In vitro and in vivo evaluation of pectin beads for the colon delivery of β-lactamases

References

• Adkin DA, Davis SS, Sparrow RA, Wilding IR. Colonic transit of different sized tablets in healthy subjects. J Control Rel 1993; 23: 147–156
   Web of Science ®Google Scholar
• Andremont A. Consequences of antibiotic therapy to the intestinal ecosystem. Ann Fr Anesth Reanim 2000; 19: 395–402
   PubMed Web of Science ®Google Scholar
• Arvidsson A, Gunnar A, Angelin B, Borga O, Nord CE. Ceftriaxone: Renal and biliary excretion and effect on colon microflora. J Antimicrob Chemother 1982; 10: 207–215
   PubMed Web of Science ®Google Scholar
• Bartlett JG, Chang TW, Gurwith M, Gorbach SL, Onderdonk AB. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med 1978; 298: 531–534
   PubMed Web of Science ®Google Scholar
• Batt RM. Enteric bacteria: Friend or Foe ?. J Small Anim Pract 1996; 37: 261–267
   PubMed Web of Science ®Google Scholar
• Batycky RP, Hanes J, Langer R, Edwards DA. A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. J Pharm Sci 1997; 86: 1464–1477
   PubMed Web of Science ®Google Scholar
• Bourgeois S, Fattal E, Andremont A, Couvreur P. Forme galénique pour la délivrance colique de principes actifs. 2003, PCT/FR03/02474
   Google Scholar
• Chachaty E, Depitre C, Mario N, Bourneix C, Saulnier P, Corthier G, Andremont A. Presence of Clostridium difficile and antibiotic and b-lactamase activities in feces of volunteers treated with oral cefixime, oral cefpodoxime proxetil, or placebo. Antimicrob Agents Chemother 1992; 36: 2009–2013
   PubMed Web of Science ®Google Scholar
• Chachaty E, Bourneix C, Renard S, Bonnay M, Andremont A. Shedding of Clostridium difficile, fecal b-lactamase activity, and gastrointestinal symptoms in 51 volunteers treated with oral cefixime. Antimicrob Agents Chemother 1993; 37: 1432–1435
   PubMed Web of Science ®Google Scholar
• Corpet DE. Antibiotic residues and drug resistance in human intestinal flora. Antimicrob Agents Chemother 1987; 31: 587–593
   PubMed Web of Science ®Google Scholar
• Edlund C, Stark C, Nord CE. The relationship between an increase in b-lactamase activity after oral administration of three new cephalosporins and protection against intestinal ecological disturbances. J Antimicrob Chemother 1994; 34: 127–138
   PubMed Web of Science ®Google Scholar
• El-Gibaly I. Oral delayed-release system based on Zn-pectinate gel (ZPG) microparticles as an alternative carrier to calcium pectinate beads for colonic drug delivery. Int J Pharm 2002; 232: 199–211
   PubMed Web of Science ®Google Scholar
• Gorbach SL. Intestinal microflora. Gastroenterology 1971; 60: 1110–1129
   PubMed Web of Science ®Google Scholar
• Harmoinen J, Vaali K, Koski P, Syrjanen K, Laitinen O, Lindevall K, Westermarck E. Enzymic degradation of a beta-lactam antibiotic, ampicillin, in the gut: A novel treatment modality. J Antimicrob Chemother 2003; 51: 361–365
   PubMed Web of Science ®Google Scholar
• Harmoinen J, Mentula S, Heikkila M, van der Rest M, Rajala-Schultz PJ, Donskey CJ, Frias R, Koski P, Wickstrand N, et al. Orally administered targeted recombinant Beta-lactamase prevents ampicillin-induced selective pressure on the gut microbiota: A novel approach to reducing antimicrobial resistance. Antimicrob Agents Chemother 2004; 48: 75–79
   PubMed Web of Science ®Google Scholar
• Hill MJ, Drasar BS. The normal colonic bacterial flora. Gut 1975; 16: 318–323
   PubMed Web of Science ®Google Scholar
• Hovgaard L, Brondsted H. Current applications of polysaccharides in colon targeting. Crit Rev Ther Drug Carrier Syst 1996; 13: 185–223
   PubMed Web of Science ®Google Scholar
• Kim TH, Park YH, Kim KJ, Cho CS. Release of albumin from chitosan-coated pectin beads in vitro. Int J Pharm 2003; 250: 371–383
   PubMed Web of Science ®Google Scholar
• Leonard F, Andremont A, Leclerq B, Labia R, Tancrede C. Use of beta-lactamase-producing anaerobes to prevent ceftriaxone from degrading intestinal resistance to colonization. J Infect Dis 1989; 160: 274–280
