tang Q, Zhang X, Wang X, et al. Detection of two insertion/deletions (indels) within the ADAMTS9 gene and their associations with growth traits in goat. Small Rumin Res. 2019;180:9–14.
   Web of Science ®Google Scholar
• Cui W, Liu N, Zhang X, et al. A 20-bp insertion/deletion (indel) polymorphism within the CDC25A gene and its associations with growth traits in goat. Arch Anim Breed. 2019;62(1):353–360.
   PubMed Web of Science ®Google Scholar
• Wang K, Cui Y, Wang Z, et al. One 16 bp insertion/deletion (indel) within the KDM6A gene revealing strong associations with growth traits in goat. Gene. 2019;686:16–20.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang K, Liu J, et al. An 11-bp indel polymorphism within the CSN1S1 gene is associated with milk performance and body measurement traits in Chinese goats. Animals. 2019;9(12):1114.
   Web of Science ®Google Scholar
• Droguett R, Cabello-Verrugio C, Santander C, Brandan E. TGF-β receptors, in a Smad-independent manner, are required for terminal skeletal muscle differentiation. Exp Cell Res. 2010;316(15):2487–2503.
   PubMed Web of Science ®Google Scholar
• Kamato D, Burch ML, Piva TJ, et al. Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation. Cell Signal. 2013;25(10):2017–2024.
   PubMed Web of Science ®Google Scholar
• Weiss A, Attisano L. The TGFbeta superfamily signaling pathway: TGFbeta superfamily signaling pathway. Wiley Interdiscip Rev Dev Biol. 2013;2(1):47–63.
   PubMed Web of Science ®Google Scholar
• Zhu X, Topouzis S, Liang L f, Stotish RL. Myostatin signaling through Smad2, Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism. Cytokine. 2004;26(6):262–272.
   PubMed Web of Science ®Google Scholar
• Miyake T, Aziz A, C. McDermott J. Maintenance of the undifferentiated state in myogenic progenitor cells by TGFβ signaling is SMAD independent and requires MEK activation. IJMS. 2020;21(3):1057.
   Google Scholar
• Rezaei HB, Kamato D, Ansari G, Osman N, Little PJ. Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle: Smad2/3 linker region phosphorylation. Clin Exp Pharmacol Physiol. 2012;39(8):661–667.
   PubMed Web of Science ®Google Scholar
• Gao W, Su R, Sun W, et al. Temporal and spatial expression of Smads and their correlation with YAP1 expression in sheep. Genet Mol Res. 2016;15(3):15037715
   Web of Science ®Google Scholar
• Wang QZ, Su R, Lv XY, et al. Analysis of the spatiotemporal expression of major genes in the TGF-β/Smad signaling pathway and correlation analysis using Hu sheep muscle tissue. Genet Mol Res. 2016;15(2):15028133.
   Web of Science ®Google Scholar
• Yang Z, Song C, Jiang R, et al. Micro-ribonucleic acid-216a regulates bovine primary muscle cells proliferation and differentiation via targeting SMAD nuclear interacting protein-1 and Smad7. Front Genet. 2019;10:1112.
   PubMed Web of Science ®Google Scholar
• Lin E, Kuo PH, Liu YL, Yang AC, Tsai SJ. Transforming growth factor-β signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population. Sci Rep. 2017;7(1):13589.
   PubMedGoogle Scholar
• Wijayanti D, Zhang S, Bai Y, et al. Investigation on mRNA expression and genetic variation within goat SMAD2 gene and its association with litter size. Anim Biotechnol. 2022;18:1–9.
   Google Scholar
• Zhang X, Yan H, Wang K, et al. Goat CTNNB1: mRNA expression profile of alternative splicing in testis and association analysis with litter size. Gene. 2018;679:297–304.
   PubMed Web of Science ®Google Scholar
• Aljanabi SM, Martinez I. Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques. Nucleic Acids Res. 1997;25(22):4692–4693.
   PubMed Web of Science ®Google Scholar
• Wijayanti D, Zhang S, Yang Y, et al. Goat SMAD family member 1 (SMAD1): mRNA expression, genetic variants, and their associations with litter size. Theriogenology. 2022;193:11–19.
   PubMed Web of Science ®Google Scholar
• Li Z, Zhang Z, He Z, et al. A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Res. 2009;19(4):519–523.
   PubMed Web of Science ®Google Scholar
• Serrote CML, Reiniger LRS, Silva KB, Rabaiolli Sm dos S, Stefanel CM. Determining the polymorphism information content of a molecular marker. Gene. 2020;726:144175.
   PubMed Web of Science ®Google Scholar
• Zheng J, Wang Z, Yang H, et al. Pituitary transcriptomic study reveals the differential regulation of lncRNAs and mRNAs related to prolificacy in different FecB genotyping sheep. Genes. 2019;10(2):157.
