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Toxicology Methods Volume 7, 1997 - Issue 1
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Research Article

Use of a Precise Intratracheal Delivery System to Compare the Acute Tolerance of Heparin and the Heparinoid GM2000 in Rabbits

Patricia D. Williams, David J. Tyrrell, Neal E. Storm, and Kevin R. Holme Roula Salame and Christopher Banks Glycomed Inc., Alameda, California, USA; Bio-Research Laboratori es Ltd., Senneville , Quebec, Canada
Pages 1-7 | Published online: 30 Sep 2008

REFERENCES

  • Tyrrell DJ, Kilfeather S, Page C. Therapeutic uses of heparin beyond its traditional role as an anticoagulant. Trends Pharm Sci, 1995; 16:198–204.
  • Lindahl U, Lidholt K, Spillmann D, Kjellen L. More to heparin than anticoagulation. Thromb Res. 1994;75:1–32.
  • Page CP. One explanation of the asthma paradox: inhibition of natural anti-inflammatory mechanism by B2-agonists. Lancet. 1991;337:717–720.
  • Bowler SD, Smith SM, Lavercombe PS. Heparin inhibits the immediate response to antigen in the skin and lungs of allergic rabbits. Am Rev Respir Dis. 1993; 147:160–163.
  • Ahmed T, Garrigo J, Danta I. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N Engl J Med. 1993;329:90–95.
  • Garrigo J, Danta I, Ahmed T. Time course of heparin on exercise-induced asthma. Am J Respir Crit Care Med. 1996;153:1702–1707.
  • Diamant Z, Timmers MC, Van der Veen H, Page CP, Van der Meer FJ, Stark PJ. Effect of inhaled heparin on allergen-induced early and late asthmatic responses in patients with atopic asthma. Am J Respir Crit Med. 1996; 153:1790–1795.
  • Ongoing studies at Glycomed Inc., Alameda, CA (David Tyrrell, PhD).
  • Dolowitz DA, Dougherty TF. The use of heparin in the control of allergies. Ann Allergy. 1965; 23:309–313.

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