REFERENCES
- Eisenberg , D M , Davis , R B , Ettner , S L , Appel , S , Wilkey , S , Van Rompay , M and Kessler , R C . 1998 . Trends in alternative medicine use in the United States, 1990–1997: Results of a follow-up national survey . Journal of the American Medical Association , 280 : 1569 – 1575 . [PUBMED] [INFOTRIEVE] [CSA]
- Tindle , H A , Davis , R B , Phillips , R S and Eisenberg , D M . 2005 . Trends in use of complementary and alternative medicine by US adults: 1997–2002 . Altern Ther Health Med , 11 : 42 – 49 . [INFOTRIEVE] [CSA]
- Kaye , A D , Clarke , R C , Sabar , R , Vig , S , Dhawan , K P , Hofbauer , R and Kaye , A M . 2000 . Herbal medicines: current trends in anesthesiology practice—a hospital survey . J Clin Anesth , 12 : 468 – 471 . [INFOTRIEVE] [CSA] [CROSSREF]
- Cohen , S M , Rousseau , M E and Robinson , E H . 2000 . Therapeutic use of selected herbs . Holistic Nursing Practice , 14 : 59 – 68 . [INFOTRIEVE] [CSA]
- Angell , M and Kassirer , J P . 1998 . Alternative medicine–the risks of untested and unregulated remedies . N Engl J Med , 339 : 839 – 841 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
- Davis , R H , Donato , J J , Hartman , G M and Haas , R C . 1994 . Anti-inflammatory and wound healing activity of a growth substance in Aloe vera . J Am Podiatr Med Assoc , 84 : 77 – 81 . [INFOTRIEVE] [CSA]
- Visuthikosol , V , Chowchuen , B , Sukwanarat , Y , Sriurairatana , S and Boonpucknavig , V . 1995 . Effect of aloe vera gel to healing of burn wound a clinical and histologic study . J Med Assoc Thai , 78 : 403 – 409 . [INFOTRIEVE] [CSA]
- Klepser , T B , Doucette , W R , Horton , M R , Buys , L M , Ernst , M E , Ford , J K , Hoehns , J D , Kautzman , H A , Logemann , C D , Swegle , J M , Ritho , M and Klepser , M E . 2000 . Assessment of patients' perceptions and beliefs regarding herbal therapies . Pharmacotherapy , 20 : 83 – 87 . [INFOTRIEVE] [CSA] [CROSSREF]
- Vogelzang , J L . 2001 . What you need to know about dietary supplements . Home Healthcare Nurse , 19 : 50 – 52 . [INFOTRIEVE] [CSA] [CROSSREF]
- Grindlay , D and Reynolds , T . 1986 . The Aloe vera phenomenon: A review of the properties and modern uses of the leaf parenchyma gel . J Ethnopharmacol , 16 : 117 – 151 . [INFOTRIEVE] [CSA] [CROSSREF]
- Lee , K Y , Weintraub , S T and Yu , B P . 2000 . Isolation and identification of a phenolic antioxidant from Aloe barbadensis . Free Radical Biology and Medicine , 28 : 261 – 265 . [INFOTRIEVE] [CSA] [CROSSREF]
- Reynolds , T and Dweck , A C . 1999 . Aloe vera leaf gel: A review update . J Ethnopharmacol , 68 : 3 – 37 . [INFOTRIEVE] [CSA] [CROSSREF]
- Briggs , C . 1995 . Herbal medicine: aloe . Canadian Pharmaceutical Journal , 128 : 48 – 50 . [CSA]
- Gallagher , J and Gray , M . 2003 . Is aloe vera effective for healing chronic wounds? . J Wound Ostomy Continence Nurs , 30 : 68 – 71 . [INFOTRIEVE] [CSA]
- Miller , M B and Koltai , P J . 1995 . Treatment of experimental frostbite with pentoxifylline and Aloe vera cream . Arch Otolarnyngol Head Neck Surg , 121 : 678 – 680 . [CSA]
- Somboonwong , J , Thanamittramanee , S , Jariyapongskul , A and Patumraj , S . 2000 . Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats . J Med Assoc Thai , 83 : 417 – 425 . [INFOTRIEVE] [CSA]
- Kaufman , T , Kalderon , N , Ullmann , Y and Berger , J . 1988 . Aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled study . J Burn Care Rehabil , 9 : 156 – 159 . [INFOTRIEVE] [CSA]
- Fisher , J , Scott , C , Stevens , R , Marconi , B , Champion , L , Freedman , G M , Asrari , F , Pilepich , M V , Gagnon , J D and Wong , G . 2000 . Randomized phase III study comparing best supportive care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13 . Int J Radiat Oncol Biol Phys , 48 : 1307 – 1310 . [INFOTRIEVE] [CSA] [CROSSREF]
- Thomas , D R , Goode , P S , LaMaster , K and Tennyson , T . 1998 . Acemannan hydrogel dressing versus saline dressing for pressure ulcers. A randomized, controlled trial . Adv Wound Care , 11 : 273 – 276 . [INFOTRIEVE] [CSA]
- Seyger , M M , van de Kerkhof , P C , van Vlijmen-Willems , I M , de Bakker , E S , Zwiers , F and de Jong , E M . 1998 . The efficacy of a new topical treatment for psoriasis: Mirak . J Eur Acad Dermatol Venereol , 11 : 13 – 18 . [INFOTRIEVE] [CSA] [CROSSREF]
- Chithra , P , Sajithlal , G B and Chandrakasan , G . 1998 . Influence of aloe vera on the healing of dermal wounds in diabetic rats . J Ethnopharmacol , 59 : 195 – 201 . [INFOTRIEVE] [CSA] [CROSSREF]
- Chithra , P , Sajithlal , G B and Chandrakasan , G . 1998 . Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats . J Ethnopharmacol , 59 : 179 – 186 . [INFOTRIEVE] [CSA] [CROSSREF]
- Davis , R H , Leitner , M G and Russo , J M . 1988 . Aloe vera. A natural approach for treating wounds, edema, and pain in diabetes . J Am Podiatr Med Assoc , 78 : 60 – 68 . [INFOTRIEVE] [CSA]
- Davis , R H , Kabbani , J M and Maro , N P . 1987 . Aloe vera and wound healing . J Am Podiatr Med Assoc , 77 : 165 – 169 . [INFOTRIEVE] [CSA]
- Muller , M J , Hollyoak , M A , Moaveni , Z , Brown , T L , Herndon , D N and Heggers , J P . 2003 . Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin . Burns , 29 : 834 – 836 . [INFOTRIEVE] [CSA] [CROSSREF]
- Roesler , J , Steinmuller , C , Kiderlen , A , Emmendorffer , A , Wagner , H and Lohmann-Matthes , M L . 1991 . Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to mice mediates protection against systemic infections with Listeria monocytogenes and Candida albicans . Int J Immunopharmacol , 13 : 27 – 37 . [INFOTRIEVE] [CSA] [CROSSREF]
- Ernst , E . 2000 . Adverse effects of herbal drugs in dermatology . Br J Dermatol , 143 : 923 – 929 . [INFOTRIEVE] [CSA] [CROSSREF]
- 2005 . Vol. 2005 , Nantwich, Cheshire, , UK : JoJaffa Limited . Aloe Vera Healer Web site. http://www.aloeandwellness.co.uk
- 2003 . Vol. 2005 , Miracle o f Aloe Web site: http://www.miracleofaloe.com
- 2005 . Vol. 2005 , Forever Living Web site: http://www.foreverliving.com
- Marshall , J M . 1990 . Aloe vera gel: what is the evidence? . Pharm J , 244 : 360 – 362 . [CSA]
- Imanishi , K and Suzuki , I . 1984 . Augmentation of natural cell-mediated cytotoxic reactivity of mouse lymphoid cells by aloctin A . Int J Immunopharmacol , 6 : 539 – 543 . [INFOTRIEVE] [CSA] [CROSSREF]
- Imanishi , K and Suzuki , I . 1986 . Induction of nonspecific cell-mediated cytotoxic reactivity from non-immune spleen cells treated with aloctin A . Int J Immunopharmacol , 8 : 781 – 787 . [INFOTRIEVE] [CSA] [CROSSREF]
- Imanishi , K , Tsukuda , K and Suzuki , I . 1986 . Augmentation of lymphokine-activated killer cell activity in vitro by aloctin A . Int J Immunopharmacol , 8 : 855 – 858 . [INFOTRIEVE] [CSA] [CROSSREF]
- Keum , Y S , Park , K K , Lee , J M , Chun , K S , Park , J H , Lee , S K , Kwon , H and Surh , Y J . 2000 . Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng . Cancer Lett , 150 : 41 – 48 . [INFOTRIEVE] [CSA] [CROSSREF]
- Kim , H S , Kacew , S and Lee , B M . 1999 . In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor) . Carcinogenesis , 20 : 1637 – 1640 . [INFOTRIEVE] [CSA] [CROSSREF]
