Morphological Alteration and Intracellular ROS Generation Confirm Apoptosis Induction on EAC Cells by Leucas Indica Bark Extract

References

• Ekor, M. The Growing Use of Herbal Medicines: issues Relating to Adverse Reactions and Challenges in Monitoring Safety. Front. Neurol 2014, 4, 177.
   Google Scholar
• Kumar Bargah, R. Preliminary Test of Phytochemical Screening of Crude Ethanolic and Aqueous Extract of Moringa Pterygosperma Gaertn. J. Pharmacogn. Phytochem. 2015, 4(1), 07–09 .
   Google Scholar
• Zhang, A.; Sun, H.; Wang, X. Recent Advances in Natural Products from Plants for Treatment of Liver Diseases. Eur. J. Med. Chem 2013, 63, 570–577. DOI: 10.1016/j.ejmech.2012.12.062.
   PubMed Web of Science ®Google Scholar
• Torre, L. A.; Bray, F.; Siegel, R. L.; Ferlay, J.; Lortet-Tieulent, J.; Jemal, A. Global Cancer Statistics, 2012. CA. Cancer J. Clin 2015, 65(2), 87–108. DOI: 10.3322/caac.21262.
   PubMed Web of Science ®Google Scholar
• Jemal, A.; Bray, F.; Center, M. M.; Ferlay, J.; Ward, E.; Forman, D. Global Cancer Statistics. CA. Cancer J. Clin 2011, 61(2), 69–90. DOI: 10.3322/caac.20107.
   PubMed Web of Science ®Google Scholar
• Valko, M.; Rhodes, C. J.; Moncol, J.; Izakovic, M.; Mazur, M. Free Radicals, Metals and Antioxidants in Oxidative Stress-Induced Cancer. Chem.-Biol. Interact 2006, 160(1), 1–40. DOI: 10.1016/j.cbi.2005.12.009.
   PubMed Web of Science ®Google Scholar
• Zehiroglu, C.; Ozturk Sarikaya, S. B. The Importance of Antioxidants and Place in Today’s Scientific and Technological Studies. J. Food Sci. Technol 2019, 56(11), 4757–4774. DOI: 10.1007/s13197-019-03952-x.
   PubMed Web of Science ®Google Scholar
• Nimse, S. B.; Pal, D. Free Radicals, Natural Antioxidants, and Their Reaction Mechanisms. RSC Adv 2015, 5(35), 27986–28006. DOI: 10.1039/C4RA13315C.
   Web of Science ®Google Scholar
• Thyagarajan, A.; Sahu, R. P. Potential Contributions of Antioxidants to Cancer Therapy: immunomodulation and Radiosensitization. Integr. Cancer Ther 2018, 17(2), 210–216. DOI: 10.1177/1534735416681639.
   PubMed Web of Science ®Google Scholar
• Helfinger, V.; Schröder, K. Redox Control in Cancer Development and Progression. Mol Aspects Med 2018, 63, 88–98. DOI: 10.1016/j.mam.2018.02.003.
   PubMed Web of Science ®Google Scholar
• Simon, H. U.; Haj-Yehia, A.; Levi-Schaffer, F. Role of Reactive Oxygen Species (ROS) in Apoptosis Induction. Apoptosis. 2000, 5(5), 415–418. DOI: 10.1023/A:1009616228304.
   PubMed Web of Science ®Google Scholar
• Pelicano, H.; Carney, D.; Huang, P. ROS Stress in Cancer Cells and Therapeutic Implications. Drug Resist. Updates. 2004, 7(2), 97–110. DOI: 10.1016/j.drup.2004.01.004.
   PubMed Web of Science ®Google Scholar
• Joshi, R. K. GC/MS Analysis of the Essential Oil of Leucas Indica from India. Nat. Prod. Commun 2014, 9(11), 1607–1608 doi:10.1177/1934578X1400901119.