   PubMed Web of Science ®Google Scholar
• Yang H, Wan Z, Jin Y, Wang F, Zhang Y. SMAD2 regulates testicular development and testosterone synthesis in Hu sheep. Theriogenology. 2021;174:139–148.
   PubMed Web of Science ®Google Scholar
• An X, Cao H, Liu S, Cao B. Effects of TG interaction factor 1 on synthesis of estradiol and progesterone in granulosa cells of goats through SMAD2/3-SP1 signaling pathway. Anim Reprod Sci. 2021;229:106750.
   PubMed Web of Science ®Google Scholar
• Gunia M, Phocas F, Arquet R, Alexandre G, Mandonnet N. Genetic parameters for body weight, reproduction, and parasite resistance traits in the Creole goat. J Anim Sci. 2011;89(11):3443–3451.
   PubMed Web of Science ®Google Scholar
• Yang Q, Yan H, Li J, et al. A novel 14-bp duplicated deletion within goat GHR gene is significantly associated with growth traits and litter size. Anim Genet. 2017;48(4):499–500.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Cui W, Yang H, et al. A novel missense mutation (L280V) within POU1F1 gene strongly affects litter size and growth traits in goat. Theriogenology. 2019;135:198–203.
   PubMed Web of Science ®Google Scholar
• Jiang E, Kang Z, Wang X, et al. Detection of insertions/deletions (InDels) within the goat Runx2 gene and their association with litter size and growth traits. Anim Biotechnol. 2021;32(2):169–177.
   PubMed Web of Science ®Google Scholar
• Saneyasu T, Honda K, Kamisoyama H. Myostatin increases Smad2 phosphorylation and atrogin-1 expression in chick embryonic myotubes. J Poult Sci. 2019;56(3):224–230.
   PubMed Web of Science ®Google Scholar
• Liu C, Yuan B, Chen H, et al. Effects of MiR-375-BMPR2 as a key factor downstream of BMP15/GDF9 on the Smad1/5/8 and Smad2/3 signaling pathways. Cell Physiol Biochem. 2018;46(1):213–225.
   PubMedGoogle Scholar
• Wang Y, Ho CC, Bang E, et al. Bone morphogenetic protein 2 stimulates noncanonical SMAD2/3 signaling via the BMP type 1A receptor in gonadotrope-like cells: implications for FSH synthesis. Endocrinology. 2014;155(5):1970–1981.
   PubMed Web of Science ®Google Scholar
• Wang Y, Guo F, Qu H, Luo C, Wang J, Shu D. Associations between variants of bone morphogenetic protein 7 gene and growth traits in chickens. Br Poult Sci. 2018;59(3):264–269.
   PubMed Web of Science ®Google Scholar
• Singh SP, Kumar R, Kumari P, Kumar S, Mitra A. Characterization of 5′ upstream region and investigation of TTTTA deletion in 5′ UTR of myostatin (MSTN) gene in Indian goat breeds. Anim Biotechnol. 2014;25(1):55–68.
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhang X, Jiang E, et al. InDels within caprine IGF2BP1 intron 2 and the 3′‐untranslated regions are associated with goat growth traits. Anim Genet. 2020;51(1):117–121.
   PubMed Web of Science ®Google Scholar
• Wang S, Yi X, Wu M, et al. Detection of key gene InDels in TGF-β pathway and its relationship with growth traits in four sheep breeds. Anim Biotechnol. 2021;32(2):194–204.
   PubMed Web of Science ®Google Scholar
• Ottaviani S, Stebbing J, Frampton AE, et al. TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Nat Commun. 2018;9(1):1845.
   PubMedGoogle Scholar
• Jacob AG, Smith CWJ. Intron retention as a component of regulated gene expression programs. Hum Genet. 2017;136(9):1043–1057.
   PubMed Web of Science ®Google Scholar
• Mishra SK, Thakran P. Intron specificity in pre-mRNA splicing. Curr Genet. 2018;64(4):777–784.
   PubMed Web of Science ®Google Scholar
• Yang L, Jin G, Zhao X, Zheng Y, Xu Z, Wu W. PIP: a database of potential intron polymorphism markers. Bioinformatics. 2007;23(16):2174–2177.
   PubMed Web of Science ®Google Scholar
• Shaul O. How introns enhance gene expression. Int J Biochem Cell Biol. 2017;91(Pt B):145–155.
   PubMedGoogle Scholar
• Zheng J, Deng T, Jiang E, et al. Genetic variations of bovine PCOS-related DENND1A gene identified in GWAS significantly affect female reproductive traits. Gene. 2021;802:145867.
   PubMed Web of Science ®Google Scholar