Synergistic apoptotic effects of ethanolic extracts of ginger and Ganoderma lucidum in a colorectal cancer cell line

References

• Barbieri A, Quagliariello V, Del Vecchio V, Falco M, Luciano A, Amruthraj NJ, Nasti G, Ottaiano A, Berretta M, Iaffaioli RV, Arra C. 2017. Anticancer and anti-inflammatory properties of Ganoderma lucidum extract effects on melanoma and triple-negative breast cancer treatment. Nutrients. 9:1–9. doi:10.3390/nu9030210
   Web of Science ®Google Scholar
• Bernard MM, McConnery JR, Hoskin DW. 2017. [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Exp Mol Pathol. 102:370–376. doi:10.1016/j.yexmp.2017.03.006
   PubMed Web of Science ®Google Scholar
• Caldwell GW, Yan Z, Lang W, Masucci JA. 2012. The IC(50) concept revisited. Curr Top Med Chem. 12:1282–1290. doi:10.2174/156802612800672844
   PubMed Web of Science ®Google Scholar
• Cheng S, Sliva D. 2015. Ganoderma lucidum for cancer treatment: we are close but still not there. Integr Cancer Ther. 14:249–257. doi:10.1177/1534735414568721
   PubMed Web of Science ®Google Scholar
• Chou T-C. 2006. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 58:621–681. doi:10.1124/pr.58.3.10
   PubMed Web of Science ®Google Scholar
• Chou T-C. 2010. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 70:440–446. doi:10.1158/0008-5472.CAN-09-1947
   PubMed Web of Science ®Google Scholar
• Gandomani HS, Aghajani M, Mohammadian-Hafshejani A, Tarazoj AA, Pouyesh V, Salehiniya H. 2017. Colorectal cancer in the world: incidence, mortality and risk factors. Biomed Res Ther. 4:1656–1675. doi:10.15419/bmrat.v4i10.372
   Web of Science ®Google Scholar
• Ghasemzadeh A, Jaafar HZ, Rahmat A. 2015. Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology. BMC Comple Alt Med. 15:1–10. doi:10.1186/s12906-015-0718-0
   PubMed Web of Science ®Google Scholar
• Jiao C, Chen W, Tan X, Liang H, Li J, Yun H, He C, Chen J, Ma X, Xie Y, Yang BB. 2020. Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9. J Ethnopharmacol. 247:1–25. doi:10.1016/j.jep.2019.112256
   Web of Science ®Google Scholar
• Liu X, Xu Y, Li Y, Pan Y, Sun Z, Zhao S, Hou Y. 2020. Ganoderma lucidum fruiting body extracts inhibit colorectal cancer by inducing apoptosis, autophagy, and G0/G1 phase cell cycle arrest in vitro and in vivo. Am J Transl Res. 12:2675–2684. doi:10.2147/CMAR.S221996
   PubMed Web of Science ®Google Scholar
• Mahomoodally MF, Aumeeruddy MZ, Rengasamy KRR, Roshan S, Hammad S, Pandohee J, Hu X, Zengin G. 2021. Ginger and its active compounds in cancer therapy: from folk uses to nano-therapeutic applications. Semin Cancer Biol. 69:140–149. doi:10.1016/j.semcancer.2019.08.009
   PubMed Web of Science ®Google Scholar
• Makaremi S, Ganji A, Ghazavi A, Mosayebi G. 2021. Inhibition of tumor growth in CT-26 colorectal cancer-bearing mice with alcoholic extracts of Curcuma longa and Rosmarinus officinalis. Gene Rep. 22:1–10. doi:10.1016/j.genrep.2020.101006
   Web of Science ®Google Scholar
• Malmir S, Ebrahimi A, Mahjoubi F. 2020. Effect of ginger extracts on colorectal cancer HCT-116 cell line in the expression of MMP-2 and KRAS. Gene Rep. 21:1–8. doi:10.1016/j.genrep.2020.100824
   Web of Science ®Google Scholar
• Mishra J, Drummond J, Quazi SH, Karanki SS, Shaw J, Chen B, Kumar N. 2013. Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis. Crit Rev Oncol Hematol. 86:232–250. doi:10.1016/j.critrevonc.2012.09.014
   PubMed Web of Science ®Google Scholar
• Nedungadi D, Binoy A, Vinod V, Vanuopadath M, Nair SS, Nair BG, Mishra N. 2021. Ginger extract activates caspase independent paraptosis in cancer cells via ER stress, mitochondrial dysfunction, AIF translocation and DNA damage. Nutr Cancer. 73:147–159. doi:10.1080/01635581.2019.1685113
   PubMed Web of Science ®Google Scholar
• Oludemi T, Barros L, Prieto M, Heleno SA, Barreiro MF, Ferreira IC. 2018. Extraction of triterpenoids and phenolic compounds from Ganoderma lucidum: optimization study using the response surface methodology. Food Funct. 9:209–226. doi:10.1039/C7FO01601H
   PubMed Web of Science ®Google Scholar
• Pfaffl MW. 2004. Quantification strategies in real-time PCR. AZ Quant PCR. 1:89–113.