   PubMed Web of Science ®Google Scholar
• R, C.; Rao, S. Acute anti-inflammatory Activity of Ethanolic Extract of Leaves of Leucas Indica by Carrageenan Induced Paw Oedema in Wistar Albino Rats. Int. J. Basic Clin. Pharmacol. 2013, 2(3), 302. DOI: 10.5455/2319-2003.ijbcp20130613.
   Google Scholar
• Rahmatullah, M.; Rahman, L.; Rehana, F.; Kalpana, M. A., and Khatun, M. A. A Scientific Evaluation of Medicinal Plants Used in the Folk Medicinal System of Five Villages in Narsinghdi District, Bangladesh. Am. J. Sustain. Agric. 2010, 4(1), 55–64 .
   Google Scholar
• Babu, N.; Singh, A.; Singh, R. Therapeutics Potential and Pharmacological Properties of Leucas Indica : a Review. Pharma Innov. J. 2018, 7, 564–568.
   Google Scholar
• Roghini, R., and Vijayalakshmi, K. Phytochemical Screening, Quantitative Analysis of Flavonoids And minerals in Ethanolic Extract of Citrus Paradisi. Int. J. Pharm. Sci. Res. 2018, 9, 4859–4864 doi:10.13040/IJPSR.0975-8232.9(11).4859-64.
   Web of Science ®Google Scholar
• Sawant, R.; Godghate, A. Qualitative Phytochemical Screening of Rhizomes of Curcuma Longa Linn. Int J Sci, Env. 2015, 2, 634–641.
   Google Scholar
• Meyer, B. N.; Ferrigni, N. A.; Putnam, J. E.; Jacobsen, L. B.; Nichols, D. E., and Mclaughlin, J. L. Brine Shrimp: a Convenient General Bioassay for Active Plant Constituents Planta Med. 1982, 45, 31–34 doi:10.1055/s-2007-971236.
   PubMed Web of Science ®Google Scholar
• Sánchez-Moreno, C.; Larrauri, J. A.; Saura-Calixto, F. A Procedure to Measure the Antiradical Efficiency of Polyphenols. J. Sci. Food Agric. 1998, 76(2), 270–276. DOI: 10.1002/(SICI)1097-0010(199802)76:2<270::AID-JSFA945>3.0.CO;2-9.
   Web of Science ®Google Scholar
• Ruch, R. J.; Jun Cheng, S.; Klaunig, J. E. Prevention of Cytotoxicity and Inhibition of Intercellular Communication by Antioxidant Catechins Isolated from Chinese Green Tea. Carcinogenesis. 1989, 10(6), 1003–1008. DOI: 10.1093/carcin/10.6.1003.
   PubMed Web of Science ®Google Scholar
• Marvibaigi, M.; Amini, N.; Supriyanto, E.; Majid, F. A. A.; Jaganathan, S. K.; Jamil, S.; Hamzehalipour Almaki, J., and Nasiri, R. Antioxidant Activity and ROS-dependent Apoptotic Effect of Scurrula Ferruginea (Jack) Danser Methanol Extract in Human Breast Cancer Cell MDA-MB-231. PLoS One. 2016, 11(7), e0158942 doi:10.1371/journal.pone.0158942.
   PubMed Web of Science ®Google Scholar
• Zhang, Y. J.; Gan, R. Y.; Li, S.; Zhou, Y.; Li, A. N.; Xu, D.-P., and Li, H.-B. Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases. Molecules. 2015, 20(12), 21138–21156 doi:10.3390/molecules201219753.
   PubMed Web of Science ®Google Scholar
• Mahmood, N.; Nazir, R.; Khan, M.; Khaliq, A.; Adnan, M.; Ullah, M., and Yang, H. Antibacterial Activities, Phytochemical Screening and Metal Analysis of Medicinal Plants: traditional Recipes Used against Diarrhea. Antibiotics. 2019, 8(4), 194 doi:10.3390/antibiotics8040194.