- Zhao , J , Wang , J , Chen , Y and Agarwal , R . 1999 . Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3′-gallate as the most effective antioxidant constituent . Carcinogenesis , 20 : 1737 – 1745 . [INFOTRIEVE] [CSA] [CROSSREF]
- Imanishi , K , Ishiguro , T , Saito , H and Suzuki , I . 1981 . Pharmacological studies on a plant lectin, Aloctin A. I. Growth inhibition of mouse methylcholanthrene-induced fibrosarcoma (Meth A) in ascites form by Aloctin A . Experientia , 37 : 1186 – 1187 . [INFOTRIEVE] [CSA] [CROSSREF]
- Hanley , D C , Solomon , W A , Saffran , B and Davis , R H . 1982 . The evaluation of natural substances in the treatment of adjuvant arthritis . J Am Podiatry Assoc , 72 : 275 – 284 . [INFOTRIEVE] [CSA]
- Davis , R H , Agnew , P S and Shapiro , E . 1986 . Antiarthritic activity of anthraquinones found in aloe for podiatric medicine . J Am Podiatr Med Assoc , 76 : 61 – 66 . [INFOTRIEVE] [CSA]
- Spoerke , D G and Ekins , B R . 1980 . Aloe vera—fact or quackery . Vet Hum Toxicol , 22 : 418 – 424 . [INFOTRIEVE] [CSA]
- Davis , R H , Stewart , G J and Bregman , P J . 1992 . Aloe vera and the inflamed synovial pouch model . J Am Podiatr Med Assoc , 82 : 140 – 148 . [INFOTRIEVE] [CSA]
- Dykman , K D , Tone , C , Ford , C and Dykman , R A . 1998 . The effects of nutritional supplements on the symptoms of fibromyalgia and chronic fatigue syndrome . Integr Physiol Behav Sci , 33 : 61 – 71 . [INFOTRIEVE] [CSA]
- Pecere , T , Gazzola , M V , Mucignat , C , Parolin , C , Vecchia , F D , Cavaggioni , A , Basso , G , Diaspro , A , Salvato , B , Carli , M and Palu , G . 2000 . Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors . Cancer Res , 60 : 2800 – 2804 . [INFOTRIEVE] [CSA]
- Ajabnoor , M A . 1990 . Effect of aloes on blood glucose levels in normal and alloxan diabetic mice . J Ethnopharmacol , 28 : 215 – 220 . [INFOTRIEVE] [CSA] [CROSSREF]
- Bunyapraphatsara , N , Yongchaiyudha , S , Rungpitarangsi , V and Chokechaijaroenporn , O . 1996 . Antidiabetic activity of Aloe vera L. juice. II. Clinical trail in diabetes mellitus patients in combination with glibenclamide . Phytomedicine , 3 : 245 – 248 . [CSA]
- Ghannam , N , Kingston , M , Al-Meshaal , I A , Tariq , M , Parman , N S and Woodhouse , N . 1986 . The antidiabetic activity of aloes: preliminary clinical and experimental observations . Horm Res , 24 : 288 – 294 . [INFOTRIEVE] [CSA]
- Roman-Ramos , R , Flores-Saenz , J L , Partida-Hernandez , G , Lara-Lemus , A and Alarcon-Aguilar , F . 1991 . Experimental study of the hypoglycemic effect of some antidiabetic plants . Arch Invest Med (Mex) , 22 : 87 – 93 . [CSA]
- Yongchaiyudha , S , Rungpitarangsi , V , Bunyapraphatsara , N and Chokechaijaroenporn , O . 1996 . Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus . Phytomedicine , 3 : 241 – 243 . [CSA]
- Saito , H , Imanishi , K and Okabe , S . 1989 . Effects of aloe extracts, aloctin A, on gastric secretion and on experimental gastric lesions in rats . Yakugaku Zasshi , 109 : 335 – 339 . [INFOTRIEVE] [CSA]
- Atherton , P . 1998 . Aloe vera: magic or medicine? . Nurs Stand , 12 : 49 – 54 . [INFOTRIEVE] [CSA]
- Teradaira , R , Shinzato , M , Beppu , H and Fujita , H . 1993 . Antigastric ulcer effects in rats of Aloe arborescens Miller var. natalensis berger extract . Phytother Res , 7 : S34 – S36 . [CSA]
- Hutter , J A , Salman , M , Stavinoha , W B , Satsangi , N , Williams , R F , Streeper , R T and Weintraub , S T . 1996 . Antiinflammatory C-glucosyl chromone from Aloe barbadensis . J Nat Prod , 59 : 541 – 543 . [INFOTRIEVE] [CSA] [CROSSREF]
- Davis , R H , Leitner , M G and Russo , J M . 1987 . Topical anti-inflammatory activity of Aloe vera as measured by ear swelling . J Am Podiatr Med Assoc , 77 : 610 – 612 . [INFOTRIEVE] [CSA]
- Hecht , A . 1981 . The overselling of aloe vera . FDA Consumer , 15 : 27 – 29 . [CSA]
- Klein , A D and Penneys , N S . 1988 . Aloe vera . J Am Acad Dermatol , 18 : 714 – 720 . [INFOTRIEVE] [CSA]
- Femenia , A , Sanchez , E S , Simal , S and Rossello , C . 1999 . Compositional features of polysacchardies from Aloe vera (Aloe barbadensis Miller) plant tissues . Carbohydrate Polymers , 39 : 109 – 117 . [CSA] [CROSSREF]
- Turner , C E , Williamson , D A , Stroud , P A and Talley , D J . 2004 . Evaluation and comparison of commercially available Aloe vera L. products using size exclusion chromatography with refractive index and multi-angle laser light scattering detection . Int Immunopharmacol , 4 : 1727 – 1737 . [INFOTRIEVE] [CSA] [CROSSREF]
- Paez , A , Gebre , G M , Gonzalez , M E and Tschaplinski , T J . 2000 . Growth, soluble carbohydrates, and aloin concentration of Aloe vera plants exposed to three irradiance levels . Environmental and Experimental Botany , 44 : 133 – 139 . [INFOTRIEVE] [CSA] [CROSSREF]
- Bouthet , C F , Schirf , V R and Winters , W D . 1995 . Stimulation of neuron-like cell growth by aloe substances . Phytother Res , 9 : 185 – 188 . [CSA]
- Yagi , A , Egusa , T , Arase , M , Tanabe , M and Tsuji , H . 1997 . Isolation and characterization of the glycoprotein fraction with a proliferation-promoting activity on human and hamster cells in vitro from Aloe vera gel . Planta Med , 63 : 18 – 21 . [INFOTRIEVE] [CSA]
- Viljoen , A M and van Wyk , B E . 2000 . The chemotaxonomic significance of the phenyl pyrone aloenin in the genus Aloe . Biochem Syst Ecol , 28 : 1009 – 1017 . [INFOTRIEVE] [CSA] [CROSSREF]
- Eshun , K and He , Q . 2004 . Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries—a review . Crit Rev Food Sci Nutr , 44 : 91 – 96 . [INFOTRIEVE] [CSA] [CROSSREF]
- Takahashi , M , Konaka , D , Sakamoto , A and Morikawa , H . 2005 . Nocturnal uptake and assimilation of nitrogen dioxide by C3 and CAM plants . Z Naturforsch [C] , 60 : 279 – 284 . [CSA]
- Ni , Y , Turner , D , Yates , K M and Tizard , I . 2004 . Isolation and characterization of structural components of Aloe vera L. leaf pulp . Int Immunopharmacol , 4 : 1745 – 1755 . [INFOTRIEVE] [CSA] [CROSSREF]
- Saccu , D , Bogoni , P and Procida , G . 2001 . Aloe exudate: characterization by reversed phase HPLC and headspace GC-MS . J Agric Food Chem , 49 : 4526 – 4530 . [INFOTRIEVE] [CSA] [CROSSREF]
- Yaron , A . 1993 . Characterization of Aloe vera gel before and after autodegradation, and stabilization of the natural fresh gel . Phytother Res , 7 : 11 – 13 . [CSA]
- Shelton , R M . 1991 . Aloe vera. Its chemical and therapeutic properties . Int J Dermatol , 30 : 679 – 683 . [PUBMED] [INFOTRIEVE] [CSA]
- Wang , Y T and Strong , K J . 1995 . Two-year study monitoring several physical and chemical properties of field-grown Aloe barbadensis Miller leaves . Subtropical Plant Science , 47 : 34 – 38 . [CSA]
- Genet , W BM and van Schooten , C AM . 1992 . Water requirements of Aloe vera in a dry Carribean climate . Irrig Sci , 13 : 81 – 85 . [CSA] [CROSSREF]
- Waller , T A , Pelley , R P and Strickland , F M . 2004 . “ Industrial processing and quality control of Aloe barbadensis ” . In Aloes: The Genus Aloes , Edited by: Reynolds , T. Vol. 38 , 139 – 205 . Boca Raton, Florida : CRC Press .
