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Toxicology Methods Volume 10, 2000 - Issue 4
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Research Article

A RAPID METHOD FOR QUANTITATING THE EXTENT OF DNA DAMAGE INDUCED BY SULFUR MUSTARD IN HUMAN LYMPHOCYTES FOR DRUG SCREENING

Henry Louis Meier U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA
Pages 251-263 | Published online: 30 Sep 2008

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  • Meier, H. L. 1996. The time-dependent effect of 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD, 1,1'-thiobis [2-chloroethane]) on the lymphocyte viability and the kinetics of protection by poly (ADP-ribose) polymerase inhibitors. Cell Biol. Toxicol. 12:147-153.
  • Meier, H. L., Clayson, E. T, Kelly, S. A., and Corun, C. M. 1996. Effect of sulfur mustard (HD) on ATP levels of human lymphocytes cultured in vitra In Vitro. Toxicol. 9:135-139.
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  • Meier, H. L., and Johnson, J. B. 1992. Inhibitors of poly (ADP-ribose) polymerase prevent the cytotoxic effects induced in human lymphocytes by the alkylating agent, 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD). Toxicol. Appl. Pharmacol. 113:234-239.
  • Meier, H. L., Lusco, C. T, Gross, C. L., Graham, L. M., Krebs, R. C., and Johnson, J. B. 1987. Human lymphocytes as a model for sulfur mustard toxicity. Toxicologist 7:168.
  • Meier, H. L., and Millard, C. B. 1998. Alterations in human lymphocyte DNA caused by sulfur mustard can be mitigated by selective inhibitors of poly (ADP-ribose) polymerase. Biochim. Biophys.Acta 1404:367-376.
  • Millard, C. B., Meier, H. L., and Broomfield, C. A. 1994. Exposure of human lymphocytes to bis(2-chloroethyl) sulfide solubilizes truncated and intact core histones. Biochim. Biophys. Acta 1224:389-394.
  • Moser, J., and Meier, H. L. 1998. The comparison of keratinocytes and lymphocytes on sulfur mustard-dependent changes in cell yield and viability. Int. J. Toxicol. 17:1-18.
  • Moser, J., and Meier, H. L. (in press). A comparison of cell size in sulfur mustard-induced death of keratinocytes and lymphocytes. J. Applied Toxicol.
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