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Research Article

Transport of Chitosan Microparticles for Mucosal Vaccine Delivery in a Human Intestinal M-cell Model

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Pages 449-456 | Published online: 30 Sep 2008

  • Allaoui-Attarki, A., Fattal, E., Pecquet, S., Trolle, S., Chachaty, E., Couvreur, P. and Andremont, A. (1998) "Mucosal immunogenicity elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly (D,L -lactide-co-glycolide) microspheres". Vaccine 16, 685-691.
  • Alpar, H.O., Eyles, J and Williamson, E. (1998) "Oral and nasal immunization with microencapsulated clinically relevant proteins". S.T.P. Pharma Sci. 8, 31-39.
  • Artursson, P. and Borchardt, R.T. (1997) "Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond". Pharm. Res. 12, 1655-1658.
  • Barackman, J.D., Singh, M., Ugozolli, M., Ott, G.S. and O'Hagan, D.T. (1998) "Oral immunization with poly(lactide-co-glycolide) microparticles containing an entrapped recombinant glycoprotein (gD2) from Herpes simplex type 2 virus". S.T.P. Pharma Sci. 8, 41-46.
  • Eldridge, J.H., Hammond, C.J., Meulbroek, J.A., Staas, J.K., Gilley, R.M. and Rice, T.R. (1990) "Controlled vaccine release in the gut associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer's patches". J. Control. ReI. 11, 205-214.
  • Gullberg, E., Leonard, M., Karlsson, J., Hopkins, A.M., Brayden, D., Baird, W. and Anursson, P. (2000) "Expression of specific markers and particle transport in a new human intestinal M-cell model". Biochem. Biophys. Res. Commun. 279, 803-813.
  • Hidalgo, LJ., Raub, T.J. and Borchardt, R.T. (1989) "Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability". Gastroenterology 96, 736-749.
  • Jones, B.D., Ghori, N. and Falkow, S. (1994) "Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches". J. Exp. Med. 180, 7-9.
  • Kernéis, S., Bogdonova, A., Kraehenbuhl, J.-P and Pringault, E. (1997) "Conversion by Peyer's patches lymphocytes of human enterocytes into M cells that transport bacteria". Science 277, 949-952.
  • Kotzé, A.F., Luessen, H.L., De Boer, A.G., Verhoef, J.C. and Junginger, H.E. (1998) "Chitosan for enhanced intestinal permeability: prospects for derivatives soluble in neutral and basic environment". FMI: J. Pharm. Sci. 7, 145-151.
  • Lydyard, P and Grossi, C. (1998) 'The lymphoid system". In: Roitt, I., Brostoff, J. and Male, D., eds. Immunology (Mosby, London), pp. 31-42.
  • Owen, R.I. and Jones, A.L. (1974) "Epithelial specialization within human Peyer's patches: an ultrastructual study of intestinal lymphoid follicles". Gastroenterology 66, 189-203.
  • Reseigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.P. and RicciardiCastagnoli, P. (2001) "Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria". Nature lmmunol. 2(4), 361-367.
  • Rusell Jones, G. (2000) "Oral vaccine delivery". J. Control. Rel. 65, 49-54.
  • Van der Lubben, I.M., Verhoef, J.C., Van Aelst, A., Borchard, G. and Junginger, H.E. (2001a) "Chitosan microparticles for oralvaccination: preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches". Biomaterials 22, 687-694.
  • Van der Lubben, I.M., Konings, F.A.J., Borchard, G., Verhoef, J.C. and Junginger, H.E. (2001b) "In vivo uptake of chitosan microparticles by murine Peryer's patches: visualization studies using confocal laser scanning microscopy and immunohistochemistry". J. Drug Target. 9, 39-47.
  • Van der Lubben, I.M., Kersten, G., Beuvery, C. Verhoef, J.C., Junginger, H.E. "Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice". Vaccine, in press.

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