- Robson , M C , Heggers , J P and Hagstrom , W J . 1982 . Myth, magic, witchcraft or fact? Aloe vera revsited . J Burn Care Rehabil , 3 : 157 – 162 . [CSA]
- Danhof , I E . 1998 . Position statement on polysaccharides http://www.gothica.com
- Gowda , D C , Neelisiddaiah , B and Anjaneyalu , Y V . 1979 . Structural studies of polysaccharides from Aloe vera . Carbohydrate Research , 72 : 201 – 205 . [CSA] [CROSSREF]
- Chow , J T-N. , Williamson , D A , Yates , K M and Goux , W J . 2005 . Chemical characterization of the immunomodulating polysaccharide of Aloe vera L . Carbohydrate Research , 340 : 1131 – 1142 . [CSA] [CROSSREF]
- Mandal , G and Das , A . 1980 . Structure of the glucomannan isolated from the leaves of Aloe barbadensis Miller . Carbohydrate Research , 87 : 249 – 256 . [CSA] [CROSSREF]
- Green , P . 1996 . Aloe vera extracts in equine clinical practice . Veterinary Times , 26 : 16 – 18 . [CSA]
- Sheets , M A , Unger , B A , Giggleman , G F Jr. and Tizard , I R . 1991 . Studies of the effect of acemannan on retrovirus infections: clinical stabilization of feline leukemia virus-infected cats . Mol Biother , 3 : 41 – 45 . [INFOTRIEVE] [CSA]
- Gorloff , D R . 1983 . Study of the organoleptic properties of the exuded mucilage from aloe barbadensis leaves . Erde International , 1 : 46 – 59 . [CSA]
- Ross , S A , El Sohly , M A and Wilkins , S P . 1997 . Quantitative analysis of Aloe vera mucilaginous polysaccharide in commercial Aloe vera products . J AOAC International , 80 : 455 – 457 . [CSA]
- Mandal , G and Das , A . 1980 . Structure of the D-galactan isolated from Aloe barbadensis Miller . Carbohydrate Research , 86 : 247 – 257 . [CSA] [CROSSREF]
- Wink , M . 2003 . Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective . Phytochemistry , 64 : 3 – 19 . [INFOTRIEVE] [CSA] [CROSSREF]
- Chauser-Volfson , E and Gutterman , Y . 1996 . The barbaloin content and distribution in Aloe arborescens leaves according to leaf part, age, position and season . Isr. J. Plant Sci , 44 : 289 – 296 . [CSA]
- Gutterman , Y and Chauser-Volfson , E . 2000 . Peripheral defense strategy: variation of barbaloin content in the succulen leaf parts of Aloe arborescens Miller (liliacae) . Bontanical Journal of the Linnean Society , 132 : 385 – 395 . [CSA] [CROSSREF]
- Gutterman , Y and Chauser-Volfson , E . 2000 . The distribution of the phenolic metabolites barbaloin, aloeresin and aloenin as a peripheral defense strategy in the succulent leaf parts of Aloe arborescens . Biochemical Systematics and Ecology , 28 : 825 – 838 . [INFOTRIEVE] [CSA] [CROSSREF]
- Reynolds , T . 1985 . Observations on the phytochemistry of the Aloe leaf-exudate compounds . Botanical Journal of the Linnean Society , 90 : 179 – 199 . [CSA]
- Park , M K , Park , J H , Kim , N Y , Shin , Y G , Choi , Y S , Lee , J G , Kim , K H and Lee , S K . 1998 . Analysis of 13 phenolic compounds in Aloe species by high performance liquid chromatography . Phytochemical analysis , 9 : 186 – 191 . [CSA] [CROSSREF]
- Smith , T and Smith , H . 1851 . On aloin: the cathartic principles of aloes . Monthly Journal of Medical Science , 12 : 127 – 131 . [CSA]
- Birch , A J and Donovan , F W . 1955 . Barbaloin. I. Some observations on its structure . Australian Journal of Chemistry , 8 : 523 – 528 . [CSA]
- Reynolds , T . 1985 . The compounds in Aloe leaf exudates: a review . Botanical Journal of the Linnean society , 90 : 157 – 177 . [CSA]
- Hay , J E and Haynes , L J . 1956 . The aloins. Part I. The structure of barbaloin . J Chem Soc , : 3141 – 3147 . [CSA] [CROSSREF]
- Joshi , S P . 1998 . Chemical constituents and biological activity of Aloe barbadensis-a review . Journal of Medicinal and Aromatic Plant Sciences , 20 : 768 – 773 . [CSA]
- Vyth , A and Kamp , P E . 1979 . Detection of anthraquinone laxatives in the urine . Pharm Weekbl , 114 : 456 – 459 . [CSA]
- Che , Q M , Akao , T , Hattori , M , Kobashi , K and Namba , T . 1991 . Isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone . Planta Med , 57 : 15 – 19 . [INFOTRIEVE] [CSA]
- Hattori , M , Kanda , T , Shu , Y Z , Akao , T , Kobashi , K and Namba , T . 1988 . Metabolism of barbaloin by intestinal bacteria . Chem Pharm Bull (Tokyo) , 36 : 4462 – 4466 . [CSA]
- Mapp , R K and McCarthy , T J . 1970 . The assessment of purgative principles in aloes . Plant Medicine , 18 : 361 – 365 . [CSA]
- Franz , G and Grun , M . 1983 . Chemistry, occurence and biosynthesis of C-glycosyl compounds in plants . Planta Med , 47 : 131 – 140 . [CSA]
- Groom , Q J and Reynolds , T . 1986 . Barbaloin in Aloe species . Planta Med , 52 : 345 – 348 . [CSA]
- Viljoen , A M , van Wyk , B -E and Newton , L E . 2001 . The occurrence and taxonomic distribution of the anthrones aloin, aloinoside and microdontin in Aloe . Biochem Syst Ecol , 29 : 53 – 67 . [INFOTRIEVE] [CSA] [CROSSREF]
- Brusick , D and Mengs , U . 1997 . Assessment of the genotoxic risk from laxative senna products . Environ Mol Mutagen , 29 : 1 – 9 . [INFOTRIEVE] [CSA] [CROSSREF]
- Saleem , R , Faizi , S , Deeba , F , Siddiqui , B S and Qazi , M H . 1997 . Anthrones from Aloe barbadensis . Phytochemistry , 45 : 1279 – 1282 . [CSA] [CROSSREF]
- Mannitto , P , Monti , D and Speranza , G . 1990 . Studies on aloe. Part 6. Conformation and absolute configuration of aloins A and B and related 10-C-glucosyl-9-anthrones . Journal of the Chemical Society Perkin I , 5 : 1297 – 1300 . [CSA] [CROSSREF]
- Haynes , L J , Holdsworth , D K and Russel , R . 1970 . C-glycosyl compounds. Part V I Aloesin, a C-glucosylchromone from Aloe sp . Journal of the Chemical Society (C) , 18 : 2581 – 2586 . [CSA]
- Gramatica , P , Monti , D , Speranza , G and Manitto , P . 1982 . Aloe revisited—the structure of aloresin A . Tetrahedron Letters , 23 : 2423 – 2424 . [CSA] [CROSSREF]
- Okamura , H , Hine , N , Harada , S , Fujioka , T , Mihashi , K , Nishi , M , Miyahara , K and Yagi , A . 1997 . Diastereomic C-glycosylanthrones of Aloe vera leaves . Phytochemistry , 45 : 1519 – 1522 . [CSA] [CROSSREF]
