The Role of MicroRNA in Chemical Carcinogenesis

REFERENCES

• Ventura , A and Jacks , T . 2009 . MicroRNAs and cancer: short RNAs go a long way . Cell. , 136 ( 4 ) : 586 – 91 .
   PubMed Web of Science ®Google Scholar
• Stallings , R L . 2009 . MicroRNA involvement in the pathogenesis of neuroblastoma: potential for microRNA mediated therapeutics . Curr Pharm Des. , 15 ( 4 ) : 456 – 462 .
   PubMed Web of Science ®Google Scholar
• Croce , C M . 2009 . Causes and consequences of microRNA dysregulation in cancer . Nat Rev Genet. , 10 ( 10 ) : 704 – 714 .
   PubMed Web of Science ®Google Scholar
• Lu , J , Getz , G , Miska , E A , Alvarez-Saavedra , E , Lamb , J , Peck , D , Sweet-Cordero , A , Ebert , B L , Mak , R H , Ferrando , A A , Downing , J R , Jacks , T , Horvitz , H R and Golub , T R . 2005 . MicroRNA expression profiles classify human cancers . Nature. , 435 ( 7043 ) : 834 – 838 .
   PubMed Web of Science ®Google Scholar
• Volinia , S , Calin , G A , Liu , C G , Ambs , S , Cimmino , A , Petrocca , F , Visone , R , Iorio , M , Roldo , C , Ferracin , M , Prueitt , R L , Yanaihara , N , Lanza , G , Scarpa , A , Vecchione , A , Negrini , M , Harris , C C and Croce , C M . 2006 . A microRNA expression signature of human solid tumors defines cancer gene targets . Proc Natl Acad Sci U S A. , 103 ( 7 ) : 2257 – 2261 .
   PubMed Web of Science ®Google Scholar
• Shi , M and Guo , N . 2009 . MicroRNA expression and its implications for the diagnosis and therapeutic strategies of breast cancer . Cancer Treat Rev. , 35 ( 4 ) : 328 – 334 .
   PubMedGoogle Scholar
• Lynam-Lennon , N , Maher , S G and Reynolds , J V . 2009 . The roles of microRNA in cancer and apoptosis . Biol Rev Camb Philos Soc. , 84 ( 1 ) : 55 – 71 .
   PubMed Web of Science ®Google Scholar
• Hagan , J P and Croce , C M . 2007 . MicroRNAs in carcinogenesis . Cytogenet Genome Res. , 118 ( 2–4 ) : 252 – 259 .
   PubMedGoogle Scholar
• Kalscheuer , S , Zhang , X , Zeng , Y and Upadhyaya , P . 2008 . Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone . Carcinogenesis. , 29 ( 12 ) : 2394 – 2399 .
   PubMed Web of Science ®Google Scholar
• Pogribny , I P , Tryndyak , V P , Boyko , A , Rodriguez-Juarez , R , Beland , F A and Kovalchuk , O . 2007 . Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure . Mutat Res. , 619 ( 1–2 ) : 30 – 37 .
   PubMed Web of Science ®Google Scholar
• Kumamoto , K , Spillare , E A , Fujita , K , Horikawa , I , Yamashita , T , Appella , E , Nagashima , M , Takenoshita , S , Yokota , J and Harris , C C . 2008 . Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence . Cancer Res. , 68 ( 9 ) : 3193 – 3203 .
   PubMed Web of Science ®Google Scholar
• Tryndyak , V P , Ross , S A , Beland , F A and Pogribny , I P . 2009 . Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet . Mol Carcinog. , 48 ( 6 ) : 479 – 487 .
   PubMed Web of Science ®Google Scholar
• Kovalchuk , O , Tryndyak , V P , Montgomery , B , Boyko , A , Kutanzi , K , Zemp , F , Warbritton , A R , Latendresse , J R , Kovalchuk , I , Beland , F A and Pogribny , I P . 2007 . Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression . Cell Cycle. , 6 ( 16 ) : 2010 – 2018 .
   PubMed Web of Science ®Google Scholar
• Davidson , L A , Wang , N , Shah , M S , Lupton , J R , Ivanov , I and Chapkin , R S . 2009 . n-3 polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon . Carcinogenesis. , 30 ( 12 ) : 2077 – 2084 .
   PubMedGoogle Scholar
• Melkamu , T , Zhang , X , Tan , J , Zeng , Y and Kassie , F . 2010 . Alteration of microRNA expression in vinyl-carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol . Carcinogenesis. , 31 ( 2 ) : 252 – 258 .
