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Toxicology Methods Volume 9, 1999 - Issue 4
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Research Article

VERIFICATION OF LEWISITE EXPOSURE BY THE ANALYSIS OF 2-CHLOROVINYL ARSONOUS ACID IN URINE

Thomas Logan Dru g Asses sment Division, U.S. Army Medical Resear ch Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA
,
Smith Richard Dru g Asses sment Division, U.S. Army Medical Resear ch Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA
,
Jakubowski Edward Dru g Asses sment Division, U.S. Army Medical Resear ch Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA
&
Nielson Ronald Dru g Asses sment Division, U.S. Army Medical Resear ch Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA
Pages 275-284 | Published online: 30 Sep 2008

  • Bartlett, P. D. 1942. Reaction of M-I (lewisite) with dithiols and other thio agents. Office of Scientific Research and Development Report Na 402, RG 227, Div. 9, Feb. 20, 1942, Harvard University (1942), pp. 1-11.
  • Cameron, G. R., Carleton, H. M., and Short, R. H. D. 1946. Pathological changes induced by lewisite and allied compounds. /. Pathol. Bact. 58:411-422.
  • Culien, W. R., Eigendorf, G. K., and Pergantis, S. A. 1993. Desorption chemical ionization mass spectrometry of arsenic com pounds in the marine and terrestial environment. Rapid Commun. Mass Spectrom. 7:33-36.
  • Edgewood Arsenal Special Report #EO-SR-74001, "Chemical Agent Data Sheets, Vol. I", Edgewood Arsenal, APG, MD, Dec. 1974, p. 68. ADB028222L.
  • Fowler, W. K., Stewart, D. C., Weinberg, D. S., and Sarver, E. W. 1991. Gas Chromatographie determination of the lewisite hydrolysate, 2-chlorovinylarsonous acid, after derivatization with 1,2-ethanedithiol. J. Chromatogr., 558, 235-246.
  • Inns, R. H., Bright, J. E., and Marrs, T. C. 1988. Comparative acute systemic toxicity of sodium arsenite and dichloro(2-chlorovinyl)arsine in rabbits. Toxicology 51:213-222.
  • Jakubowski, E. M., Woodard, C. L., Mershon, M. M., and Dolzine, T. W. 1990. Quantification of thiodiglycol in urine by electron ionization gas chromatography-mass spectrometry. J. Chromatogr. 528:184-190.
  • Jakubowski, E. M., Smith, J. R., Logan, T. P., Wiltshire, N. D., Woodard, C. L., Evans, R. A., and Dolzine, T. W. 1993. Verification of lewisite exposure: quantification of chlorovinylarsonous acid in biological samples. Proceedings of the 1993 Medical Defense Bioscience Review, U.S. Army Medical Research Institute of Chemical Defense, APG, MD, 10-13 May, pp. 361-368. ADA275667.
  • Logan, T. P., Smith, J. R., Jakubowski, E. M., and Dolzine, T. W. 1993. Quantitation of lewisite prepared in organic solutions using gas chromatography. USAMRICD-TR-93-03, U.S. Army Medical Research Institute of Chemical Defense, APG, MD, June 1993. ADA#A270723.
  • Shih, M. L., Smith, J. R., McMonagle, J. D., Dolzine, T. W., and Gresham, V. C. 1991. Detection of metabolites of toxic alkylmethylphosphonates in biological samples. Biol. Mass Spectrom. 20:717-723.
  • Snider, T. H., Wientjes, M. G., Joiner, R. L., and Fisher, G. L. 1990. Arsenic distribution in rabbits after lewisite administration and treatment with British anti-lewisite (BAL). Fundam. Appl. Toxicol. 14:262-272.
  • Waters, W. A., and Williams, J. H. 1950. Hydrolyses and derivatives of some vesicant arsenicale. J. Chem. Soc. 18-22.

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