Advanced search
Publication Cover
Journal of Drug Targeting Volume 10, 2002 - Issue 8
Submit an article Journal homepage
100
Views
67
CrossRef citations to date
0
Altmetric
Research Article

In Vitro Antileishmanial Activity of Amphotericin B Loaded in Poly(ε-Caprolactone) Nanospheres

M.S. Espuelas Centro Galénico, Facultad de Farmacia, Universidad de Navarra, Pamplona, 31080 Spain
,
P. Legrand UMR 8612, Faculté de Pharmacie, Université Paris-Sud, 5 av. J-B. Clément, Châtenay-Malabry, 92296 France
,
P.M. Loiseau Biologie et Contrôle des Organismes Parasites, UPRES-EA 398 Faculté de Pharmacie, Université de Paris-Sud, Châtenay-Malabry, France
,
C. Bories Biologie et Contrôle des Organismes Parasites, UPRES-EA 398 Faculté de Pharmacie, Université de Paris-Sud, Châtenay-Malabry, France
,
G. Barratt UMR 8612, Faculté de Pharmacie, Université Paris-Sud, 5 av. J-B. Clément, Châtenay-Malabry, 92296 France
&
J.M. Irache Centro Galénico, Facultad de Farmacia, Universidad de Navarra, Pamplona, 31080 Spain
Pages 593-599 | Published online: 30 Sep 2008