   PubMed Web of Science ®Google Scholar
• Shen , Y L , Jiang , Y G , Greenlee , A R , Zhou , L L and Liu , L H . 2009 . MicroRNA expression profiles and miR-10a target in anti-benzo[a] pyrene-7, 8-diol-9, 10-epoxide-transformed human 16HBE cells . Biomed Environ Sci. , 22 ( 1 ) : 14 – 21 .
   PubMed Web of Science ®Google Scholar
• Yu , T , Wang , X Y , Gong , R G , Li , A , Yang , S , Cao , Y T , Wen , Y M , Wang , C M and Yi , X Z . 2009 . The expression profile of microRNAs in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in Syrian hamster . J Exp Clin Cancer Res. , 28 ( 64 )
   Google Scholar
• Ambros , V . 2003 . MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing . Cell. , 113 ( 6 ) : 673 – 676 .
   PubMed Web of Science ®Google Scholar
• Bartel , D P . 2004 . MicroRNAs: genomics, biogenesis, mechanism, and function . Cell. , 116 ( 2 ) : 281 – 297 .
   PubMed Web of Science ®Google Scholar
• Lee , R C , Feinbaum , R L and Ambros , V . 1993 . The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 . Cell. , 75 ( 5 ) : 843 – 854 .
   PubMed Web of Science ®Google Scholar
• Reinhart , B J , Slack , F J , Basson , M , Pasquinelli , A E , Bettinger , J C , Rougvie , A E , Horvitz , H R and Ruvkun , G . 2000 . The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans . Nature. , 403 ( 6772 ) : 901 – 906 .
   PubMed Web of Science ®Google Scholar
• Lin , S Y , Johnson , S M , Abraham , M , Vella , M C , Pasquinelli , A , Gamberi , C , Gottlieb , E and Slack , F J . 2003 . The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target . Dev Cell. , 4 ( 5 ) : 639 – 650 .
   PubMedGoogle Scholar
• Abrahante , J E , Daul , A L , Li , M , Volk , M L , Tennessen , J M , Miller , E A and Rougvie , A E . 2003 . The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs . Dev Cell. , 4 ( 5 ) : 625 – 637 .
   PubMed Web of Science ®Google Scholar
• Slack , F J , Basson , M , Liu , Z , Ambros , V , Horvitz , H R and Ruvkun , G . 2000 . The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor . Mol Cell. , 5 ( 4 ) : 659 – 669 .
   PubMed Web of Science ®Google Scholar
• Vella , M C , Choi , E Y , Lin , S Y , Reinert , K and Slack , F J . 2004 . The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3’UTR . Genes Dev. , 18 ( 2 ) : 132 – 137 .
   PubMedGoogle Scholar
• Shivdasani , R A . 2006 . MicroRNAs: regulators of gene expression and cell differentiation . Blood. , 108 ( 12 ) : 3646 – 3653 .
   PubMed Web of Science ®Google Scholar
• Aukerman , M J and Sakai , H . 2003 . Regulation of flowering time and floral organ identity by a MicroRNA and its APETALA2-like target genes . Plant Cell. , 15 ( 11 ) : 2730 – 2741 .
   PubMed Web of Science ®Google Scholar
• Johnston , R J and Hobert , O . 2003 . A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans . Nature. , 426 ( 6968 ) : 845 – 849 .
   PubMed Web of Science ®Google Scholar
• Mott , J L . 2009 . MicroRNAs involved in tumor suppressor and oncogene pathways: implications for hepatobiliary neoplasia . Hepatology. , 50 ( 2 ) : 630 – 637 .
   PubMedGoogle Scholar
• Cummins , J M and Velculescu , V E . 2006 . Implications of micro-RNA profiling for cancer diagnosis . Oncogene. , 25 ( 46 ) : 6220 – 6227 .
   PubMed Web of Science ®Google Scholar
• Lau , N C , Lim , L P , Weinstein , E G and Bartel , D P . 2001 . An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans . Science. , 294 ( 5543 ) : 858 – 862 .
   PubMed Web of Science ®Google Scholar
• Lagos-Quintana , M , Rauhut , R , Lendeckel , W and Tuschl , T . 2001 . Identification of novel genes coding for small expressed RNAs . Science. , 294 ( 5543 ) : 853 – 858 .
   PubMed Web of Science ®Google Scholar
• Lee , Y , Kim , M , Han , J , Yeom , K H , Lee , S , Baek , S H and Kim , V N . 2004 . MicroRNA genes are transcribed by RNA polymerase II . Embo J. , 23 ( 20 ) : 4051 – 4060 .
   PubMed Web of Science ®Google Scholar
• Cai , X , Hagedorn , C H and Cullen , B R . 2004 . Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs . Rna. , 10 ( 12 ) : 1957 – 1966 .