   PubMed Web of Science ®Google Scholar
• Liu P, Krishnan TR. Alginate-pectin-poly-l-lysine particulate as a potential controlled release formulation. J Pharm Pharmacol 1999; 51: 141–149
   PubMed Web of Science ®Google Scholar
• Morris ER, Powell DA, Gidley MJ, Rees DA. Conformations and interactions of pectins. I. Polymorphism between gel and solid states of calcium polygalacturonate. J Mol Biol 1982; 155: 507–516
   PubMed Web of Science ®Google Scholar
• Musabayane CT, Munjeri O, Bwititi P, Osim EE. Orally administered, insulin-loaded amidated pectin hydrogel beads sustain plasma concentrations of insulin in streptozotocin-diabetic rats. J Endocrinol 2000; 164: 1–6
   PubMed Web of Science ®Google Scholar
• Nord CE, Edlund C. Impact of antimicrobial agents on human intestinal microflora. J Chemother 1990; 2: 218–237
   PubMed Web of Science ®Google Scholar
• Nord CE, Edlund C. Ecological effects of antimicrobial agents on the human intestinal microflora. Microb Ecol Health Dis 1991; 4: 193–207
   Google Scholar
• Pires de Abreu LR, Ortiz RM, de Castro SC, Pedrazzoli J, Jr., Pires de Abreu LR, Ortiz RM, de Castro J, Jr. HPLC determination of amoxicillin comparative bioavailability in healthy volunteers after a single dose administration. J Pharm Pharm Sci 2003; 6: 223–230
   PubMed Web of Science ®Google Scholar
• Plaschina IG, Braudo EE, Tolstoguzov VB. Circular-dichroism studies of pectin solutions. Carbohydr Res 1978; 60: 1–8
   Web of Science ®Google Scholar
• Rubinstein A, Radai R. In vitro and in vivo analysis of colon specificity of calcium pectinate formulations. Eur J Pharm Sci 1995; 41: 291–295
   Google Scholar
• Semde R, Amighi K, Devleeschouwer MJ, Moes AJ. Effect of pectinolytic enzymes on the theophylline release from pellets coated with water insoluble polymers containing pectin HM or calcium pectinate. Int J Pharm 2000; 197: 169–179
   PubMed Web of Science ®Google Scholar
• Sinha VR, Kumria R. Microbially triggered drug delivery to the colon. Eur J Pharm Sci 2003; 18: 3–18
   PubMed Web of Science ®Google Scholar
• Sriamornsak P. Investigation on pectin as a carrier for oral delivery of proteins using calcium pectinate gel beads. Int J Pharm 1998; 169: 213–220
   Web of Science ®Google Scholar
• Sriamornsak P. Effect of calcium concentration, hardening agent and drying condition on release characteristics of oral proteins from calcium pectinate gel beads. Eur J Pharm Sci 1999; 8: 221–227
   PubMed Web of Science ®Google Scholar
• Stark C, Edlund C, Hedberg M, Nord CE. Induction of beta-lactamase production in the anaerobic microflora by cefoxitin. Clin Infect Dis 1995; 20: S350–S351
   PubMed Web of Science ®Google Scholar
• Stiefel U, Pultz NJ, Harmoinen J, Koski P, Lindevall K, Helfand MS, Donskey CJ. Oral administration of beta-lactamase preserves colonization resistance of piperacillin-treated mice. J Infect Dis 2003; 188: 1605–1609
   PubMed Web of Science ®Google Scholar
• Tancrède C, Andremont A, Labia R, Léonard F. Composition pharmaceutique administrable par voie orale, destinée à réduire les effets des b-lactamines sur la flore intestinale. 1988, WO8807865
   Google Scholar
• Thakur BR, Singh RK, Handa AK. Chemistry and uses of pectin/A review. Crit Rev Food Sci Nutr 1997; 37: 47–73
   PubMed Web of Science ®Google Scholar
• Van der Waaij D. History of recognition and measurement of colonization resistance of digestive tract as an introduction to selective gastrointestinal decontamination. Epidemiol Infect 1992; 109: 315–326
   PubMed Web of Science ®Google Scholar
• Van der Waaij D, Nord CE. Development and persistence of multi-resistance to antibiotics in bacteria; an analysis and a new approach to this urgent problem. Int J Antimicrob Agents 2000; 16: 191–197
   PubMed Web of Science ®Google Scholar
• Zhong H-J, Williams MAK, Keenan RD, Goodall DM, Rolin C. Separation and quantification of pectins using capillary electrophoresis: A preliminary study. Carbohyd Polym 1997; 32: 27–32
   Web of Science ®Google Scholar