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Letters To The Editor

Response to Letter to the Editor: Statistical Issues of QT Prolongation Assessment Based on Linear Concentration Modeling by Yi Tsong et al.

, , &
Pages 693-697 | Received 22 Apr 2009, Accepted 29 Oct 2009, Published online: 21 Apr 2010

REFERENCES

  • Berger , R. L. ( 1989 ). Uniformly most powerful tests for hypotheses concerning linear inequalities and normal means . J. Am. Stat. Assoc. 84 : 192 – 199 .
  • Boos , D. , Hoffman , D. , Kringle , R. , Zhang , J. ( 2007 ). New confidence bounds for QT studies . Stat. Med. 26 : 3801 – 3817 .
  • Cheng , B. , Chow , S.-C. , Burt , D. , Cosmatos , D. ( 2008 ). Statistical assessment of QT/QTc prolongation based on maximum of correlated normal random variables . J. Biopharm. Stat. 18 ( 3 ): 494 – 501 .
  • Garnett , C. E. , Beasley , N. , Bhattaran , V. A. , Jadhav , P. R. , Madabushi , R. , Stockbridge , N. , Tornee , C. W. , Wang , Y. , Gobburu , J. V. ( 2008 ). Concentration–QT relationships play a key role in the evaluation of proarrhythmic risk during regulatory review . J. Clin. Pharmacol. 48 : 13 – 18 .
  • International Conference on Harmonization. ( 2005 ). ICH (E14) Guidance. The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Nonantiarrhythmic Drugs . International Conference on Harmonization , May , Geneva , Switzerland .
  • Liu , H. , Berger , R. L. ( 1995 ). Uniformly more powerful, one-sided tests for hypotheses about linear inequalities . Ann. Stat. 23 ( 1 ): 55 – 72 .
  • Tsong , Y. , Shen , M. , Zhong , J. , Zhang , J. (2008). Statistical issues of QT prolongation assessment based on linear concentration modeling. J. Biopharm. Stat. 18(3):564–584.
  • Tsong , Y. , Zhang , J. , Zhong , J. ( 2009 ). Letter to the editor: Comment on: New confidence bounds for QT studies, by Dennis D. Boos, David Hoffman, Robert Kringle and Ji Zhang . Stat. Med. 26 : 3801 – 3817 .

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