   PubMed Web of Science ®Google Scholar
• Han , J , Lee , Y , Yeom , K H , Kim , Y K , Jin , H and Kim , V N . 2004 . The Drosha-DGCR8 complex in primary microRNA processing . Genes Dev. , 18 ( 24 ) : 3016 – 3027 .
   PubMed Web of Science ®Google Scholar
• Lee , Y , Ahn , C , Han , J , Choi , H , Kim , J , Yim , J , Lee , J , Provost , P , Radmark , O , Kim , S and Kim , V N . 2003 . The nuclear RNase III Drosha initiates microRNA processing . Nature. , 425 ( 6956 ) : 415 – 419 .
   PubMed Web of Science ®Google Scholar
• Han , J , Lee , Y , Yeom , K H , Nam , J W , Heo , I , Rhee , J K , Sohn , S Y , Cho , Y , Zhang , B T and Kim , V N . 2006 . Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex . Cell. , 125 ( 5 ) : 887 – 901 .
   PubMed Web of Science ®Google Scholar
• Lee , Y , Jeon , K , Lee , J T , Kim , S and Kim , V N . 2002 . MicroRNA maturation: stepwise processing and subcellular localization . Embo J. , 21 ( 17 ) : 4663 – 4670 .
   PubMed Web of Science ®Google Scholar
• Kim , V N . 2004 . MicroRNA precursors in motion: exportin-5 mediates their nuclear export . Trends Cell Biol. , 14 ( 4 ) : 156 – 159 .
   PubMedGoogle Scholar
• Lund , E , Guttinger , S , Calado , A , Dahlberg , J E and Kutay , U . 2004 . Nuclear export of microRNA precursors . Science. , 303 ( 5654 ) : 95 – 98 .
   PubMed Web of Science ®Google Scholar
• Bohnsack , M T , Czaplinski , K and Gorlich , D . 2004 . Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs . RNA. , 10 ( 2 ) : 185 – 191 .
   PubMed Web of Science ®Google Scholar
• Lund , E and Dahlberg , J E . 2006 . Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs . Cold Spring Harb Symp Quant Biol. , 71 : 59 – 66 .
   PubMedGoogle Scholar
• Maniataki , E and Mourelatos , Z . 2005 . A human, ATP-independent, RISC assembly machine fueled by pre-miRNA . Genes Dev. , 19 ( 24 ) : 2979 – 2990 .
   PubMed Web of Science ®Google Scholar
• Gregory , R I , Chendrimada , T P , Cooch , N and Shiekhattar , R . 2005 . Human RISC couples microRNA biogenesis and posttranscriptional gene silencing . Cell. , 123 ( 4 ) : 631 – 640 .
   PubMed Web of Science ®Google Scholar
• Meltzer , P S . 2005 . Cancer genomics: small RNAs with big impacts . Nature. , 435 ( 7043 ) : 745 – 746 .
   PubMed Web of Science ®Google Scholar
• Yekta , S , Shih , I H and Bartel , D P . 2004 . MicroRNA-directed cleavage of HOXB8 mRNA . Science. , 304 ( 5670 ) : 594 – 596 .
   PubMed Web of Science ®Google Scholar
• Hutvagner , G and Zamore , P D . 2002 . A microRNA in a multiple-turnover RNAi enzyme complex . Science. , 297 ( 5589 ) : 2056 – 2060 .
   PubMed Web of Science ®Google Scholar
• Meister , G and Tuschl , T . 2004 . Mechanisms of gene silencing by double-stranded RNA . Nature. , 431 ( 7006 ) : 343 – 349 .
   PubMed Web of Science ®Google Scholar
• Brennecke , J , Stark , A , Russell , R B and Cohen , S M . 2005 . Principles of microRNA-target recognition . PLoS Biol. , 3 ( 3 ) : e85
   PubMed Web of Science ®Google Scholar
• Lytle , J R , Yario , T A and Steitz , J A . 2007 . Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5’ UTR as in the 3’ UTR . Proc Natl Acad Sci U S A. , 104 ( 23 ) : 9667 – 9672 .
   PubMed Web of Science ®Google Scholar
• Duursma , A M , Kedde , M , Schrier , M , le Sage , C and Agami , R . 2008 . miR-148 targets human DNMT3b protein coding region . RNA. , 14 ( 5 ) : 872 – 877 .
   PubMed Web of Science ®Google Scholar
• Tay , Y , Zhang , J , Thomson , A M , Lim , B and Rigoutsos , I . 2008 . MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation . Nature. , 455 ( 7216 ) : 1124 – 1128 .