- Okamura , N , Asaia , M , Hinea , N and Yagi , A . 1996 . High-performance liquid chromatographic determination of phenolic compounds in Aloe species . J Chromatogr A , 746 : 225 – 231 . [CSA] [CROSSREF]
- Zonta , F , Bogoni , P , Masotti , P and Micali , G . 1995 . High-performance liquid chromatographic profiles of aloe constituents and determination of aloin in beverages, with reference to the EEC regulation for flavouring substances . J Chromatogr A , 718 : 99 – 106 . [INFOTRIEVE] [CSA]
- Yagi , A , Nakamori , J , Yamada , T , Iwase , H , Tanaka , T , Kaneo , Y , Qiu , J and Orndorff , S . 1999 . In vivo metabolism of aloemannan . Planta Med , 65 : 417 – 420 . [INFOTRIEVE] [CSA]
- Rajasekaran , S , Sivagnanam , K , Ravi , K and Subramanian , S . 2004 . Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats . J Med Food , 7 : 61 – 66 . [INFOTRIEVE] [CSA] [CROSSREF]
- Al-Awadi , F , Fatania , H and Shamte , U . 1991 . The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats . Diabetes Res , 18 : 163 – 168 . [INFOTRIEVE] [CSA]
- Parihar , M S , Chaudhary , M , Shetty , R and Hemnani , T . 2004 . Susceptibility of hippocampus and cerebral cortex to oxidative damage in streptozotocin treated mice: prevention by extracts of Withania somnifera and Aloe vera . J Clin Neurosci , 11 : 397 – 402 . [INFOTRIEVE] [CSA] [CROSSREF]
- Bolkent , S , Akev , N , Ozsoy , N , Sengezer-Inceli , M , Can , A , Okyar , A and Yanardag , R . 2004 . Effect of Aloe vera (L.) Burm. fil. leaf gel and pulp extracts on kidney in type-II diabetic rat models . Indian Journal of Experimental Biology , 42 : 48 – 52 . [INFOTRIEVE] [CSA]
- Can , A , Akev , N , Ozsoy , N , Bolkent , S , Arda , B P , Yanardag , R and Okyar , A . 2004 . Effect of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models . Biol Pharm Bull , 27 : 694 – 698 . [INFOTRIEVE] [CSA] [CROSSREF]
- Nasiff , H A , Fajardo , F R and Velez , F MEdP . 1993 . Efecto del aloe sobre la hiperlipidemia en pacientes refractarios a la dieta . Revista Cubana de Med Gen Integral , 9 : 43 – 51 . [CSA]
- Agarwal , O P . 1985 . Prevention of atheromatous heart disease . Angiology , 36 : 485 – 492 . [INFOTRIEVE] [CSA]
- Danhof , I E and McAnally , B H . 1983 . Stabilized aloe vera: Effect on human skin cells . Drug Cosmet Ind , 133 : 52 – 54 . 101–102[CSA]
- Hayes , S M . 1999 . Lichen planus—report of successful treatment with Aloe vera . Gen Dent , 47 : 268 – 272 . [INFOTRIEVE] [CSA]
- Winters , W D , Benavides , R and Clouse , W J . 1981 . Effects of Aloe extracts on human normal and tumor cells in vitro . Economic Botany , 35 : 89 – 95 . [CSA]
- Bowles , W B . 1994 . Aloe vera gel and its effect on cell growth . Parfumerie und Kosmetik , 75 : 660 – 661 . [CSA]
- Akev , N and Can , A . 1999 . Separation and some properties of Aloe vera L. leaf pulp lectins . Phytother Res , 13 : 489 – 493 . [INFOTRIEVE] [CSA] [CROSSREF]
- Choi , S W , Son , B W , Son , Y S , Park , Y I , Lee , S K and Chung , M H . 2001 . The wound-healing effect of a glycoprotein fraction isolated from Aloe vera . Br J Dermatol , 145 : 535 – 545 . [INFOTRIEVE] [CSA] [CROSSREF]
- Mantle , D , Gok , M A and Lennard , T W . 2001 . Adverse and beneficial effects of plant extracts on skin and skin disorders . Adverse Drug React Toxicol Rev , 20 : 89 – 103 . [INFOTRIEVE] [CSA]
- Rodriguez-Bigas , M , Cruz , N I and Suarez , A . 1988 . Comparative evaluation of aloe vera in the management of burn wounds in guinea pigs . Plast Reconstr Surg , 81 : 386 – 389 . [INFOTRIEVE] [CSA]
- Watcher , M A and Wheeland , R G . 1989 . The role of topical agents in the healing of full-thickness wounds . J Dermatol Surg Oncol , 15 : 1188 – 1195 . [INFOTRIEVE] [CSA]
- Heggers , J P , Kucukcelebi , A , Stabenau , C J , Ko , F , Broemeling , L D and Robson , M C . 1995 . Wound healing effects of Aloe gel and other topical antibacterial agents on rat skin . Phytother Res , 9 : 455 – 457 . [CSA]
- Heggers , J P , Kucukcelebi , A , Listengarten , D , Stabenau , J , Ko , F , Broemeling , L D , Robson , M C and Winters , W D . 1996 . Beneficial effect of Aloe on wound healing in an excisional wound model . The Journal of Alternative and Complementary Medicine , 2 : 217 – 277 . [CSA]
- Fulton , J E Jr . 1990 . The stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing . J Dermatol Surg Oncol , 16 : 460 – 467 . [INFOTRIEVE] [CSA]
- Schmidt , J M and Greenspoon , J S . 1991 . Aloe vera dermal wound gel is associated with a delay in wound healing . Obstet Gynecol , 78 : 115 – 117 . [INFOTRIEVE] [CSA]
- Williams , M S , Burk , M , Loprinzi , C L , Hill , M , Schomberg , P J , Nearhood , K , O'Fallon , J R , Laurie , J A , Shanahan , T G , Moore , R L , Urias , R E , Kuske , R R , Engel , R E and Eggleston , W D . 1996 . Phase I II double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity . Int J Radiat Oncol Biol Phys , 36 : 345 – 349 . [INFOTRIEVE] [CSA] [CROSSREF]
- Heggie , S , Bryant , G P , Tripcony , L , Keller , J , Rose , P , Glendenning , M and Heath , J . 2002 . A Phase I II study on the efficacy of topical Aloe vera gel on irradiated breast tissue . Cancer Nurs , 25 : 442 – 451 . [INFOTRIEVE] [CSA] [CROSSREF]
- Olsen , D L , Raub , W Jr , Bradley , C , Johnson , M , Macias , J L , Love , V and Markoe , A . 2001 . The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy . Oncol Nurs Forum , 28 : 543 – 547 . [INFOTRIEVE] [CSA]
- Paulsen , E , Korsholm , L and Brandrup , F . 2005 . A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris . J Eur Acad Dermatol Venereol , 19 : 326 – 331 . [INFOTRIEVE] [CSA] [CROSSREF]
- Syed , T A , Ahmad , S A , Holt , A H , Ahmad , S A , Ahmad , S H and Afzal , M . 1996 . Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study . Trop Med Int Health , 1 : 505 – 509 . [INFOTRIEVE] [CSA] [CROSSREF]
