Advanced search
Publication Cover
Journal of Drug Targeting Volume 10, 2002 - Issue 8
Submit an article Journal homepage
60
Views
9
CrossRef citations to date
0
Altmetric
Research Article

An In-vitro Evaluation of Lectin Cytotoxicity using Cell Lines Derived from the Ocular Surface

C. Banchonglikitkul School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DZ UK
,
J.D. Smart School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DZ UK
,
R.V. Gibbs School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DZ UK
,
S.J. Donovan School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DZ UK
&
D.J. Cook School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DZ UK
Pages 601-606 | Published online: 30 Sep 2008

  • Araki-Sasaki, P., Ohashi, Y., Sasabe, T., Hayashi, K., Watanabe, H., Tano, Y. and Handa, H. (1995) "An SV40-immortalized human corneal epithelial cell line and its characterization", Invest. Ophthalmol. Vis. Sci. 36, 614-621.
  • Banchonglikitfcul, C, Smart, J.D., Gibbs, R.V. and Code, DJ. (2000) "The binding of some Diocleae lectins to the mucosal surfaces of the eye and mouth", Br. J. Blamed. Sci. 57, 7-12.
  • Banwell, J.G., Boldt, D.H., Meyers, J., Weber, F.L., Miller, B. and Howard, R. (1983) "Phytohaemagglutinin derived from red kidney bean (Phaseolus vulgaris): a cause for intestinal malabsorption associated with bacterial overgrowth in the rat", Gastroenterology 84, 506-515.
  • Büing, A. and Schietzel, M. (1999) "Apoptosis-inducing properties of Viscum album L. extracts from different host trees, correlate with their content of toxic Mistletoe lectins", Anticancer Res. 19, 23-28.
  • Calderone, R. and Wadsworth, E. (1993) "Adherence molecules of Candida albicans", J. Microbiol. Methods 18, 197-211.
  • Ferreira, R.R., Cavada, B.S., Moreira, R.A., Oliviera, J.T.A. and Gomes, J.C. (1996) 'Characteristics of the histamine release from hamster cheek pouch mast cells stimulated by lectins from Brazilian beans and Concanavalin A", Inflamm. Res. 45, 442-447.
  • Goldhare, J. (1994) "Bacterial lectin-like adhesins: determination and specificity". In: Clark, V.L. and Bavoil, P.M., eds, Bacterial Pathogenesis, Pt B (Academic Press, San Diego), pp. 211-231.
  • Irache, J.M., Durrer, C, Duchene, D. and Ponchel, G. (1994) "In-vitm study of lectin-latex conjugates for specific bioadhesion", J. Control. Release 31, 181-188.
  • Kim, M., Rao, V., Iweardy, D., Prakash, M., Galili, U. and Gorelik, E. (1993) 'Pectin-induce apoptosis of tumor cells", Glycobiology 3, 447-453.
  • Kompella, U.B. and Lee, V.H.L. (1992) "Means to enhance penetration. 4. Delivery systems for the enhancement of peptide and protein drugs: design considerations". Adv. Drug Delhi. Rev. 8, 115-162.
  • Kulkarni, G.V. and McCulloch, C.A.G. (1995) "Concanavalin A induced apoptosis in fihtoblasts: the role of cell surface carbohydrates in lectin mediated cytotoxicity", J. Cell Physiol 165, 119-133.
  • Lee, J.W., Park, J.H. and Robinson, J.R. (2000) "Bioadhesive-based dosage forms: the next generation", J Pharm. Sci. 89, 850-866.
  • Lehr, C-M. (2000) "Lectin-mediated drug delivery: the second generation of bioadhesives", J. Control Release 65, 19-29.
  • Lehr, C-M. and Lee, V.H.L. (1993) "Binding and transport of some bioadhesive plant lectins across Caco-2 cell monolayers", Pharm. Res. 10, 1796-1799.
  • Liener, I.E. (1997) "Plant lectins, properties nutritional significance and function". In: Shahidi, P., ed, Antinutrients and Phytochemicals in Food. ACS Symposium Series (American Chemical Society, Washington DC), pp. 31-44.
