284
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Incorporating Correlation in Interindividual Variability for the Optimal Design of Multiresponse Pharmacokinetic Experiments

, , &
Pages 342-358 | Received 17 Jan 2007, Accepted 05 Jul 2007, Published online: 18 Mar 2008

REFERENCES

  • al Banna , M. K. , Kelman , A. W. , Whiting , B. ( 1990 ). Experimental design and efficient parameter estimation in population pharmacokinetics . J. Pharmacokinet. Biopharm. 18 : 347 – 360 .
  • Box , M. J. , Draper , N. R. ( 1970 ). Estimation and design for multiresponse nonlinear models, nonhomogenous variance structure . Annals of Mathematical Statistics 41 : 1391 .
  • Draper , N. R. , Hunter , W. G. ( 1966 ). Design of experiments for parameter estimation in multiresponse situations . Biometrika 53 : 525 – 533 .
  • Duffull , S. ( 2006 ). POPT, Optimization for population PKPD study design . http://www.uq.edu.au/pharmacy/sduffull/POPT.htm .
  • Duffull , S. B. , Retout , S. , Mentré , F. ( 2002 ). The use of simulated annealing for finding optimal population designs . Comput. Methods Programs Biomed. 69 : 25 – 35 .
  • Fedorov , V. V. ( 1972 ). Theory of Optimal Experiments . New York : Academic Press .
  • Foracchia , M. , Hooker , A. , Vicini , P. , Ruggeri , A. ( 2004 ). POPED, a software for optimal experiment design in population kinetics . Comput. Methods Programs Biomed. 74 : 29 – 46 .
  • Gagnon , R. , Leonov , S. ( 2005 ). Optimal population designs for PK models with serial sampling . J. Biopharm. Stat. 15 : 143 – 163 .
  • Graham , G. , Aarons , L. ( 2006 ). Optimal blood sampling time windows for parameter estimation in individual and population pharmacokinetic experiments . Stat. Med. 25 : 4004 – 4019 .
  • Gueorgueiva , I. , Aarons , L. , Ogungbenro , K. , Jorga , K. M. , Rodgers , T. , Rowland , M. ( 2006 ). Optimal design for multivariate response pharmacokinetic models . J. Pharmacokinet. Pharmacodyn. 33 : 97 – 124 .
  • Gueorgueiva , I. , Ogungbenro , K. , Graham , G. , Glatt , S. , Aarons , L. ( 2007 ). A program for individual and population optimal design for univariate and multivariate response pharmacokinetic–pharmacodynamic models . Comput. Methods Programs Biomed. Accepted .
  • Holford , N. H. G. , Gobburu , J. V. S. , Mould , D. R. ( 2003 ). Implications of including and excluding correlation of random effects in hierarchical mixed effects pharmacokinetic models . PAGE 12 : abstract 374. http://www.page-meeting.org/default.asp?abstract=374 .
  • Hooker , A. , Vicini , P. ( 2005 ). Simultaneous population optimal design for pharmacokinetic–pharmacodynamic experiments . AAPS Journal 7 : E759 – E785 .
  • Mandema , J. W. , Verotta , D. , Sheiner , L. B. ( 1992 ). Building population pharmacokinetic–pharmacodynamic models. I. Models for covariate effects . J. Pharmacokinet. Biopharm. 20 : 511 – 528 .
  • Mentré , F. , Mallet , A. , Baccar , D. ( 1997 ). Optimal design in random-effects regression models . Biometrika 84 : 429 – 442 .
  • Ogungbenro , K. , Graham , G. , Gueorgueiva , I. , Aarons , L. ( 2005 ). The use of a modified Fedorov exchange algorithm to optimise sampling times for population pharmacokinetic experiments . Comput. Methods Programs Biomed. 80 : 115 – 125 .
  • Ogungbenro , K. , Gueorgueiva , I. , Majid , O. , Graham , G. , Aarons , L. ( 2007 ). Optimal design for multiresponse pharmacokinetic–pharmacodynamic models: Dealing with unbalanced designs . J. Pharmacokinet. Pharmacodyn. 34 : 313 – 331 .
  • Retout , S. , Duffull , S. , Mentré , F. ( 2001 ). Development and implementation of the population Fisher information matrix for the evaluation of population pharmacokinetic designs . Comput. Methods Programs Biomed. 65 : 141 – 151 .
  • Retout , S. , Mentré , F. ( 2003a ). Further developments of the Fisher information matrix in nonlinear mixed effects models with evaluation in population pharmacokinetics . J. Biopharm. Stat. 13 : 209 – 227 .
  • Retout , S. , Mentré , F. (2003b). Optimization of individual and population designs using Splus. J. Pharmacokinet. Pharmacodyn. 30:417–443.
  • Retout , S. , Mentré , F. ( 2005 ). Population design optimisation: PFIMOPT 1.0 . http://www.bichat.inserm.fr/equipes/Emi0357/download.html .
  • Retout , S. , Mentré , F. , Bruno , R. ( 2002 ). Fisher information matrix for non-linear mixed-effects models: Evaluation and application for optimal design of enoxaparin population pharmacokinetics . Stat. Med. 21 : 2623 – 2639 .
  • Schoemaker , N. E. , Mathot , R. A. , Schoffski , P. , Rosing , H. , Schellens , J. H. , Beijnen , J. H. ( 2002 ). Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule . Cancer Chemother. Pharmacol. 50 : 514 – 517 .
  • Waterhouse , T. H. , Redmann , S. , Duffull , S. B. , Eccleston , J. A. ( 2005 ). Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients . J. Pharmacokinet. Pharmacodyn. 32 : 521 – 545 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.