   PubMed Web of Science ®Google Scholar
• Lewis , B P , Shih , I H , Jones-Rhoades , M W , Bartel , D P and Burge , C B . 2003 . Prediction of mammalian microRNA targets . Cell. , 115 ( 7 ) : 787 – 798 .
   PubMed Web of Science ®Google Scholar
• Humphreys , D T , Westman , B J , Martin , D I and Preiss , T . 2005 . MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function . Proc Natl Acad Sci U S A. , 102 ( 47 ) : 16961 – 16966 .
   PubMedGoogle Scholar
• Petersen , C P , Bordeleau , M E , Pelletier , J and Sharp , P A . 2006 . Short RNAs repress translation after initiation in mammalian cells . Mol Cell. , 21 ( 4 ) : 533 – 542 .
   PubMed Web of Science ®Google Scholar
• Wu , L , Fan , J and Belasco , J G . 2006 . MicroRNAs direct rapid deadenylation of mRNA . Proc Natl Acad Sci U S A. , 103 ( 11 ) : 4034 – 4039 .
   PubMed Web of Science ®Google Scholar
• Brodersen , P and Voinnet , O . 2009 . Revisiting the principles of microRNA target recognition and mode of action . Nat Rev Mol Cell Biol. , 10 ( 2 ) : 141 – 148 .
   PubMed Web of Science ®Google Scholar
• Bushati , N and Cohen , S M . 2007 . microRNA functions . Annu Rev Cell Dev Biol. , 23 : 175 – 205 .
   PubMed Web of Science ®Google Scholar
• Kloosterman , W P and Plasterk , R H . 2006 . The diverse functions of microRNAs in animal development and disease . Dev Cell. , 11 ( 4 ) : 441 – 450 .
   PubMed Web of Science ®Google Scholar
• Lewis , B P , Burge , C B and Bartel , D P . 2005 . Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets . Cell. , 120 ( 1 ) : 15 – 20 .
   PubMed Web of Science ®Google Scholar
• Lim , L P , Lau , N C , Garrett-Engele , P , Grimson , A , Schelter , J M , Castle , J , Bartel , D P , Linsley , P S and Johnson , J M . 2005 . Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs . Nature. , 433 ( 7027 ) : 769 – 773 .
   PubMed Web of Science ®Google Scholar
• Brennecke , J , Hipfner , D R , Stark , A , Russell , R B and Cohen , S M . 2003 . bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila . Cell. , 113 ( 1 ) : 25 – 36 .
   PubMed Web of Science ®Google Scholar
• Xu , P , Vernooy , S Y , Guo , M and Hay , B A . 2003 . The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism . Curr Biol. , 13 ( 9 ) : 790 – 795 .
   PubMed Web of Science ®Google Scholar
• Stark , A , Brennecke , J , Russell , R B and Cohen , S M . 2003 . Identification of Drosophila MicroRNA targets . PLoS Biol. , 1 ( 3 ) : E60
   PubMed Web of Science ®Google Scholar
• Wightman , B , Ha , I and Ruvkun , G . 1993 . Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans . Cell. , 75 ( 5 ) : 855 – 862 .
   PubMed Web of Science ®Google Scholar
• Moss , E G , Lee , R C and Ambros , V . 1997 . The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA . Cell. , 88 ( 5 ) : 637 – 646 .
   PubMed Web of Science ®Google Scholar
• Lai , E C . 2002 . Micro RNAs are complementary to 3’ UTR sequence motifs that mediate negative post-transcriptional regulation . Nat Genet. , 30 ( 4 ) : 363 – 364 .
   PubMed Web of Science ®Google Scholar
• Shenouda , S K and Alahari , S K . 2009 . MicroRNA function in cancer: oncogene or a tumor suppressor? . Cancer Metastasis Rev. , 28 ( 3–4 ) : 369 – 378 .
   PubMed Web of Science ®Google Scholar
• Negrini , M , Nicoloso , M S and Calin , G A . 2009 . MicroRNAs and cancer–new paradigms in molecular oncology . Curr Opin Cell Biol. , 21 ( 3 ) : 470 – 479 .
   PubMed Web of Science ®Google Scholar
• Lee , Y S and Dutta , A . 2009 . MicroRNAs in cancer . Annu Rev Pathol. , 4 : 199 – 227 .
   PubMed Web of Science ®Google Scholar
• Iorio , M V and Croce , C M . 2009 . MicroRNAs in cancer: small molecules with a huge impact . J Clin Oncol. , 27 ( 34 ) : 5848 – 5856 .
   PubMed Web of Science ®Google Scholar
• Garzon , R , Calin , G A and Croce , C M . 2009 . MicroRNAs in Cancer . Annu Rev Med. , 60 : 167 – 179 .