- Davis , R H , Leitner , M G , Russo , J M and Byrne , M E . 1989 . Wound healing. Oral and topical activity of Aloe vera . J Am Podiatr Med Assoc , 79 : 559 – 562 . [INFOTRIEVE] [CSA]
- Breier , G and Risau , W . 1996 . The role of vascular endothelial growth factor in blood vessel formation . Trends Cell Biol , 6 : 454 – 456 . [INFOTRIEVE] [CSA] [CROSSREF]
- Bischoff , J . 1995 . Approaches to studying cell adhesion molecules in angiogenesis . Trends Cell Biol , 5 : 69 – 74 . [INFOTRIEVE] [CSA] [CROSSREF]
- Folkman , J and Klagsbrun , M . 1987 . Angiogenic factors . Science , 235 : 442 – 447 . [INFOTRIEVE] [CSA]
- Moon , E J , Lee , Y M , Lee , O H , Lee , M J , Lee , S K , Chung , M H , Park , Y I , Sung , C K , Choi , J S and Kim , K W . 1999 . A novel angiogenic factor derived from Aloe vera gel: beta-sitosterol, a plant sterol . Angiogenesis , 3 : 117 – 123 . [INFOTRIEVE] [CSA] [CROSSREF]
- Lee , M J , Lee , O H , Yoon , S H , Lee , S K , Chung , M H , Park , Y I , Sung , C K , Choi , J S and Kim , K W . 1998 . In vitro angiogenic activity of Aloe vera gel on calf pulmonary artery endothelial (CPAE) cells . Arch Pharm Res , 21 : 260 – 265 . [INFOTRIEVE] [CSA] [CROSSREF]
- Choi , S , Kim , K -W , Choi , J -S , Han , S -T , Park , Y -I , Lee , S -K , Kim , J -S and Chung , M -C . 2002 . Angiogenic activity of beta-sitosterol in the ischaemia/reperfusion-damaged brain of Mongolian gerbil . Planta Med , 68 : 330 – 335 . [INFOTRIEVE] [CSA] [CROSSREF]
- Pugh , N , Ross , S A , ElSohly , M A and Pasco , D S . 2001 . Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity . J Agric Food Chem , 49 : 1030 – 1034 . [INFOTRIEVE] [CSA] [CROSSREF]
- Qiu , Z , Jones , K , Wylie , M , Jia , Q and Orndorff , S . 2000 . Modified Aloe barbadensis polysaccharide with immunoregulatory activity . Planta Med , 66 : 152 – 156 . [INFOTRIEVE] [CSA] [CROSSREF]
- Im , S -A , Oh , S -T , Song , S , Kim , M -R , Kim , D -S , Woo , S -S , Jo , T H , Park , Y I and Lee , C -K . 2005 . Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity . International Immunopharmacology , 5 : 271 – 279 . [INFOTRIEVE] [CSA] [CROSSREF]
- Talmadge , J , Chavez , J , Jacobs , L , Munger , C , Chinnah , T , Chow , J T , Williamson , D and Yates , K . 2004 . Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activity . Int Immunopharmacol , 4 : 1757 – 1773 . [INFOTRIEVE] [CSA] [CROSSREF]
- Zhang , L and Tizard , I R . 1996 . Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel . Immunopharmacology , 35 : 119 – 128 . [INFOTRIEVE] [CSA] [CROSSREF]
- Ramamoorthy , L , Kemp , M C and Tizard , I R . 1996 . Acemannan, a beta-(1,4)-acetylated mannan, induces nitric oxide production in macrophage cell line RAW 264.7 . Mol Pharmacol , 50 : 878 – 884 . [INFOTRIEVE] [CSA]
- Ramamoorthy , L and Tizard , I R . 1998 . Induction of apoptosis in a macrophage cell line RAW 264.7 by acemannan, a beta-(1,4)-acetylated mannan . Mol Pharmacol , 53 : 415 – 421 . [INFOTRIEVE] [CSA]
- Karaca , K , Sharma , J M and Nordgren , R . 1995 . Nitric oxide production by chicken macrophages activated by Acemannan, a complex carbohydrate extracted from Aloe vera . Int J Immunopharmacol , 17 : 183 – 188 . [INFOTRIEVE] [CSA] [CROSSREF]
- Banchereau , J , Briere , F , Caux , C , Davoust , J , Lebecque , S , Liu , Y J , Pulendran , B and Palucka , K . 2000 . Immunobiology of dendritic cells . Annu Rev Immunol , 18 : 767 – 811 . [INFOTRIEVE] [CSA] [CROSSREF]
- Lee , J K , Lee , M K , Yun , Y P , Kim , Y , Kim , J S , Kim , Y S , Kim , K , Han , S S and Lee , C K . 2001 . Acemannan purified from A loe vera induces phenotypic and functional maturation of immature dendritic cells . Int Immunopharmacol , 1 : 1275 – 1284 . [INFOTRIEVE] [CSA] [CROSSREF]
- Hu , Y , Xu , J and Hu , Q . 2003 . Evaluation of antioxidant potential of Aloe vera (Aloe barbadensis Miller) extracts . Journal of Agric. Food Chemistry , 51 : 7788 – 7791 . [CSA] [CROSSREF]
- t'Hart , L A , van Enckevort , P H , van Dijk , H , Zaat , R , de Silva , K TD and Labadie , R P . 1988 . Two functionally and chemically distinct immunomodulatory compounds in the gel of Aloe vera . Journal of Ethnopharmacology , 23 : 61 – 71 . [CSA] [CROSSREF]
- Rajasekaran , S , Sivagnanam , K and Subramanian , S . 2005 . Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats . Pharmacol Rep , 57 : 90 – 96 . [INFOTRIEVE] [CSA]
- Saada , H N , Ussama , Z S and Mahdy , A M . 2003 . Effectiveness of Aloe vera on the antioxidant status of different tissues in irradiated rats . Pharmazie , 58 : 929 – 931 . [INFOTRIEVE] [CSA]
- Vázquez , B , Avila , G , Segura , D and Escalante , B . 1996 . Antiinflammatory activity of extracts from Aloe vera gel . J Ethnopharmacol , 55 : 69 – 75 . [CSA] [CROSSREF]
- Langmead , L , Makins , R J and Rampton , D S . 2004 . Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro . Aliment Pharmacol Ther , 19 : 521 – 527 . [INFOTRIEVE] [CSA] [CROSSREF]
- Duansak , D , Somboonwong , J and Patumraj , S . 2003 . Effects of Aloe vera on leukocyte adhesion and TNF-alpha and IL-6 levels in burn wounded rats . Clin Hemorheol Microcirc , 29 : 239 – 246 . [INFOTRIEVE] [CSA]
- Peng , S Y , Norman , J , Curtin , G , Corrier , D , McDaniel , H R and Busbee , D . 1991 . Decreased mortality of Norman murine sarcoma in mice treated with the immunomodulator, Acemannan . Mol Biother , 3 : 79 – 87 . [INFOTRIEVE] [CSA]
- Strickland , F M , Pelley , R P and Kripke , M L . 1994 . Prevention of ultraviolet radiation-induced suppression of contact and delayed hypersensitivity by Aloe barbadensis gel extract . J Invest Dermatol , 102 : 197 – 204 . [INFOTRIEVE] [CSA]
- Lee , C K , Han , S S , Shin , Y K , Chung , M H , Park , Y I , Lee , S K and Kim , Y S . 1999 . Prevention of ultraviolet radiation-induced suppression of contact hypersensitivity by Aloe vera gel components . Int J Immunopharmacol , 21 : 303 – 310 . [INFOTRIEVE] [CSA] [CROSSREF]
