Effects of metformin on lipopolysaccharide induced inflammation by activating fibroblast growth factor 21

References

• Alirezaei M, Dezfoulian O, Kheradmand A. 2015. Novel antioxidant properties of ghrelin and oleuropein versus lipopolysaccharide-mediated renal failure in rats. Int J Pept Res Ther. 21:411–421. doi:10.1007/s10989-015-9470-z.
   Web of Science ®Google Scholar
• Bal F, Bekpinar S, Unlucerci Y, Kusku-Kiraz Z, Onder S, Uysal M, Gurdol F. 2014. Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury. Diabetes Res Clin Pract. 106:295–302. doi:10.1016/j.diabres.2014.08.028.
   PubMed Web of Science ®Google Scholar
• Barton GM. 2008. A calculated response: control of inflammation by the innate immune system. J Clin Invest. 118:413–420. doi:10.1172/JCI34431.
   PubMed Web of Science ®Google Scholar
• Chen W, Liu X, Ye S. 2016. Effects of metformin on blood and urine pro-inflammatory mediators in patients with type 2 diabetes. J Inflam. 13:1–6. doi:10.1186/s12950-016-0142-3.
   Google Scholar
• Cho YK, Choi YH, Kim SH, Lee MG. 2009. Effects of Escherichia coli lipopolysaccharide on the metformin pharmacokinetics in rats. Xenobiotica. 39:946–954. doi:10.3109/00498250903215994.
   PubMed Web of Science ®Google Scholar
• Cicione C, Degirolamo C, Moschetta A. 2012. Emerging role of fibroblast growth factors 15/19 and 21 as metabolic ıntegrators in the liver. Hepatology. 56:2404–2411. doi:10.1002/hep.25929.
   PubMed Web of Science ®Google Scholar
• Cuevas-Ramos D, Aguilar-Salinas CA, Gomez-Perez FJ. 2012. Metabolic actions of fibroblast growth factor 21. Curr Opin Ped. 24:523–529. doi:10.1097/MOP.0b013e3283557d22.
   PubMed Web of Science ®Google Scholar
• Depboylu B, Giris M, Olgac V, Dogru-Abbasoglu S, Uysal M. 2013. Response of liver to lipopolysaccharide treatment in male and female rats. Exp Toxicol Pathol. 65:645–650. doi:10.1016/j.etp.2012.07.004.
   PubMedGoogle Scholar
• Er A, Yazar E, Uney K, Elmas M, Altan F, Cetin G. 2010. Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide-treated mice. Acta Vet Hung. 58:75–81. doi:10.1556/avet.58.2010.1.8.
   PubMed Web of Science ®Google Scholar
• Fan H, Sun X, Zhang H, Liu J, Zhang P, Xu Y, Wang G. 2016. Effect of metformin on fibroblast growth factor-21 levels in patients with newly diagnosed type 2 diabetes. Diabetes Technol Ther. 18:120–126. doi:10.1089/dia.2015.0261.
   PubMed Web of Science ®Google Scholar
• Faraj TA, McLaughlin CL, Erridge C. 2017. Host defenses against metabolic endotoxemia and their impact on lipopolysaccharide detection. Int Rev Immunol. 36:125–144. doi:10.1080/08830185.2017.1280483.
   PubMed Web of Science ®Google Scholar
• Feingold KR, Grunfeld C, Heuer JG, Gupta A, Cramer M, Zhang T, Kharitonenkov A. 2012. FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis. Endocrinology. 153:2689–2700. doi:10.1210/en.2011-1496.
   PubMed Web of Science ®Google Scholar
• Feldman AT, Wolfe D. 2014. Tissue processing and hematoxylin and eosin staining. In: Day C, Ed., Histopathology. Methods in molecular biology (methods and protocols). Vol. 1180. Humana Press: New York, NY; p. 31–43.
   Google Scholar
• Gnauck A, Lentle RG, Kruger MC. 2016. The characteristics and function of bacterial lipopolysaccharides and their endotoxic potential in humans. Int Rev Immunol. 35:189–218. doi:10.3109/08830185.2015.1087518.
   PubMed Web of Science ®Google Scholar
• Gornall AG, Bardawill CJ, David MM. 1949. Determination of serum proteins by means of the biuret reaction. J Biol Chem. 177:751–766. doi:10.1016/S0021-9258(18)57021-6.
   PubMed Web of Science ®Google Scholar
• Grutz G. 2005. New insights into the molecular mechanism of interleukin-10-mediated immunosuppression. J Leuk Biol. 77:3–15. doi:10.1189/jlb.0904484.
   PubMed Web of Science ®Google Scholar
• Haugaard N. 1968. Cellular mechanisms of oxygen toxicity. Physiol Rev. 48:311–373. doi:10.1152/physrev.1968.48.2.311.
   PubMed Web of Science ®Google Scholar
• Hyun B, Shin S, Lee A, Lee S, Song Y, Ha NJ, Kim K. 2013. Metformin down-regulates TNF-alpha secretion via suppression of scavenger receptors in macrophages. Immune Netw. 13:123–132. doi:10.4110/in.2013.13.4.123.