   PubMed Web of Science ®Google Scholar
• Sassen , S , Miska , E A and Caldas , C . 2008 . MicroRNA: implications for cancer . Virchows Arch. , 452 ( 1 ) : 1 – 10 .
   PubMed Web of Science ®Google Scholar
• Manikandan , J , Aarthi , J J , Kumar , S D and Pushparaj , P N . 2008 . Oncomirs: The potential role of non-coding microRNAs in understanding cancer . Bioinformation. , 2 ( 8 ) : 330 – 334 .
   PubMedGoogle Scholar
• Chang , T C , Wentzel , E A , Kent , O A , Ramachandran , K , Mullendore , M , Lee , K H , Feldmann , G , Yamakuchi , M , Ferlito , M , Lowenstein , C J , Arking , D E , Beer , M A , Maitra , A and Mendell , J T . 2007 . Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis . Mol Cell. , 26 ( 5 ) : 745 – 752 .
   PubMed Web of Science ®Google Scholar
• Cole , K A , Attiyeh , E F , Mosse , Y P , Laquaglia , M J , Diskin , S J , Brodeur , G M and Maris , J M . 2008 . A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor Gene . Mol Cancer Res. , 6 ( 5 ) : 735 – 742 .
   PubMed Web of Science ®Google Scholar
• Tarasov , V , Jung , P , Verdoodt , B , Lodygin , D , Epanchintsev , A , Menssen , A , Meister , G and Hermeking , H . 2007 . Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest . Cell Cycle. , 6 ( 13 ) : 1586 – 1593 .
   PubMed Web of Science ®Google Scholar
• Raver-Shapira , N , Marciano , E , Meiri , E , Spector , Y , Rosenfeld , N , Moskovits , N , Bentwich , Z and Oren , M . 2007 . Transcriptional activation of miR-34a contributes to p53-mediated apoptosis . Mol Cell. , 26 ( 5 ) : 731 – 743 .
   PubMed Web of Science ®Google Scholar
• Subramanian , S , Thayanithy , V , West , R B , Lee , C H , Beck , A H , Zhu , S , Downs-Kelly , E , Montgomery , K , Goldblum , J R , Hogendoorn , P C , Corless , C L , Oliveira , A M , Dry , S M , Nielsen , T O , Rubin , B P , Fletcher , J A , Fletcher , C D and van de Rijn , M . 2010 . Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours . J Pathol. , 220 ( 1 ) : 58 – 70 .
   PubMed Web of Science ®Google Scholar
• Yamakuchi , M , Ferlito , M and Lowenstein , C J . 2008 . miR-34a repression of SIRT1 regulates apoptosis . Proc Natl Acad Sci U S A. , 105 ( 36 ) : 13421 – 13426 .
   PubMed Web of Science ®Google Scholar
• Welch , C , Chen , Y and Stallings , R L . 2007 . MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells . Oncogene. , 26 ( 34 ) : 5017 – 5022 .
   PubMed Web of Science ®Google Scholar
• He , L , He , X , Lim , L P , de Stanchina , E , Xuan , Z , Liang , Y , Xue , W , Zender , L , Magnus , J , Ridzon , D , Jackson , A L , Linsley , P S , Chen , C , Lowe , S W , Cleary , M A and Hannon , G J . 2007 . A microRNA component of the p53 tumour suppressor network . Nature. , 447 ( 7148 ) : 1130 – 1134 .
   PubMed Web of Science ®Google Scholar
• Tazawa , H , Tsuchiya , N , Izumiya , M and Nakagama , H . 2007 . Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells . Proc Natl Acad Sci U S A. , 104 ( 39 ) : 15472 – 15477 .
   PubMed Web of Science ®Google Scholar
• Hermeking , H . 2007 . p53 enters the microRNA world . Cancer Cell. , 12 ( 5 ) : 414 – 418 .
   PubMed Web of Science ®Google Scholar
• He , X , He , L and Hannon , G J . 2007 . The guardian's little helper: microRNAs in the p53 tumor suppressor network . Cancer Res. , 67 ( 23 ) : 11099 – 11101 .
   PubMedGoogle Scholar
• Sun , F , Fu , H , Liu , Q , Tie , Y , Zhu , J , Xing , R , Sun , Z and Zheng , X . 2008 . Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest . FEBS Lett. , 582 ( 10 ) : 1564 – 1568 .
   PubMed Web of Science ®Google Scholar
• Rokhlin , O W , Scheinker , V S , Taghiyev , A F , Bumcrot , D , Glover , R A and Cohen , M B . 2008 . MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer . Cancer Biol Ther. , 7 ( 8 ) : 1288 – 1296 .