- Byeon , S W , Pelley , R P , Ullrich , S E , Waller , T A , Bucana , C D and Strickland , F M . 1998 . Aloe barbadensis extracts reduce the production of interleukin-10 after exposure to ultraviolet radiation . J Invest Dermatol , 110 : 811 – 817 . [INFOTRIEVE] [CSA] [CROSSREF]
- Penneys , N S . 1982 . Inhibition of arachidonic acid oxidation in vitro by vehicle components . Acta Derm Venereol , 62 : 59 – 61 . [INFOTRIEVE] [CSA]
- Crowell , J , Hilsenbeck , S and Penneys , N . 1989 . Aloe vera does not affect cutaneous erythema and blood flow following ultraviolet B exposure . Photodermatol , 6 : 237 – 239 . [INFOTRIEVE] [CSA]
- Langmead , L , Feakins , R M , Goldthorpe , S , Holt , H , Tsironi , E , De Silva , A , Jewell , D P and Rampton , D S . 2004 . Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis . Aliment Pharmacol Ther , 19 : 739 – 747 . [INFOTRIEVE] [CSA] [CROSSREF]
- Womble , D and Helderman , J H . 1988 . Enhancement of allo-responsiveness of human lymphocytes by acemannan (Carrisyn) . Int J Immunopharmacol , 10 : 967 – 974 . [INFOTRIEVE] [CSA] [CROSSREF]
- Gelderman , M P , Lefkowitz , D L , Lefkowitz , S S , Bollen , A and Moguilevsky , N . 1998 . Exposure of macrophages to an enzymatically inactive macrophage mannose receptor ligand augments killing of Candida albicans . Proc Soc Exp Biol Med , 217 : 81 – 88 . [INFOTRIEVE] [CSA]
- Stuart , R W , Lefkowitz , D L , Lincoln , J A , Howard , K , Gelderman , M P and Lefkowitz , S S . 1997 . Upregulation of phagocytosis and candidicidal activity of macrophages exposed to the immunostimulant acemannan . Int J Immunopharmacol , 19 : 75 – 82 . [INFOTRIEVE] [CSA] [CROSSREF]
- Barmak , K , Harhaj , E , Grant , C , Alefantis , T and Wigdahl , B . 2003 . Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration . Virology , 308 : 1 – 12 . [INFOTRIEVE] [CSA] [CROSSREF]
- Yates , K M , Rosenberg , L J , Harris , C K , Bronstad , D C , King , G K , Biehle , G A , Walker , B , Ford , C R , Hall , J E and Tizard , I R . 1992 . Pilot study of the effect of acemannan in cats infected with feline immunodeficiency virus . Vet Immunol Immunopathol , 35 : 177 – 189 . [INFOTRIEVE] [CSA] [CROSSREF]
- Kahlon , J B , Kemp , M C , Yawei , N , Carpenter , R H , Shannon , W M and Mc Analley , B H . 1991 . In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir . Mol Biother , 3 : 214 – 223 . [INFOTRIEVE] [CSA]
- Ferro , V A , Bradbury , F , Cameron , P , Shakir , E , Rahman , S R and Stimson , W H . 2003 . In vitro susceptibilities of Shigella flexneri and Streptococcus pyogenes to inner gel of Aloe barbadensis Miller . Antimicrob Agents Chemother , 47 : 1137 – 1139 . [INFOTRIEVE] [CSA] [CROSSREF]
- Moody , J O , Adebiyi , O A and Adeniyi , B A . 2004 . Do Aloe vera and Ageratum conyzoides enhance the anti-microbial activity of traditional medicinal soft soaps (Osedudu)? . J Ethnopharmacol , 92 : 57 – 60 . [INFOTRIEVE] [CSA] [CROSSREF]
- Harris , C , Pierce , K , King , G , Yates , K M , Hall , J and Tizard , I . 1991 . Efficacy of acemannan in treatment of canine and feline spontaneous neoplasms . Mol Biother , 3 : 207 – 213 . [INFOTRIEVE] [CSA]
- King , G K , Yates , K M , Greenlee , P G , Pierce , K R , Ford , C R , McAnalley , B H and Tizard , I R . 1995 . The effect of Acemannan Immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcomas . J Am Anim Hosp Assoc , 31 : 439 – 447 . [INFOTRIEVE] [CSA]
- Kim , H S and Lee , B M . 1997 . Inhibition of benzo[a]pyrene-DNA adduct formation by Aloe barbadensisMiller . Carcinogenesis , 18 : 771 – 776 . [INFOTRIEVE] [CSA] [CROSSREF]
- Shamaan , N A , Kadir , K A , Rahmat , A and Ngah , W Z . 1998 . Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat . Nutrition , 14 : 846 – 852 . [INFOTRIEVE] [CSA] [CROSSREF]
- Lissoni , P , Giani , L , Zerbini , S , Trabattoni , P and Rovelli , F . 1998 . Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus Aloe vera in untreatable advanced solid neoplasms . Nat Immun , 16 : 27 – 33 . [INFOTRIEVE] [CSA] [CROSSREF]
- Fogleman , R W , Chapdelaine , J M , Carpenter , R H and McAnalley , B H . 1992 . Toxicologic evaluation of injectable acemannan in the mouse, rat and dog . Vet Hum Toxicol , 34 : 201 – 205 . [INFOTRIEVE] [CSA]
- Fogleman , R W , Shellenberger , T E , Balmer , M F , Carpenter , R H and McAnalley , B H . 1992 . Subchronic oral administration of acemannan in the rat and dog . Vet Hum Toxicol , 34 : 144 – 147 . [INFOTRIEVE] [CSA]
- Shah , A H , Quereshi , S , Tariq , M and Ageel , A M . 1989 . Toxicity studies on six plants used in the traditional arab system of medicine . Phytother Res , 3 : 25 – 28 . [CSA]
- Herlihy , J T , Bertrand , H A , Kim , J D , Ikeno , Y and Yu , B P . 1998 . Effects of aloe vera ingestion in the rat I. Growth, food and fluid intake and serum chemistry . Phytother Res , 12 : 183 – 188 . [CSA] [CROSSREF]
- Herlihy , J T , Kim , J D , Katu , D N , Nelson , J F , Ward , W F , Ikeno , Y and Yu , B P . 1998 . Effects of aloe vera ingestion in the rat. II. Hormonal and metabolic characteristics . Phytother Res , 12 : 355 – 360 . [CSA] [CROSSREF]
- Ikeno , Y , Hubbard , G B , Lee , S , Yu , B P and Herlihy , J T . 2002 . The influence of long-term Aloe vera ingestion on age-related disease in male Fischer 344 rats . Phytother Res , 16 : 712 – 718 . [INFOTRIEVE] [CSA] [CROSSREF]
- Lim , B O , Seong , N S , Choue , R W , Kim , J D , Lee , H Y , Kim , S Y , Yu , B P , Jeon , T I and Park , D K . 2003 . Efficacy of dietary aloe vera supplementation on hepatic cholesterol and oxidative status in aged rats . J Nutr Sci Vitaminol (Tokyo) , 49 : 292 – 296 . [CSA]
- Rabe , C , Musch , A , Schirmacher , P , Kruis , W and Hoffmann , R . 2005 . Acute hepatitis induced by an Aloe vera preparation: a case report . World J Gastroenterol , 11 : 303 – 304 . [INFOTRIEVE] [CSA]
- Mascolo , N , Izzo , A A , Borelli , F , Capasso , R , DiCarlo , G , Sautebin , L and Capasso , F . 2004 . “ Healing powers of aloes ” . In Aloes: The Genus Aloe, , 2003 edition , Edited by: Reynolds , T. Vol. 38 , 209 – 238 . Boca Raton, FL : CRC Press .
