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Articles

Carvacrol protects rat liver exposed to formaldehyde by regulating oxidative stress, and asprosin and subfatin hormones

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References

  • Akkoc RF, Ogeturk M, Aydin S, Kuloglu T, Aydin S. 2021. Effects of carnosine on apoptosis, transient receptor potential melastatin 2 and betatrophin in rats exposed to formaldehyde. Biotech Histochem. 96:223–229. doi:10.1080/10520295.2020.1783571
  • Arunasree KM. 2010. Anti-proliferative effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231. Phytomedicine. 17:581–588. doi:10.1016/j.phymed.2009.12.008
  • Aydin S. 2007. A comparison of ghrelin, glucose, alpha-amylase and protein levels in saliva from diabetics. J Biochem Mol Biol. 40:29–35. doi:10.5483/BMBRep.2007.40.1.029
  • Aydin S, Ogeturk M, Kuloglu T, Kavakli A, Aydin S. 2015. Effect of carnosine supplementation on apoptosis and irisin, total oxidant and antioxidants levels in the serum, liver and lung tissues in rats exposed to formaldehyde inhalation. Peptides. 64:14–23. doi:10.1016/j.peptides.2014.11.008
  • Aydin S, Kuloglu T, Ozercan MR, Albayrak S, Aydin S, Bakal U, Yilmaz M, Kalayci M, Yardim M, Sarac M, Kazez A, Kocdor H, Kanat B, Ozercan İH, Gonen M, Bilgen M, Balgetir F. 2016. Irisin immunohistochemistry in gastrointestinal system cancers. Biotech Histochem. 91:242–250. doi:10.3109/10520295.2015.1136988
  • Bakar E, Ulucam E, Cerkezkayabekir A. 2015. Investigation of the protective effects of proanthocyanidin and vitamin E against the toxic effect caused by formaldehyde on the liver tissue. Env Toxicol. 30:1406–1415. doi:10.1002/tox.22010
  • Bhakkiyalakshmi E, Suganya N, Sireesh D, Krishnamurthi K, Devi SS, Rajaguru P, Ramkumar KM. 2016. Carvacrol induces mitochondria-mediated apoptosis in HL-60 promyelocytic and Jurkat T lymphoma cells. Eur J Pharmacol. 772:92–98. doi:10.1016/j.ejphar.2015.12.046
  • Cho S, Choi Y, Park S, Park T. 2012. Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet. J Nutr Biochem. 23:192–201. doi:10.1016/j.jnutbio.2010.11.016
  • Dagli Gul AS, Fadillioglu E, Karabulut I, Yesilyurt A, Delibasi T. 2013. The effects of oral carvacrol treatment against H2O2 induced injury on isolated pancreas islet cells of rats. Islets. 5:149–155. doi:10.4161/isl.25519
  • Fan K, Li X, Cao Y, Qi H, Li L, Zhang Q, Sun H. 2015. Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells. Anticancer Drugs. 26:813–823. doi:10.1097/CAD.0000000000000263
  • Gommers LMM, Hill TG, Ashcroft FM, de Baaij JHF. 2019. Low extracellular magnesium does not impair glucose-stimulated insulin secretion. PLoS One. 14:e0217925. doi:10.1371/journal.pone.0217925
  • Gong Y, Wei Y, Cheng J, Jiang T, Chen L, Xu B. 2017. Health risk assessment and personal exposure to volatile organic compounds (VOCs) in metro carriages–a case study in Shanghai, China. Sci Total Env. 574:1432–1438. doi:10.1016/j.scitotenv.2016.08.072
  • Jung WW, Kim EM, Lee EH, Yun HJ, Ju HR, Jeong MJ, Hwang KW, Sul D, Kang HS. 2007. Formaldehyde exposure induces airway inflammation by increasing eosinophil infiltrations through the regulation of reactive oxygen species production. Env Toxicol Pharmacol. 24:174–182. doi:10.1016/j.etap.2007.05.001
  • Karkabounas S, Kostoula OK, Daskalou T, Veltsistas P, Karamouzis M, Zelovitis I, Metsios A, Lekkas P, Evangelou AM, Kotsis N, Skoufos I. 2006. Anticarcinogenic and antiplatelet effects of carvacrol. Exp Oncol. 28:121–125.
  • Koparal AT, Zeytinoglu M. 2003. Effects of carvacrol on a human non-small cell lung cancer (NSCLC) cell line, A549. Cytotechnology. 43:149–154. doi:10.1023/B:CYTO.0000039917.60348.45
  • Köse E, Sarsılmaz M, Meydan S, Pekmez H, Dabak DÖ, Kavaklı A, Ögetürk M. 2010. Solunum Yoluyla Formaldehit ve Lavanta Uygulanan Sıçan Testislerinin Değerlendirilmesi; Bir Histolojik Çalışma. İnönü Üniv Tıp Fak Derg. 17:169–173.
  • Kum S, Sandikçİ M, Eren Ü, Metin N. 2010. Effects of formaldehyde and xylene inhalations on fatty liver and kidney in adult and developing rats. J Anim Vet Adv. 9:396–401. doi:10.3923/javaa.2010.396.401
  • Lee T, Yun S, Jeong JH, Jung TW. 2019. Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation. Mol Cell Endocrinol. 486:96–104. doi:10.1016/j.mce.2019.03.001