   PubMedGoogle Scholar
• Kalaz EB, Aydin AF, Dogan-Ekici I, Coban J, Dogru-Abbasoglu S, Uysal M. 2016. Protective effects of carnosine alone and together with alpha-tocopherol on lipopolysaccharide (LPS) plus ethanol-induced liver injury. Env Toxicol Pharmacol. 42:23–29. doi:10.1016/j.etap.2015.12.018.
   PubMed Web of Science ®Google Scholar
• Kar E, Alataş İÖ, Şahintürk V, Öz S. 2018. Early treatment with metformin decreases pancreatic damage in rats with LPS induced sepsis. Türk Yasam Bilimleri Derg. 3:194–199.
   Google Scholar
• Kar F, Hacioglu C, Senturk H, Burukoglu Donmez D, Kanbak G. 2020. The role of oxidative stress, renal ınflammation, and apoptosis in post ıschemic reperfusion ınjury of kidney tissue: the protective effect of dose-dependent boric acid administration. Biol Trace Elem Res. 195:150–158. doi:10.1007/s12011-019-01824-1.
   PubMed Web of Science ®Google Scholar
• Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, Tigno XT, Etgen GJ. 2007. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology. 148:774–781. doi:10.1210/en.2006-1168.
   PubMed Web of Science ®Google Scholar
• Kim KH, Jeong YT, Kim SH, Jung HS, Park KS, Lee HY, Lee MS. 2013. Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation. Biochem Biophys Res Commun. 440:76–81. doi:10.1016/j.bbrc.2013.09.026.
   PubMed Web of Science ®Google Scholar
• Kim SA, Choi HC. 2012. Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells. Biochem Biophys Res Commun. 425:866–872. doi:10.1016/j.bbrc.2012.07.165.
   PubMed Web of Science ®Google Scholar
• Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Ramsay G. 2003. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med. 31:1250–1256. doi:10.1097/01.CCM.0000050454.01978.3B.
   PubMed Web of Science ®Google Scholar
• Lien F, Berthier A, Bouchaert E, Gheeraert C, Alexandre J, Porez G, Lucas A. 2014. Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk. J Clin Invest. 124:1037–1051. doi:10.1172/JCI68815.
   PubMed Web of Science ®Google Scholar
• Liu C, Tang X, Zhang W, Li G, Chen Y, Guo A, Hu C. 2019. 6-Bromoindirubin-3′-oxime suppresses LPS-induced inflammation via inhibition of the TLR4/NF-κB and TLR4/MAPK signaling pathways. Inflammation. 42:2192–2204. doi:10.1007/s10753-019-01083-1.
   PubMed Web of Science ®Google Scholar
• Medzhitov R. 2008. Origin and physiological roles of inflammation. Nature. 454:428–435. doi:10.1038/nature07201.
   PubMed Web of Science ®Google Scholar
• Nygaard EB, Vienberg SG, Orskov C, Hansen HS, Andersen B. 2012. Metformin stimulates FGF21 expression in primary hepatocytes. Exp Diabetes Res. Article ID 465282. 2012:1–8. doi:10.1155/2012/465282.
   Google Scholar
• Ohgami K, Shiratori K, Kotake S, Nishida T, Mizuki N, Yazawa K, Ohno S. 2003. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest Ophthal Vis Sci. 44:2694–2701. doi:10.1167/iovs.02-0822.
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:351–358. doi:10.1016/0003-2697(79)90738-3.
   PubMed Web of Science ®Google Scholar
• Olleros ML, Martin ML, Vesin D, Fotio AL, Santiago-Raber ML, Rubbia-Brandt L, Garcia I. 2008. Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines. Cytokine. 44:118–125. doi:10.1016/j.cyto.2008.07.001.
   PubMed Web of Science ®Google Scholar
• Opoku YK, Liu Z, Afrifa J, Khoso MH, Ren G, Li D. 2020. Therapeutic role of fibroblast growth factor 21 (FGF21) in the amelioration of chronic diseases. Int J Pept Res Ther. 26:107–119. doi:10.1007/s10989-019-09820-8.
   Web of Science ®Google Scholar
• Pandey A, Kumar VL. 2016. Protective effect of metformin against acute ınflammation and oxidative stress in rat. Drug Dev Res. 77:278–284. doi:10.1002/ddr.21322.
   PubMed Web of Science ®Google Scholar
• Pengal RA, Ganesan LP, Wei G, Fang H, Ostrowski MC, Tridandapani S. 2006. Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt. Mol Immunol. 43:1557–1564. doi:10.1016/j.molimm.2005.09.022.
   PubMed Web of Science ®Google Scholar
• Planavila A, Redondo-Angulo I, Ribas F, Garrabou G, Casademont J, Giralt M, Villarroya F. 2015. Fibroblast growth factor 21 protects the heart from oxidative stress. Cardiovasc Res. 106:19–31. doi:10.1093/cvr/cvu263.
