REFERENCES
- Ahn , J. E. , Karlsson , M. O. , Dunne , A. , Ludden , T. M. ( 2008 ). Likelihood based approaches to handling data below the quantification limit using NONMEM VI . Journal of Pharmacokinetics and Pharmacodynamics 35 : 401 – 421 .
- Beal , S. L. ( 2001 ). Ways to fit a PK model with some data below the quantification limit . Journal of Pharmacokinetics and Pharmacodynamics 28 ( 5 ): 481 – 504 .
- Byon , W. , Fletcher , C. V. , Brundage , R. C. ( 2008 ). Impact of censoring data below an arbitrary quantification limit on structural model misspecification . Journal of Pharmacokinetics and Pharmacodynamics 35 : 101 – 116 .
- Chu , H. , Nie , L. , Kensler , T. ( 2008 ). A Bayesian approach estimating treatment effects on biomarkers containing zeros with detection limits . Statistics in Medicine 27 : 2497 – 2508 .
- Cowles , M. K. , Carlin , B. P. ( 1996 ). Markov chain Monte Carlo convergence diagnosis: A comparative review . Journal of the American Statistical Association 91 : 883 – 904 .
- Duval , V. , Karlsson , M. O. ( 2002 ). Impact of omission or replacement of data below the limit of quantification on parameter estimates in a two-compartment model . Pharmaceutical Research 19 ( 12 ): 1835 – 1840 .
- Gillespie , W. R. , Gastonguay , M. R. , Knebel , W. , Georgalis , G. ( 2008 ). Open source software tools for parallel computation of multiple MCMC chains with WinBUGS. American Conference on Pharmacometrics (ACoP). Available at: http://tucson2008.go-acop.org/abstracts.php
- Hing , J. P. , Woolfrey , S. G. , Greenslade , D. , Wright , P. M. C. (2001). Analysis of toxicokinetic data using NONMEM: Impact of quantification limit and replacement strategies for censored data. Journal of Pharmacokinetics and Pharmacodynamics 28(5):465–479.
- Hughes , J. P. ( 1999 ). Mixed effects models with censored data with application to HIV RNA levels . Biometrics 55 : 625 – 629 .
- Jacqmin-Gadda , H. , Thiébaut , R. ( 2000 ). Analysis of left-censored longitudinal data with application to viral load in HIV infection . Biostatistics 1 ( 4 ): 355 – 368 .
- Klein , J. P. , Moeschberger , M. L. ( 2003 ). Survival Analysis: Techniques for Censored and Truncated Data. , 2nd ed. New York : Springer .
- Lindsey , J. K. , Byrom , W. D. , Wang , J. , Jarvis , P. , Jones , B. ( 2000 ). Generalized nonlinear models for Pharmacokinetic data . Biometrics 56 : 81 – 88 .
- Lunn , D. J. , Best , N. , Thomas , A. , Wakefield , J. , Spiegelhalter , D. ( 2002 ). Bayesian analysis of population PK/PD models: General concepts and software . Journal of Pharmacokinetics and Pharmacodynamics 29 ( 3 ): 271 – 307 .
- Lunn , D. J. , Thomas , A. , Best , N. , Spiegelhalter , D. ( 2000 ). WinBUGS—A Bayesian modelling framework: concepts, structure, and extensibility . Statistics and Computing 10 : 325 – 337 .
- Lynn , H. S. ( 2001 ). Maximum likelihood inference for left-censored HIV RNA data . Statistics in Medicine 20 : 33 – 45 .
- Rahman , N. J. , Wakefield , J. C. , Stephens , D. A. , Falcoz , C. ( 1999 ). The Bayesian analysis of a pivotal pharmacokinetic study . Statistical Methods in Medical Research 8 : 195 – 216 .
- Thiébaut , R. , Jacqmin-Gadda , H. , Badiker , A. , Commenges , D. ( 2005 ). Joint modeling of bivariate longitudinal data with informative dropout and left-censoring, with application to the evolution of CD4+ cell count and HIV RNA viral load in response to treatment of HIV infection . Statistics in Medicine 24 : 65 – 82 .
- Wakefield , J. , Racine-Poon , A. ( 1995 ). An application of Bayesian population pharmacokinetic/pharmacodynamic models to dose recommendation . Statistics in Medicine 14 : 971 – 986 .