  • Li ZY, Zheng SL, Wang P, Xu TY, Guan YF, Zhang YJ, Miao CY. 2014. Subfatin is a novel adipokine and unlike meteorin in adipose and brain expression. CNS Neurosci Ther. 20:344–354. doi:10.1111/cns.12219
  • Li ZY, Song J, Zheng SL, Fan MB, Guan YF, Qu Y, Xu J, Wang P, Miao CY. 2015. Adipocyte metrnl antagonizes insulin resistance through PPARγ signaling. Diabetes. 64:4011–4022. doi:10.2337/db15-0274
  • Liu T, Bai XT. 2005. Effect of formaldehyde on energy metabolism in postnatal rat cortex neurons in culture. Wei Sheng Yan Jiu. 34:275–277.
  • Liu Y, Wei J, Ma KT, Li CL, Mai YP, Qiu XX, Wei H, Hou N, Luo JD. 2020. Carvacrol protects against diabetes-induced hypercontractility in the aorta through activation of the PI3K/Akt pathway. Biomed Pharmacother. 125:109825. doi:10.1016/j.biopha.2020.109825
  • Mahmoodi M, Amiri H, Ayoobi F, Rahmani M, Taghipour Z, Ghavamabadi RT, Jafarzadeh A, Sankian M. 2019. Carvacrol ameliorates experimental autoimmune encephalomyelitis through modulating pro- and anti-inflammatory cytokines. Life Sci. 219:257–263. doi:10.1016/j.lfs.2018.11.051
  • Merzoug S, Toumi ML. 2017. Effects of hesperidin on formaldehyde-induced toxicity in pregnant rats. J Exp Clin Sci. 16:400–413.
  • Peixoto-Neves D, Silva-Alves KS, Gomes MDM, Lima FC, Lahlou S, Magalhães PJC, Ceccatto VM, Coelho-de-Souza AN, Leal-Cardoso JH. 2010. Vasorelaxant effects of the monoterpenic phenol isomers, carvacrol and thymol, on rat isolated aorta. Fund Clin Pharmacol. 24:341–350. doi:10.1111/j.1472-8206.2009.00768.x
  • Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, Spiegelman BM. 2014. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 157:1279–1291. doi:10.1016/j.cell.2014.03.065
  • Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR. 2016. Asprosin, a fasting-induced glucogenic protein hormone. Cell. 165:566–579. doi:10.1016/j.cell.2016.02.063
  • Schlink K, Janssen K, Nitzsche S, Gebhard S, Hengstler JG, Klein S, Oesch F. 1999. Activity of O6-methylguanine DNA methyltransferase in mononuclear blood cells of formaldehyde-exposed medical students. Arch Toxicol. 73:15–21. doi:10.1007/s002040050581
  • Shaham J, Bomstein Y, Meltzer A, Kaufman Z, Palma E, Ribak J. 1996. DNA-protein crosslinks, a biomarker of exposure to formaldehyde—in vitro and in vivo studies. Carcinogenesis. 17:121–125. doi:10.1093/carcin/17.1.121
  • Strubelt O, Younes M, Pentz R, Kühnel W. 1989. Mechanistic study on formaldehyde-induced hepatotoxicity. J Toxicol Env Health. 27:351–366. doi:10.1080/15287398909531306
  • Suo L, Kang K, Wang X, Cao Y, Zhao H, Sun X, Tong L, Zhang F. 2014. Carvacrol alleviates ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats. PLoS One. 9:e104043. doi:10.1371/journal.pone.0104043
  • Tan T, Zhang Y, Luo W, Lv J, Han C, Hamlin JNR, Luo H, Li H, Wan Y, Yang X, Song W, Tong Z. 2018. Formaldehyde induces diabetes-associated cognitive impairments. FASEB J. 3232:3669–3679. doi:10.1096/fj.201701239R
  • Testai L, Chericoni S, Martelli A, Flamini G, Breschi MC, Calderone V. 2016. Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta. J Pharm Pharmacol. 68:1177–1183. doi:10.1111/jphp.12585
  • Ugur K, Aydin S. 2019. Saliva and blood asprosin hormone concentration associated with obesity. Int J Endocrinol. 2019:2521096. doi:10.1155/2019/2521096
  • Uyanoglu M, Canbek M, Aral E, Baser KHC. 2008. Effects of carvacrol upon the liver of rats undergoing partial hepatectomy. Phytomedicine. 15:226–229. doi:10.1016/j.phymed.2007.06.010
  • Vural O. 2019. Deneysel metotreksat uygulanan sıçanların karaciğer dokularında asprosin immünreaktivitesi üzerine NAS (N-asetilsistein)‘in etkilerinin incelenmesi [dissertation]. Elazig (TR) Fırat University.
  • Wang P, Luo Q, Qiao H, Ding H, Cao Y, Yu J, Liu R, Zhang Q, Zhu H, Qu L. 2017. The neuroprotective effects of carvacrol on ethanol-induced hippocampal neurons impairment via the antioxidative and anti-apoptotic pathways. Oxid Med Cell Longev. 2017:4079425. doi:10.1155/2017/4079425
  • Zararsız İ, Kuş İ, Yılmaz HR, Köse E, Sarsılmaz M. 2008. Deneysel formaldehit toksisitesi sonucu hipokampusta oluşan doku hasarına karşı omega-3 yağ asitlerinin antioksidan etkileri. FÜ Sağ Bil Derg. 22:59–64.
  • Zheng SL, Li ZY, Song J, Liu JM, Miao CY. 2016. Metrnl: a secreted protein with new emerging functions. Acta Pharmacol Sin. 37:571–579. doi:10.1038/aps.2016.9

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