   PubMed Web of Science ®Google Scholar
• Wei , J S , Song , Y K , Durinck , S , Chen , Q R , Cheuk , A T , Tsang , P , Zhang , Q , Thiele , C J , Slack , A , Shohet , J and Khan , J . 2008 . The MYCN oncogene is a direct target of miR-34a . Oncogene. , 27 ( 39 ) : 5204 – 5213 .
   PubMed Web of Science ®Google Scholar
• Lu , Z , Liu , M , Stribinskis , V , Klinge , C M , Ramos , K S , Colburn , N H and Li , Y . 2008 . MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene . Oncogene. , 27 ( 31 ) : 4373 – 4379 .
   PubMed Web of Science ®Google Scholar
• Zhu , S , Wu , H , Wu , F , Nie , D , Sheng , S and Mo , Y Y . 2008 . MicroRNA-21 targets tumor suppressor genes in invasion and metastasis . Cell Res. , 18 ( 3 ) : 350 – 359 .
   PubMed Web of Science ®Google Scholar
• Asangani , I A , Rasheed , S A , Nikolova , D A , Leupold , J H , Colburn , N H , Post , S and Allgayer , H . 2008 . MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer . Oncogene. , 27 ( 15 ) : 2128 – 2136 .
   PubMed Web of Science ®Google Scholar
• Corsten , M F , Miranda , R , Kasmieh , R , Krichevsky , A M , Weissleder , R and Shah , K . 2007 . MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas . Cancer Res. , 67 ( 19 ) : 8994 – 9000 .
   PubMed Web of Science ®Google Scholar
• Zhu , S , Si , M L , Wu , H and Mo , Y Y . 2007 . MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1) . J Biol Chem. , 282 ( 19 ) : 14328 – 14336 .
   PubMed Web of Science ®Google Scholar
• Si , M L , Zhu , S , Wu , H , Lu , Z , Wu , F and Mo , Y Y . 2007 . miR-21-mediated tumor growth . Oncogene. , 26 ( 19 ) : 2799 – 2803 .
   PubMed Web of Science ®Google Scholar
• Chan , J A , Krichevsky , A M and Kosik , K S . 2005 . MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells . Cancer Res. , 65 ( 14 ) : 6029 – 6033 .
   PubMed Web of Science ®Google Scholar
• Navarro , F , Gutman , D , Meire , E , Caceres , M , Rigoutsos , I , Bentwich , Z and Lieberman , J . 2009 . miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53 . Blood. , 114 ( 10 ) : 2181 – 2192 .
   PubMed Web of Science ®Google Scholar
• Chen , C Z . 2005 . MicroRNAs as oncogenes and tumor suppressors . N Engl J Med. , 353 ( 17 ) : 1768 – 1771 .
   PubMed Web of Science ®Google Scholar
• Cimmino , A , Calin , G A , Fabbri , M , Iorio , M V , Ferracin , M , Shimizu , M , Wojcik , S E , Aqeilan , R I , Zupo , S , Dono , M , Rassenti , L , Alder , H , Volinia , S , Liu , C G , Kipps , T J , Negrini , M and Croce , C M . 2005 . miR-15 and miR-16 induce apoptosis by targeting BCL2 . Proc Natl Acad Sci U S A. , 102 ( 39 ) : 13944 – 13949 .
   PubMed Web of Science ®Google Scholar
• Stearns , V and Gelmann , E P . 1998 . Does tamoxifen cause cancer in humans? . J Clin Oncol. , 16 ( 2 ) : 779 – 792 .
   PubMedGoogle Scholar
• Hard , G C , Williams , G M and Iatropoulos , M J . 1993 . Tamoxifen and liver cancer . Lancet. , 342 ( 8868 ) : 444 – 445 .
   PubMedGoogle Scholar
• Williams , G M , Iatropoulos , M J , Djordjevic , M V and Kaltenberg , O P . 1993 . The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat . Carcinogenesis. , 14 ( 2 ) : 315 – 317 .
   PubMedGoogle Scholar
• Osborne , M R , Hewer , A , Hardcastle , I R , Carmichael , P L and Phillips , D H . 1996 . Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen . Cancer Res. , 56 ( 1 ) : 66 – 71 .
   PubMedGoogle Scholar
• da Costa , G G , Manjanatha , M G , Marques , M M and Beland , F A . 2002 . Induction of lacI mutations in Big Blue rats treated with tamoxifen and alpha-hydroxytamoxifen . Cancer Lett. , 176 ( 1 ) : 37 – 45 .
   PubMedGoogle Scholar
• Davies , R , Oreffo , V I , Martin , E A , Festing , M F , White , I N , Smith , L L and Styles , J A . 1997 . Tamoxifen causes gene mutations in the livers of lambda/lacI transgenic rats . Cancer Res. , 57 ( 7 ) : 1288 – 1293 .