   PubMed Web of Science ®Google Scholar
• Presta M, Chiodelli P, Giacomini A, Rusnati M, Ronca R. 2017. Fibroblast growth factors (FGFs) in cancer: FGF traps as a new therapeutic approach. Pharmacol Ther. 179:171–187.
   PubMed Web of Science ®Google Scholar
• Quaile MP, Melich DH, Jordan HL, Nold JB, Chism JP, Polli JW, Rhodes MC. 2010. Toxicity and toxicokinetics of metformin in rats. Toxicol Appl Pharmacol. 243:340–347. doi:10.1016/j.taap.2009.11.026.
   PubMed Web of Science ®Google Scholar
• Saisho Y. 2015. Metformin and Inflammation: ıts potential beyond glucose-lowering effect. Endocr Metab Immune Disord Drug Targ. 15:196–205. doi:10.2174/1871530315666150316124019.
   PubMed Web of Science ®Google Scholar
• Salman ZK, Refaat R, Selima E, El Sarha A, Ismail MA. 2013. The combined effect of metformin and L-cysteine on inflammation, oxidative stress and insulin resistance in streptozotocin-induced type 2 diabetes in rats. Eur J Pharmacol. 714:448–455. doi:10.1016/j.ejphar.2013.07.002.
   PubMed Web of Science ®Google Scholar
• Singhal G, Douris N, Fish AJ, Zhang XY, Adams AC, Flier JS, Maratos-Flier E. 2016. Fibroblast growth factor 21 has no direct role in regulating fertility in female mice. Mol Metab. 5:690–698. doi:10.1016/j.molmet.2016.05.010.
   PubMed Web of Science ®Google Scholar
• Stearns-Kurosawa DJ, Osuchowski MF, Valentine C, Kurosawa S, Remick DG. 2011. The pathogenesis of sepsis. Ann Rev Pathol. 6:19–48. doi:10.1146/annurev-pathol-011110-130327.
   PubMed Web of Science ®Google Scholar
• Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE. 1995. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med. 333:550–554. doi:10.1056/NEJM199508313330903.
   PubMed Web of Science ®Google Scholar
• Suzuki K, Ota H, Sasagawa S, Sakatani T, Fujikura T. 1983. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem. 132:345–352. doi:10.1016/0003-2697(83)90019-2.
   PubMed Web of Science ®Google Scholar
• Tuzlalı S, Güllüoğlu M, Çevikbaş U. 2014. Robbins temel patoloji. Nobel Kitabevi: Istanbul; p. 29–31.
   Google Scholar
• Vaez H, Rameshrad M, Najafi M, Barar J, Barzegari A, Garjani A. 2016. Cardioprotective effect of metformin in lipopolysaccharide-induced sepsis via suppression of toll-like receptor 4 (TLR4) in heart. Eur J Pharmacol. 772:115–123. doi:10.1016/j.ejphar.2015.12.030.
   PubMed Web of Science ®Google Scholar
• Vincent JL, Opal SM, Marshall JC, Tracey KJ. 2013. Sepsis definitions: time for change. Lancet. 381:774–775. doi:10.1016/S0140-6736(12)61815-7.
   PubMed Web of Science ®Google Scholar
• Viollet B, Guigas B, Sanz Garcia N, Leclerc J, Foretz M, Andreelli F. 2012. Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond.). 122:253–270. doi:10.1042/CS20110386.
   PubMed Web of Science ®Google Scholar
• Wang Y, Dang N, Sun P, Xia J, Zhang C, Pang S. 2017. The effects of metformin on fibroblast growth factor 19, 21 and fibroblast growth factor receptor 1 in high-fat diet and streptozotocin induced diabetic rats. Endocr J. 64:543–552. doi:10.1507/endocrj.EJ16-0391.
   PubMed Web of Science ®Google Scholar
• Yan D, Liu HL, Yu ZJ, Huang YH, Gao D, Hao H, Zhou XY. 2016. BML-111 protected LPS/D-GalN-ınduced acute liver ınjury in rats. Int J Mol Sci. 17:1114–1127. doi:10.3390/ijms17071114.
   Web of Science ®Google Scholar
• Yu YH, He JJ, Li SM, Song LY, Guo XC, Yao WB, Li DS. 2016. Fibroblast growth factor 21 (FGF21) inhibits macrophage -mediated inflammation by activating Nrf2 and suppressing the NF-kappa B signaling pathway. Int Immunopharmacol. 38:144–152. doi:10.1016/j.intimp.2016.05.026.
   PubMed Web of Science ®Google Scholar
• Yuan H, Li L, Zheng W, Wan J, Ge P, Li H, Zhang L. 2012. Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice. Int Immunopharmacol. 12:682–688. doi:10.1016/j.intimp.2012.01.015.
   PubMed Web of Science ®Google Scholar
• Zhang M, Liu Y, Xiong ZY, Deng ZY, Song HL, An ZM. 2013. Changes of plasma fibroblast growth factor-21 (FGF-21) in oral glucose tolerance test and effects of metformin on FGF-21 levels in type 2 diabetes mellitus. Endokr Pol. 64:220–224.
   PubMed Web of Science ®Google Scholar