- Dominguez-Soto , L . 1992 . Photodermatitis to aloe vera . Int J Dermatol , 31 : 372 [PUBMED] [INFOTRIEVE] [CSA]
- Hunter , D and Frumkin , A . 1991 . Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel . Cutis , 47 : 193 – 196 . [INFOTRIEVE] [CSA]
- Morrow , D M , Rapaport , M J and Strick , R A . 1980 . Hypersensitivity to aloe . Arch Dermatol , 116 : 1064 – 1065 . [INFOTRIEVE] [CSA] [CROSSREF]
- Hattori , M , Akao , T , Kobashi , K and Namba , T . 1993 . Cleavages of the O- and C-glucosyl bonds of anthrone and 10,10′-bianthrone derivatives by human intestinal bacteria . Pharmacology , 47 ( Suppl 1 ) : 125 – 133 . [INFOTRIEVE] [CSA]
- van Gorkom , B A , de Vries , E G , Karrenbeld , A and Kleibeuker , J H . 1999 . Review article: anthranoid laxatives and their potential carcinogenic effects . Aliment Pharmacol Ther , 13 : 443 – 452 . [INFOTRIEVE] [CSA] [CROSSREF]
- Akao , T , Che , Q M , Kobashi , K , Hattori , M and Namba , T . 1996 . A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodin anthrone . Biol Pharm Bull , 19 : 136 – 138 . [INFOTRIEVE] [CSA]
- deWitte , P . 1993 . Metabolism and pharmacokinetics of anthranoids . Pharmacology , 47 : 86 – 97 . [CSA]
- Sendelbach , L E . 1989 . A review of the toxicity and carcinogenicity of anthraquinone derivatives . Toxicology , 57 : 227 – 240 . [INFOTRIEVE] [CSA] [CROSSREF]
- Stolk , L M and Hoogtanders , K . 1999 . Detection of laxative abuse by urine analysis with HPLC and diode array detection . Pharm World Sci , 21 : 40 – 43 . [INFOTRIEVE] [CSA] [CROSSREF]
- deWitte , P and Lemli , L . 1990 . The metabolism of anthranoid laxatives . Hepatogastroenterol , 37 : 601 – 605 . [CSA]
- Lang , W . 1993 . Pharmacokinetic-metabolic studies with 14C-aloe emodin after oral administration to male and female rats . Pharmacology , 47 ( Suppl 1 ) : 110 – 119 . [INFOTRIEVE] [CSA]
- Krumbiegel , G and Schulz , H U . 1993 . Rhein and aloe-emodin kinetics from senna laxatives in man . Pharmacology , 47 ( Suppl 1 ) : 120 – 124 . [INFOTRIEVE] [CSA]
- Fantus , B . 1922 . Aloes as a medicine . Journal of the American Pharmaceutical Association , 11 : 616 – 621 . [CSA]
- Ishii , Y , Tanizawa , H and Takino , Y . 1993 . Rat selection test with respect to laxative activity induced by barbaloin . Biol Pharm Bull , 16 : 1040 [INFOTRIEVE] [CSA]
- Ishii , Y , Takino , Y , Toyo'oka , T and Tanizawa , H . 1998 . Studies of aloe. VI. Cathartic effect of isobarbaloin . Biol Pharm Bull , 21 : 1226 – 1227 . [INFOTRIEVE] [CSA]
- Ishii , Y , Tanizawa , H and Takino , Y . 1990 . Studies of aloe. III. Mechanism of cathartic effect. (2) . Chem Pharm Bull (Tokyo) , 38 : 197 – 200 . [CSA]
- Koch , A . 1996 . Metabolism of aloin–the influence of nutrition . J Pharm Biomed Anal , 14 : 1335 – 1338 . [INFOTRIEVE] [CSA] [CROSSREF]
- Yagi , T and Yamauchi , K . 1999 . Synergistic effects of anthraquinones on the purgative activity of rhein anthrone in mice . J Pharm Pharmacol , 51 : 93 – 95 . [INFOTRIEVE] [CSA]
- Ishii , Y , Tanizawa , H and Takino , Y . 1994 . Studies of aloe. V. Mechanism of cathartic effect. (4) . Biol Pharm Bull , 17 : 651 – 653 . [INFOTRIEVE] [CSA]
- Capasso , F , Mascolo , N , Autore , G and Duraccio , M R . 1983 . Effect of indomethacin on aloin and 1,8 dioxianthraquinone-induced production of prostaglandins in rat isolated colon . Prostaglandins , 26 : 557 – 562 . [INFOTRIEVE] [CSA] [CROSSREF]
- Kai , M , Hayashi , K , Kaida , I , Aki , H and Yamamoto , M . 2002 . Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa . Biol Pharm Bull , 25 : 1608 – 1613 . [INFOTRIEVE] [CSA] [CROSSREF]
- Izzo , A A , Mascolo , N and Capasso , F . 1998 . Nitric oxide as a modulator of intestinal water and electrolyte transport . Dig Dis Sci , 43 : 1605 – 1620 . [INFOTRIEVE] [CSA] [CROSSREF]
- Izzo , A A , Sautebin , L , Borrelli , F , Longo , R and Capasso , F . 1999 . The role of nitric oxide in aloe-induced diarrhoea in the rat . Eur J Pharmacol , 368 : 43 – 48 . [INFOTRIEVE] [CSA] [CROSSREF]
- Mijatovic , S , Maksimovic-Ivanic , D , Radovic , J , Popadic , D , Momcilovic , M , Harhaji , L , Miljkovic , D and Trajkovic , V . 2004 . Aloe-emodin prevents cytokine-induced tumor cell death: the inhibition of auto-toxic nitric oxide release as a potential mechanism . Cell Mol Life Sci , 61 : 1805 – 1815 . [INFOTRIEVE] [CSA] [CROSSREF]
- Barrantes , E and Guinea , M . 2003 . Inhibition of collagenase and metalloproteinases by aloins and aloe gel . Life Sci , 72 : 843 – 850 . [INFOTRIEVE] [CSA]
- 'tHart , L A , Nibbering , P H , Barselaar , M TVD , Dijk , H V , Berg , A JVD , Berg , P and Labadie , R . 1990 . Effects of low molecular constituents from Aloe vera gel on oxidative metabolism and cytotoxic and bactericidal activities of human neutrophils . Int J Immunopharmacol , 12 : 427 – 434 . [CSA]
- Alves , D S , Perez-Fons , L , Estepa , A and Micol , V . 2004 . Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin . Biochem Pharmacol , 68 : 549 – 561 . [INFOTRIEVE] [CSA] [CROSSREF]
- Sydiskis , R J , Owen , D G , Lohr , J L , Rosler , K H and Blomster , R N . 1991 . Inactivation of enveloped viruses by anthraquinones extracted from plants . Antimicrob Agents Chemother , 35 : 2463 – 2466 . [INFOTRIEVE] [CSA]
- Andersen , D O , Weber , N D , Wood , S G , Hughes , B G , Murray , B K and North , J A . 1991 . In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives . Antiviral Res , 16 : 185 – 196 . [INFOTRIEVE] [CSA] [CROSSREF]
- Levin , H , Hazenfratz , R , Friedman , J , Pelevitch , D and Perl , M . 1988 . Partial purification and some properties of an antibacterial compound from Aloe vera . Phytother Res , 2 : 67 – 69 . [CSA]
- Friedmann , C A . 1980 . Structure-activity relationships of anthraquinones in some pathological conditions . Pharmacology , 20 : 113 – 122 . [INFOTRIEVE] [CSA]
- Yen , G -C , Duh , P -D and Chuang , D -Y . 2000 . Antioxidant activity of anthraquinones and anthrone . Food Chemistry , 70 : 437 – 441 . [CSA] [CROSSREF]
- Arosio , B , Gagliano , N , Fusaro , L M , Parmeggiani , L , Tagliabue , J , Galetti , P , De Castri , D , Moscheni , C and Annoni , G . 2000 . Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride . Pharmacol Toxicol , 87 : 229 – 233 . [INFOTRIEVE] [CSA] [CROSSREF]
- Wamer , W G , Vath , P and Falvey , D E . 2003 . In vitro studies on the photobiological properties of aloe emodin and aloin A . Free Radical Biology and Medicine , 34 : 233 – 242 . [INFOTRIEVE] [CSA] [CROSSREF]
- Vargas , F , Fraile , G , Velasquez , M , Correia , H , Fonseca , G , Marin , M , Marcano , E and Sanchez , Y . 2002 . Studies on the photostability and phototoxicity of aloe-emodin, emodin and rhein . Pharmazie , 57 : 399 – 404 . [INFOTRIEVE] [CSA]
- Vath , P , Wamer , W G and Falvey , D E . 2002 . Photochemistry and phototoxicity of aloe emodin . Photochem Photobiol , 75 : 346 – 352 . [INFOTRIEVE] [CSA] [CROSSREF]