   PubMedGoogle Scholar
• Pogribny , I P , Muskhelishvili , L , Tryndyak , V P and Beland , F A . 2009 . The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation . Toxicol Appl Pharmacol. , 235 ( 3 ) : 305 – 311 .
   PubMed Web of Science ®Google Scholar
• Jalas , J R , Hecht , S S and Murphy , S E . 2005 . Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen . Chem Res Toxicol. , 18 ( 2 ) : 95 – 110 .
   PubMed Web of Science ®Google Scholar
• Little , J B . 2000 . Radiation carcinogenesis . Carcinogenesis. , 21 ( 3 ) : 397 – 404 .
   PubMed Web of Science ®Google Scholar
• Ilnytskyy , Y , Zemp , F J , Koturbash , I and Kovalchuk , O . 2008 . Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism . Biochem Biophys Res Commun. , 377 ( 1 ) : 41 – 45 .
   PubMed Web of Science ®Google Scholar
• Huang , J , Fan , T , Yan , Q , Zhu , H , Fox , S , Issaq , H J , Best , L , Gangi , L , Munroe , D and Muegge , K . 2004 . Lsh, an epigenetic guardian of repetitive elements . Nucleic Acids Res. , 32 ( 17 ) : 5019 – 5028 .
   PubMed Web of Science ®Google Scholar
• Raiche , J , Rodriguez-Juarez , R , Pogribny , I and Kovalchuk , O . 2004 . Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice . Biochem Biophys Res Commun. , 325 ( 1 ) : 39 – 47 .
   PubMed Web of Science ®Google Scholar
• Lukiw , W J and Pogue , A I . 2007 . Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells . J Inorg Biochem. , 101 ( 9 ) : 1265 – 1269 .
   PubMed Web of Science ®Google Scholar
• Lin , Y , Liu , X , Cheng , Y , Yang , J , Huo , Y and Zhang , C . 2009 . Involvement of MicroRNAs in hydrogen peroxide-mediated gene regulation and cellular injury response in vascular smooth muscle cells . J Biol Chem. , 284 ( 12 ) : 7903 – 7913 .
   PubMed Web of Science ®Google Scholar
• Cheng , Y , Liu , X , Zhang , S , Lin , Y , Yang , J and Zhang , C . 2009 . MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4 . J Mol Cell Cardiol. , 47 ( 1 ) : 5 – 14 .
   PubMed Web of Science ®Google Scholar
• Ross , J , Blackman , C , Thai , S , Li , Z , Kohan , M , Jones , C and Chen , T . 2010 . A potential microRNA signature for tumorigenic conazoles in mouse liver . Molecular Carcinogenesis. , 49 ( 4 ) : 320 – 323 .
   PubMed Web of Science ®Google Scholar
• Moffat , I D , Boutros , P C , Celius , T , Linden , J , Pohjanvirta , R and Okey , A B . 2007 . microRNAs in adult rodent liver are refractory to dioxin treatment . Toxicol Sci. , 99 ( 2 ) : 470 – 487 .
   PubMedGoogle Scholar
• Yager , J D and Davidson , N E . 2006 . Estrogen carcinogenesis in breast cancer . N Engl J Med. , 354 ( 3 ) : 270 – 282 .
   PubMed Web of Science ®Google Scholar
• Hsu , P Y , Deatherage , D E , Rodriguez , B A , Liyanarachchi , S , Weng , Y I , Zuo , T , Liu , J , Cheng , A S and Huang , T H . 2009 . Xenoestrogen-induced epigenetic repression of microRNA-9–3 in breast epithelial cells . Cancer Res. , 69 ( 14 ) : 5936 – 5945 .
   PubMed Web of Science ®Google Scholar
• Cheng , A S , Culhane , A C , Chan , M W , Venkataramu , C R , Ehrich , M , Nasir , A , Rodriguez , B A , Liu , J , Yan , P S , Quackenbush , J , Nephew , K P , Yeatman , T J and Huang , T H . 2008 . Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome . Cancer Res. , 68 ( 6 ) : 1786 – 1796 .
   PubMedGoogle Scholar
• Shields , P G . 1999 . Molecular epidemiology of lung cancer . Ann Oncol. , : S7 – 11 .
   Google Scholar
• Wistuba , I I , Lam , S , Behrens , C , Virmani , A K , Fong , K M , LeRiche , J , Samet , J M , Srivastava , S , Minna , J D and Gazdar , A F . 1997 . Molecular damage in the bronchial epithelium of current and former smokers . J Natl Cancer Inst. , 89 ( 18 ) : 1366 – 1373 .