  • Lorea, P., Goldschmidt, D., Darro, F., Salmon, L, Bovin, N., Gabius, R-J., Kiss, R. and Danguy, A. (1997) "In-vitm characterisation of lectin-induced alterations on the proliferative activity of three human melanoma cell lines". Melanoma Res. 7, 353-363.
  • Makela, O. (1957) "Studies in heamagglutinins of leguminosae seeds", Ann. Med. Exp. Biol Fenn. 35(Suppl. 11).
  • Mockel, B., Schwarz, T., Zinke, H., Eck, J., Langer, M. and Lentzen, H. (1997) "Effects of Mistletoe lectin I on human blood cell lines and peripheral blood cells". Drug Res. 47, 1145-1151.
  • Naisbett, B. and Woodley, J. (1995a) "The potential for tomato lectin for oral drug delivery: 3. Bioadhesion in-vivo". Int. J. Pharm. 114, 227-236.
  • Naisbett, B. and Woodley, J. (199Sb) 'The potential of tomato lectin for oral drug delivery: 4. Immunological consequences". Int. J. Pharm. 120, 247-254.
  • Nantwi,' P.K.K., Cook, DJ., Rogers, DJ. and Smart, J.D. (1997) "Lectins for drug delivery within the oral cavity-investigation of lectin binding to oral mucosa", J. Drug Target. 5, 45-55.
  • Nicholls, T.J., Green, K.L., Cook, D.J., Rogers, D.J., Wolowacz, S. and Smart, J.D. (1996a) "Lectins in ocular drug delivery: an investigation of lectin binding sites on the comeal and conjunctival surfaces", Int. J. Pharm. 138, 175-183.
  • Nicholls, T.J., Cook, D.J., Rogers, D. J., Green, K.L. and Smart, J.D. (1997) "Lectins in ocular drug del ivery-an in-vivo study of lectin retention on ocular surfaces", Pharm. Sci. 3, 1-5.
  • Pustai, A., Ewen, S.W.B., Grant, G., Peumans, W.J., Van Damme, E.J.M., Coates, M.E. and Bardocz, S. (1995) "Lectins and also bacteria modify glycosylation of gut surface receptors in the rat", Glycoconj. J. 12, 22-35.
  • Ribereau-Gayon, G., Jung, M.L., Beck, J.P. and Anton, R. (1995) "Effect of fetal calf serum on the cytotaxic activity of Mistletoe (Viscum album L.) lectins in cell culture", Phytother. Res. 9, 336-339.
  • Rudner, X.L., Zheng, Z., Berk, R.S., Iran, R.T. and Hazlett, L.D. (1992) "Comeal epithelial glycoproteins exhibit Pseudomonas Aeroginosa pilus binding activity". Invest. Ophthamol. Vis. Sci 33, 2185-2193.
  • Sandin, R.L., Ogers, A.L., Patterson, R.L. and Beneke, E.S. (1982) "Evidence for mannose mediated adherence of Candida albicans to human buccal cells in-vitm". Inject. Immun. 35, 79-85.
  • Saarinen-Savolainen, P., Järvinen, T, Araki-Sasaki, K., Watanabe, H. and Urtti, A. (1998) "Evaluation of cytotoxicity of various ophthalmic drugs, eyedrop excipients and cyclodextrins in an immortalised human comeal epithelial cell line", Pharm. Res. 15, 1275-1280.
  • Shier, WT. (1979) "Lectins as drug carriers". In: Gregoriadis, G., ed, Drug Carriers in Biology and Medicine (Academic Press, London), pp. 43-70.
  • Sharon, N. (1993) "Lectin-carbohydrate complexes of plants and animals: an atomic view", TIBS 18, 221-226.
  • Smart, J.D., Nicholls, T.J., Green, K.L., Rogers, D.J. and Cook, J.D. (1999) "Lectins in drug delivery: a study of the acute local irritancy of the lectins from Solatium tuberosum and Helix pomatia", Eur. J. Pharm. Sci. 9, 93-98.
  • Zanetta, JP., Kuchler, S., Lehmann, S., Badache, A., Maschke, S., Thomas, D., Dufourcq, P. and Vincendon, G. (1992) "Glycoproteins and lectins in cell adhesion and cell recognition processes", Histochem. J. 24, 791-804.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.