  • Alvar, J., Caüavate, C, Gutierrez-Solar, B., Jimenez, M., Laguna, P., Lopez-Velez, R., Molina, R. and Moreno, J. (1997) "Leishmania and human immunodeficiency virus coinfection: the first 10 years", Clin. Micmbiol. Rev 10, 298-319.
  • Alving, C.R. (1988) "Macrophages as target for delivery of liposomes encapsulated antimicrobial agents". Adv. Drug Del. Rat. 2, 107-128.
  • Herman, J.D., Ksionski, G., Chapman, W.L., Waits, V.B. and Hanson, W.L. (1992) "Activity of amphotericin B cholesterol dispersion (Amphocil®) in experimental visceral leishmaniasis", Antimicrob. Agents Chemother. 36, 1978-1980.
  • Bolard, J., Joly, V. and Yeni, P. (1993) "Mechanism of action of amphotericin B at the cellular level. Its modulation by delivery systems", J. Liposome Res. 3, 409-427.
  • Caio Torres-Santos, E., Rodriguez, Jr., J.M., Moreira, D.L., Kaplan, M.A.C. and Rossi-Bergmann, B. (1999) "Improvement of in vitro and in vivo antileishmanial activities of 2',6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles", Antimicrob. Agents Chemother. 43, 1776-1778.
  • Cauchetier, E., Paul, M., Rivollet, D., Fessi, H., Astier, A. and Deniau, M. (2000) "Therapeutic evaluation of free and liposome-encapsulated atovaquone in the treatment of marine leishmaniasis". Int. J. Parasitai. 30, 777-783.
  • Croft, S.L., Davidson, R.N. and Thomton, E.A. (1991) "Uposomal amphotericin B in the treatment of visceral leishmaniasis", J. Antimicrob. Chemother. 28(B), 111-118.
  • Davidson, R.N., Croft, S.L., Scott, A., Main, M, Moody, A.H. and Bryceson, A.D.M. (1991) "Liposomal amphotericin B in drugresistant visceral leismaniasis", Clin. Infect. Dis. 22, 1-11.
  • Durand, R., Paul, M., Rivollet, D., Houin, R., Astier, A. and Deniau, M. (1997) "Activity of pentamidine-loaded methacrylate nanoparticles against Leishmania infantum in a mouse model". Int. J. Parasitai 27, 1361-1367.
  • Espuelas, M.S., Legrand, P., Irache, J.M., Gamazo, C, Orecchioni, A.M., Devissaguet, J.-Ph. and Ygartua, P. (1997) "Polyfe-caprolactone) nanospheres as an alternative way to reduce amphotericin B toxicity", Int. J. Pharm. 158, 19-279.
  • Espuelas, M.S., Legrand, P., Cheron, M., Barratt, G., Puisieux, P., Devissaguet, J-P. and Irache, J.M. (1998) 'Interaction of amphotericn B with polymeric colloids: 2. Effect of poloxamer 188 on the adsorption of amphotericin B onto poly (e-caprolactone) nanospheres". Colloids Surf. B11, 203-212.
  • Espuelas, S., Legrand, P., Loiseau, P.M., Bones, C., Barrat, G. and Irache, J.M. (2000) "In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188", Antimicrob. Agents Chemother. 44, 2190-2192.
  • Frezard, P., Michalick, M.S., Soares, CF. and Demicheli, C. (2000) "Novel methods for the encapsulation of meglumine antimoniate into liposomes", BFBZ. J. Med. Biol. Res. 33, 841-846.
  • Caspar, R., Preat, V, Opperdoes, RR. and Roland, M. (1992) "Macrophage activation by polymeric nanoparticles of polyalkylcyanoacrylates: activity against intracellular Leishmania donovani associated with hydrogen peroxide production", Pharm. Res. 9, 782-787.
  • Hammoda, N.A., Negm, A.Y., Hussein, E.D., el Temsahy, M.M. and Rashwan, E.A. (1996) "Leishmania major, leishmanicidal activity of activated macrophages by interferon gamma or tumour necrosis factor", J. Egypt Soc. Parasitai 26, 555-566.
  • Herwaldt, B.L. (1999) "Leishmaniasis", Lancet 354, 1191-1199.
  • Larabi, M, Legrand, P., Appel, M., Gil, S., Lepoivre, M., Devissaguet, J-R, Puiseaux, F. and Barratt, G. (2001) "Reduction of NO synthase expression and tumor necrosis factor alpha production in macrophages by amphotericin B lipid carriers", Antimicrob. Agents Chanother. 45, 553-562.
  • Legrand, P., Vertut-Doi, A. and Bolard, J. (1996) "Comparative intemalization and recycling of different amphotericin B formulations by a macrophage-like cell line", J. Antimicrob. Chemother. 37, 519-533.
  • Mbongo, N., Loiseau, P.M., Billion, M.A. and Robert-Gero, M. (1998) "Mechanism of amphotericin B resistance in Leishmania donovani promastigotes", Antimicrob. Agents Chemother. 42, 352-357.
  • Meyerhoff, A. (1999) "US Food and Drug administration approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis", Clin. Infect. Dis. 28, 49-51.
  • Mozaffarian, N., Berman, J.W. and Casadevall, A. (1997) "Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B", Antimicrob. Agents Chemother. 41, 1825-1829.
  • Müllen, A.B., Carter, K.C. and Bafflie, A.J. (1997) "Comparison of the efficacies of various formulations of amphotericin B against marine visceral leishmaniasis", Antimicrob. Agents Chemother. 41, 2089-2092.
  • Murray, H.W. (1999) "Kala-azar as an AIDS related opportunistic infection". Aids Patient care STDS13, 459-465.
  • Newman, MJ., Actor, J.K., Balussuhramanian, M. and Jagannath, C. (1998) "Use of nonionic block copolymers in vaccines and therapeutics", CnY. Reu Ther. Drug Carrier Syst. 15, 89-142.
  • Paul, M., Durand, R., Fessi, H., Rivollet, D., Houin, R., Astier, A. and Deniau, M. (1997) "Activity of a new liposomal formulation of amphotericin B against two strains of Leishmania infantum in a mutine model", Antimicrob. Agents Chemother. 41, 1731-1734.
  • Pearson, R.D. and Sousa, A.D. (1996) "Clinical spectrum of Leishmaniasis", Clin. Infect. Dis. 22, 1-11.
  • Rodriguez, J.M., Croft, S.L., Fessi, H., Bories, C. and Devissaguet, J.-P. (1994) "The activity and ultrastnictural localization of primaquineloaded poly (D,L-lactide) nanoparticles in Leishmania donovani infected mice". Trop. Med. Parasitai 45, 223-228.
  • Sereno, D., Holzmuller, P. and Lemesre, J.L. (2000) "Efficacy of second line drugs on antimonyl-resistant amastigotes of Leishmania infantum", Acta Tropica, 25-31.
  • Vernier-Julienne, M.C., Vouldoukis, I., Monjour, L. and Benoit, J.P. (1995) "In vitro study of me anti-leishmanial activity of biodegradable nanoparticles", J Drug Targeting 3, 23-29.
  • Yardley, V. and Croft, S.L. (1997) "Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis", Antimicrob. Agents Chemother. 41, 752-756.
  • Yardley, V. and Croft, S.L. (2000) "A comparison of the activities of three amphotericin B lipid formulations against experimental visceral and cutaneous leishmaniasis". Int. J. Antimicrob. Agents 13, 243-248.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.