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Research Article

HPLC DETERMINATION OF TRITIATED POLYCYCLIC AROMATIC HYDROCARBON METABOLITES IN THE SUBFEMTOMOLE RANGE

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Pages 17-25 | Published online: 30 Sep 2008

  • Madhavan ND, Naidu KA. Polycycyclic aromatic hydrocarbons in placenta, maternal blood, umbilical cord blood and milk of Indian women. Hum Exp Toxicol. 1995; 14:503-506.
  • Alexandrov K, Rojas M, Golberg M, Camus AM, Bartsch H. Anew sensitive fluorometricassay for the metabolism of (-)-7-8,-dihydroxy-7,8,-dihydrobenzo[a]pyrene by human hair follicles. Carcinogenesis. 1990;11:2157-2161.
  • Likhachev AJ, Beniashvili DA, Bykov VJ, et al. Biomarkers for individual susceptibility to carcinogenic agents: excretion and carcinogenic risk of benzo[a]pyrene metabolites. Environ Health Perspect. 1992;98:211-214.
  • Saito Y, Sekita H, Takeda M, Uchiyama M. Determination of benzo[a]pyrene in foods. J Assoc Anal Chem. 1978;61:129-135.
  • Gomes M, Santella RM. Immunologie methods for detection of benzo[a]pyrene metabolites in urine. Chem Res Toxicol. 1990;3:307-310.
  • Westen A, Bowman ED, Carr P, Rothman N, Strick land PT. Detection of metabolites of poly cyclic aromatic hydrocarbons in human urine. Carcinogenesis. 1993;14:1053-1055.
  • Strickland PT, Kang D, Bowman ED, et al. Identification of 1 -hydroxypyrene glucuronide as a major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatography-mass spectrometry. Carcinogenesis. 1994; 15:483-487.
  • Hansen AM, Poulsen OM, Christensen J M. Determination of l -hydroxypyrene in human urine by high-performance liquid chromatography. J Anal Taxicol. 1993;17:38-41.
  • Jongeneelen FJ, Anzion RBM, Henderson PT. Determination of hydroxylated metabolites of polycyclichydrocarbons in urine. J Chromatogr. 1987;413:227-232.
  • Lintelmann J, Hellemann C, Kettrup A. Coupled-column high-performance liquid Chromatographie method for the determination of four metabolites of polycyclic aromatic hydrocarbons, 1-, 4-, and 9-hydroxyphenanthrene and 1-hydroxypyrene, in urine. J Chromatog. 1994;660:6773.
  • Gerde P, Muggenburg BA, Thornton-Manning JR, Lewis JL, Pyon KH, Dahl AR. Benzofa]pyrene at an environmentally relevant dose is s lowly absorbed by and extensively metabolized in tracheal epithelium. Carcinogenesis. 1997;18:1825-1832.
  • Dahl AR, Benson J M, Hanson RL, Rothenberg SJ. The fractionation of environmental samples according to volatility by vacuum line-cryogenicdistillation. Am Ind Hyg Assoc J. 1984;45:193198.
  • Aarstad K, Toftgard R, Nilsen OG. A comparison of the binding and distribution of benzofa]pyrene in human and rat serum. Toxicology. 1987;47:235-245.
  • Van de Wiel J AG, Fijneman PHS, Duijf CMP, Anzion RBM, Theuws JLG, Bos RP. Excretion of benzo[a]pyrene and metabolites in urine and feces of rats: influence of route of administration, sex and long-term ethanol treatment. Toxicology. 1993;80:103-115.
  • Uziel M, Haglund R. Persistence of benzo[a]pyrene and 7,8-dihydro-7,8-dihydroxybenzo[a]pyrene in Fischer F344 rats: time distribution of total metabolites in blood, urine, and feces. Carcinogenesis. 1988;9:233-238.
  • Mitchell CE. The metabolic fate of benzo[a]pyrene in rats after inhalation. Toxicology. 1983;28: 65-73.
  • Weyand EH, Bevan DR. Benzo[a]pyrene disposition and metabolism in rats following intrat radical instillation. Cancer Res. 1986;46:5655-5661.
  • Foth H, Kahl R, Kahl GF. Pharmacokinetics of low doses of benzo[a]pyrene in the rat. Fed Chem Toxicol. 1988;26:45-51.
  • Bevan DR, Ulman MR. Examination of factors that may influence disposition of benzo[a]pyrene in viva vehicles and asbestos. Cancer Lett. 1991;57:173-179.
  • Bevan DR, Sadler VM. Quinol diglucuronides are predominant conjugated metabolites found in bile of rats following intratracheal instillation of benzd(a]pyrene. Carcinogenesis. 1992; 13:403407.
  • Withey J, Shedden J, Law FCP, Abedini S. Distribution of benzo[a]pyrene in pregnant rats following inhalation exposure and a comparison with similar data obtained with pyrene. J Appl Toxicol. 1993;13:193-202.

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