   Google Scholar
• Rios-Fuller TJ, Ortiz-Soto G, Lacourt-Ventura M, Maldonado-Martinez G, Cubano LA, Schneider RJ, Martinez-Montemayor MM. 2018. Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway. Oncotarget. 9:35907–35921. doi:10.18632/oncotarget.26294
   PubMedGoogle Scholar
• Ryu MJ, Chung HS. 2015. [10]-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells. In Vitro Cell Dev Biol Anim. 51:92–101. doi:10.1007/s11626-014-9806-6
   PubMed Web of Science ®Google Scholar
• Saeedifar AM, Mosayebi G, Ghazavi A, Ganji A. 2021. Synergistic evaluation of ginger and licorice extracts in a mouse model of colorectal cancer. Nutr Cancer. 73:1068–1078. doi:10.1080/01635581.2020.1784440
   PubMed Web of Science ®Google Scholar
• Sohretoglu D, Huang S. 2018. Ganoderma lucidum polysaccharides as an anti-cancer agent. Anticancer Agents Med Chem. 18:667–674. doi:10.2174/1871520617666171113121246
   PubMed Web of Science ®Google Scholar
• Song M, Li ZH, Gu HS, Tang RY, Zhang R, Zhu YL, Liu JL, Zhang JJ, Wang LY. 2021. Ganoderma lucidum spore polysaccharide inhibits the growth of hepatocellular carcinoma cells by altering macrophage polarity and induction of apoptosis. J Immunol Res. 2021:1–14. doi:10.1155/2021/6696606
   Web of Science ®Google Scholar
• Srinivasan K. 2017. Ginger rhizomes (Zingiber officinale): a spice with multiple health beneficial potentials. PharmaNutrition. 5:18–28. doi:10.1016/j.phanu.2017.01.001
   Google Scholar
• Su P, Veeraraghavan VP, Krishna Mohan S, Lu W. 2019. A ginger derivative, zingerone—a phenolic compound—induces ROS-mediated apoptosis in colon cancer cells (HCT-116). J Biochem Mol Toxicol. 33:1–8. doi:10.1002/jbt.22403
   Web of Science ®Google Scholar
• Wang Y, Wang S, Song R, Cai J, Xu J, Tang X, Li N. 2019. Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Int J Biol Macromol. 123:81–90. doi:10.1016/j.ijbiomac.2018.10.169
   PubMed Web of Science ®Google Scholar
• Wu X, Jiang L, Zhang Z, He Y, Teng Y, Li J, Yuan S, Pan Y, Liang H, Yang H, Zhou P. 2021. Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum. Oncol Lett. 21:1–11. doi:10.3892/ol.2020.12278
   PubMed Web of Science ®Google Scholar
• Yin SY, Wei WC, Jian FY, Yang NS. 2013. Therapeutic applications of herbal medicines for cancer patients. Evid Based Comple Alt Med. 2013:1–15. doi:10.1155/2013/302426
   Web of Science ®Google Scholar