- Grimaudo , S , Tolomeo , M , Gancitano , R A , D'Alessandro , N and Aiello , E . 1997 . Effects of highly purified anthraquinoid compounds from Aloe vera on sensitive and multidrug resistant leukemia cells . Oncology Reports , 4 : 341 – 343 . [CSA]
- Chen , H C , Hsieh , W T , Chang , W C and Chung , J G . 2004 . Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells . Food Chem Toxicol , 42 : 1251 – 1257 . [INFOTRIEVE] [CSA] [CROSSREF]
- Lee , H Z . 2001 . Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell . Br J Pharmacol , 134 : 1093 – 1103 . [INFOTRIEVE] [CSA] [CROSSREF]
- Lee , H Z , Hsu , S L , Liu , M C and Wu , C H . 2001 . Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma . Eur J Pharmacol , 431 : 287 – 295 . [INFOTRIEVE] [CSA] [CROSSREF]
- Yeh , F T , Wu , C H and Lee , H Z . 2003 . Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell . Int J Cancer , 106 : 26 – 33 . [INFOTRIEVE] [CSA] [CROSSREF]
- Kuo , P L , Lin , T C and Lin , C C . 2002 . The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines . Life Sci , 71 : 1879 – 1892 . [INFOTRIEVE] [CSA] [CROSSREF]
- Mijatovic , S , Maksimovic-Ivanic , D , Radovic , J , Miljkovic , D , Kaludjerovic , G N , Sabo , T J and Trajkovic , V . 2005 . Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin . Cell Mol Life Sci , 18 : 5041 – 5043 . [CSA]
- Westendorf , J , Marquardt , H , Poginsky , B , Dominiak , M , Schmidt , J and Marquardt , H . 1990 . Genotoxicity of naturally occurring hydroxyanthraquinones . Mutat Res , 240 : 1 – 12 . [INFOTRIEVE] [CSA] [CROSSREF]
- Mueller , S O , Eckert , I , Lutz , W K and Stopper , H . 1996 . Genotoxicity of the laxative drug components emodin, aloe-emodin and danthron in mammalian cells: topoisomerase II mediated? . Mutat Res , 371 : 165 – 173 . [CSA] [CROSSREF]
- Kodama , M , Kamioka , Y , Nakayama , T , Nagata , C , Morooka , N and Ueno , Y . 1987 . Generation of free radical and hydrogen peroxide from 2-hydroxyemodin, a direct-acting mutagen, and DNA strand breaks by active oxygen . Toxicol Lett , 37 : 149 – 156 . [INFOTRIEVE] [CSA] [CROSSREF]
- Mueller , S O , Lutz , W K and Stopper , H . 1998 . Factors affecting the genotoxic potency ranking of natural anthraquinones in mammalian cell culture systems . Mutat Res , 414 : 125 – 129 . [INFOTRIEVE] [CSA]
- Mueller , S O , Stopper , H and Dekant , W . 1998 . Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes. Bioactivation to genotoxic metabolites . Drug Metab Dispos , 26 : 540 – 546 . [INFOTRIEVE] [CSA]
- Mueller , S O and Stopper , H . 1999 . Characterization of the genotoxicity of anthraquinones in mammalian cells . Biochim Biophys Acta , 1428 : 406 – 414 . [INFOTRIEVE] [CSA]
- Wolfe , D , Schmutte , C , Westendorf , J and Marquardt , H . 1990 . Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes . Cancer Res , 50 : 6540 – 6544 . [CSA]
- Schorkhuber , M , Richter , M , Dutter , A , Sontag , G and Marian , B . 1998 . Effect of anthraquinone-laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells . Eur J Cancer , 34 : 1091 – 1098 . [INFOTRIEVE] [CSA] [CROSSREF]
- Cooke , W T . 1981 . Laxative abuse . Acta Gastro-Enterol Belg , 44 : 448 – 458 . [CSA]
- Heizer , W D , Warshaw , A L , Waldmann , T A and Laster , L . 1968 . Protein-losing gastroenteropathy and malabsorption associated with factitious diarrhea . Ann Intern Med , 68 : 839 – 852 . [INFOTRIEVE] [CSA]
- Perkins , J G , Petersen , A B and Riley , J A . 1950 . Renal and cardiac lesions in potassium deficiency due to chronic diarrhea . Am J Med , 8 : 115 – 123 . illust[INFOTRIEVE] [CSA] [CROSSREF]
- Evangelos , C , Spyros , K and Spyros , D . 2005 . Henoch-Schonlein purpura associated with Aloe vera administration . Eur J Intern Med , 16 : 59 – 60 . [INFOTRIEVE] [CSA] [CROSSREF]
- Luyckx , V A , Ballantine , R , Claeys , M , Cuyckens , F , Van den Heuvel , H , Cimanga , R K , Vlietinck , A J , Broe , M E and Katz , I J . 2002 . Herbal remedy-associated acute renal failure secondary to Cape aloes . American Journal of Kidney Diseases , 39 : 1 – 5 . [CSA] [CROSSREF]
- Abebe , W . 2003 . An overview of herbal supplement utilization with particular emphasis on possible interactions with dental drugs and oral manifestations . J Dent Hyg , 77 : 37 – 46 . [INFOTRIEVE] [CSA]
- Siegers , C P , von Hertzberg-Lottin , E , Otte , M and Schneider , B . 1993 . Anthranoid laxative abuse–a risk for colorectal cancer? . Gut , 34 : 1099 – 1101 . [INFOTRIEVE] [CSA]
- Willems , M , van Buuren , H R and de Krijger , R . 2003 . Anthranoid self-medication causing rapid development of melanosis coli . Neth J Med , 61 : 22 – 24 . [INFOTRIEVE] [CSA]
- Strickland , F M , Muller , H K , Stephens , L C , Bucana , C D , Donawho , C K , Sun , Y and Pelley , R P . 2000 . Induction of primary cutaneous melanomas in C3H mice by combined treatment with ultraviolet radiation, ethanol and aloe emodin . Photochem Photobiol , 72 : 407 – 414 . [INFOTRIEVE] [CSA] [CROSSREF]
- Badgwell , D B , Walker , C M , Baker , W T and Strickland , F M . 2004 . Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumors . Mol Carcinog , 39 : 127 – 138 . [INFOTRIEVE] [CSA] [CROSSREF]
- Alles , M S , Hartemink , R , Meyboom , S , Harryvan , J L , Van Laere , K M , Nagengast , F M and Hautvast , J G . 1999 . Effect of transgalactooligosaccharides on the composition of the human intestinal microflora and on putative risk markers for colon cancer . Am J Clin Nutr , 69 : 980 – 991 . [INFOTRIEVE] [CSA]
- Cummings , J H and Bingham , S A . 1998 . Diet and the prevention of cancer . British Medical Journal , 317 : 1636 – 1640 . [PUBMED] [INFOTRIEVE] [CSA]
- Cummings , J H . 1998 . Dietary carbohydrates and the colonic microflora . Curr Opin Clin Nutr Metab Care , 1 : 409 – 414 . [INFOTRIEVE] [CSA] [CROSSREF]
- Yuan , H , Liddle , F J , Mahajan , S and Frank , D A . 2004 . IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor . Carcinogenesis , 25 : 2247 – 2255 . [INFOTRIEVE] [CSA] [CROSSREF]
- Cummings , J H and Macfarlane , G T . 1997 . Role of intestinal bacteria in nutrient metabolism . JPEN J Parenter Enteral Nutr , 21 : 357 – 365 . [INFOTRIEVE] [CSA]
- Chapman , M . 1995 . Re: Excessively high cell proliferation in sigmoid colon after an oral purge with anthraquinone glycosides [letter; comment] . J Natl Cancer Inst , 87 : 1086 – 1087 . [PUBMED] [INFOTRIEVE] [CSA]
- Borins , M . 1998 . The danger of using herbs: what your patients need to know . Postgraduate Medicine , 104 : 91 – 100 . [INFOTRIEVE] [CSA]
- Schenkel , B and Vorherr , H . 1974 . Non-prescription drugs during pregnancy: potential teratogenic and toxic effects upon embryo and fetus . J Reprod Med , 12 : 27 – 45 . [INFOTRIEVE] [CSA]
- Mori , H , Sugie , S , Niwa , K , Takahashi , M and Kawai , K . 1985 . Induction of intestinal tumours in rats by chrysazin . Br J Cancer , 52 : 781 – 783 . [INFOTRIEVE] [CSA]
- Vogler , B K and Ernst , E . 1999 . Aloe vera: a systematic review of its clinical effectiveness . Br J Gen Pract , 49 : 823 – 828 . [INFOTRIEVE] [CSA]