   PubMedGoogle Scholar
• Schembri , F , Sridhar , S , Perdomo , C , Gustafson , A M , Zhang , X , Ergun , A , Lu , J , Liu , G , Bowers , J , Vaziri , C , Ott , K , Sensinger , K , Collins , J J , Brody , J S , Getts , R , Lenburg , M E and Spira , A . 2009 . MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium . Proc Natl Acad Sci U S A. , 106 ( 7 ) : 2319 – 2324 .
   PubMed Web of Science ®Google Scholar
• Izzotti , A , Calin , G A , Arrigo , P , Steele , V E , Croce , C M and De Flora , S . 2009 . Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke . FASEB J. , 23 ( 3 ) : 806 – 812 .
   PubMed Web of Science ®Google Scholar
• Izzotti , A , Calin , G A , Steele , V E , Cartiglia , C , Longobardi , M , Croce , C M and De Flora , S . 2010 . Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs . Cancer Prev Res (Phila Pa) , 3 ( 1 ) : 62 – 72 .
   PubMedGoogle Scholar
• Izzotti , A , Calin , G A , Steele , V E , Croce , C M and De Flora , S . 2009 . Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light . FASEB J. , 23 ( 9 ) : 3243 – 3250 .
   PubMed Web of Science ®Google Scholar
• Tinwell , H , Stephens , S C and Ashby , J . 1991 . Arsenite as the probable active species in the human carcinogenicity of arsenic: mouse micronucleus assays on Na and K arsenite, orpiment, and Fowler's solution . Environ Health Perspect. , 95 : 205 – 210 .
   PubMed Web of Science ®Google Scholar
• Maier , A , Schumann , B L , Chang , X , Talaska , G and Puga , A . 2002 . Arsenic co-exposure potentiates benzo[a]pyrene genotoxicity . Mutat Res. , 517 ( 1–2 ) : 101 – 111 .
   PubMedGoogle Scholar
• Li , J H and Rossman , T G . 1991 . Comutagenesis of sodium arsenite with ultraviolet radiation in Chinese hamster V79 cells . Biol Met. , 4 ( 4 ) : 197 – 200 .
   PubMedGoogle Scholar
• Li , J H and Rossman , T G . 1989 . Mechanism of comutagenesis of sodium arsenite with n-methyl-n-nitrosourea . Biol Trace Elem Res. , 21 : 373 – 381 .
   PubMed Web of Science ®Google Scholar
• Marsit , C J , Eddy , K and Kelsey , K T . 2006 . MicroRNA responses to cellular stress . Cancer Res. , 66 ( 22 ) : 10843 – 10848 .
   PubMed Web of Science ®Google Scholar
• Kasashima , K , Nakamura , Y and Kozu , T . 2004 . Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells . Biochem Biophys Res Commun. , 322 ( 2 ) : 403 – 410 .
   PubMed Web of Science ®Google Scholar
• Chen , A , Luo , M , Yuan , G , Yu , J , Deng , T , Zhang , L , Zhou , Y , Mitchelson , K and Cheng , J . 2008 . Complementary analysis of microRNA and mRNA expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of HL-60 cells . Biotechnol Lett. , 30 ( 12 ) : 2045 – 2052 .
   PubMedGoogle Scholar
• Shah , Y M , Morimura , K , Yang , Q , Tanabe , T , Takagi , M and Gonzalez , F J . 2007 . Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation . Mol Cell Biol. , 27 ( 12 ) : 4238 – 4247 .
   PubMedGoogle Scholar
• Davidson , L A , Wang , N , Shah , M S , Lupton , J R , Ivanov , I and Chapkin , R S . 2009 . n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon . Carcinogenesis. , 30 ( 12 ) : 2077 – 2084 .
   PubMedGoogle Scholar
• Burdick , A D , Ivnitski-Steele , I D , Lauer , F T and Burchiel , S W . 2006 . PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells . Carcinogenesis. , 27 ( 11 ) : 2331 – 2340 .
   PubMedGoogle Scholar
• Debernardi , S , Skoulakis , S , Molloy , G , Chaplin , T , Dixon-McIver , A and Young , B D . 2007 . MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis . Leukemia. , 21 ( 5 ) : 912 – 916 .
   PubMed Web of Science ®Google Scholar
• Bhat-Nakshatri , P , Wang , G , Collins , N R , Thomson , M J , Geistlinger , T R , Carroll , J S , Brown , M , Hammond , S , Srour , E F , Liu , Y and Nakshatri , H . 2009 . Estradiol-regulated microRNAs control estradiol response in breast cancer cells . Nucleic Acids Res. , 37 ( 14 ) : 4850 – 4861 .
   PubMed Web of Science ®Google Scholar