   Google Scholar
• Dushimemaria, F.; Du Preez, I. D.; Mumbengegwi, D. R. Randomized Anticancer And Cytotoxicity Activities Of Guibourtia Coleosperma And Diospyros Chamaethamnus. African J. Tradit. Complement. Altern. Med. Ajtcam. 2017, 14(4), 1–7. DOI: 10.21010/ajtcam.v14i4.1.
   PubMedGoogle Scholar
• Chew, A. L.; Jessica, J. J. A.; Sasidharan, S. Antioxidant and Antibacterial Activity of Different Parts of Leucas Aspera. Asian Pac. J. Trop. Biomed. 2012, 2(3), 176–180. DOI: 10.1016/S2221-1691(12)60037-9.
   PubMedGoogle Scholar
• Bavarva, J. H.; Narasimhacharya, A. V. R. L. Leucas Cephalotes Regulates Carbohydrate and Lipid Metabolism and Improves Antioxidant Status in IDDM and NIDDM Rats. J. Ethnopharmacol 2010, 127(1), 98–102. DOI: 10.1016/j.jep.2009.09.042.
   PubMed Web of Science ®Google Scholar
• Rahman, M. S.; Alam, M. B.; Choi, Y. H.; Yoo, J. C. Anticancer Activity and Antioxidant Potential of Aponogeton Undulatus against Ehrlich Ascites Carcinoma Cells in Swiss Albino Mice. Oncol. Lett 2017, 14(3), 3169–3176. DOI: 10.3892/ol.2017.6484.
   PubMed Web of Science ®Google Scholar
• Rahi, M. S.; Islam, M. S.; Jerin, I.; Jahangir, C. A., and Hasan, M. M. Differential Expression of Bax-Bcl-2 and PARP-1 Confirms Apoptosis of EAC Cells in Swiss Albino Mice by Morus Laevigata. J. Food Biochem 2020, 44(8). doi:10.1111/jfbc.13342
   PubMed Web of Science ®Google Scholar
• Kandil, A. S.; Abou-Elella, F.; El Shemy, H. A. Cytotoxic Profile Activities of Ethanolic and Methanolic Extracts of Chicory Plant (Cichorium Intybus L.). J. Radiat. Res. Appl. Sci 2019, 12(1), 106–111. DOI: 10.1080/16878507.2019.1594136.
   Web of Science ®Google Scholar
• Rana, S.; Rahman, S.; Sana, S.; Biswas, T. K., and Hashem, A. K. M. Anticancer Potential of Chenopodium Album Leaf Extract against Ehrlich Ascites Carcinoma Cells in Swiss Albino Mice. Futur. J. Pharm. Sci. 2020, 6(1), 65. DOI: 10.1186/s43094-020-00080-8
   Web of Science ®Google Scholar
• Nam, G. H.; Jo, K. J.; Park, Y. S.; Kawk, H. W.; Kim, S. Y., and Kim, Y. M. In Vitro and in Vivo induction of p53-dependent Apoptosis by Extract of Euryale Ferox Salisbin A549 Human Caucasian Lung Carcinoma Cancer Cells Is Mediated through Akt Signaling Pathway. Front. Oncol. 2019, 9, 406. doi:10.3389/fonc.2019.00406
   PubMed Web of Science ®Google Scholar
• ZHANG, J. H.; XU, M. DNA Fragmentation in Apoptosis. Cell Res 2000, 10(3), 205–211. DOI: 10.1038/sj.cr.7290049.
   PubMed Web of Science ®Google Scholar
• Miah, M.; Shimu, A. S.; Mahmud, S.; Omar, F. B.; Khatun, R., Mohanto, S. C.; Hoque, K. M. F., and Reza, M. A. Methanolic Bark Extract of Abroma Augusta (L.) Induces Apoptosis in EAC Cells through Altered Expression of Apoptosis Regulatory Genes. Evidence-based Complement. Altern. Med 2020, 2020, 1–14. DOI: 10.1155/2020/9145626.
   Web of Science ®Google Scholar