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Research Article

Rectal and vaginal administration of insulin–chitosan formulations: An experimental study in rabbits

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Pages 563-572 | Received 18 Jul 2005, Accepted 24 Oct 2005, Published online: 08 Oct 2008

References

  • Acartürk F. Preparation of a prolonged-release tablet formulation of diclofenac sodium. Part 1: Using chitosan. Die Pharmazie 1989; 44: 547–549
  • Acartürk F, Şencan A, Çelebi N. Evaluation of the effect of low molecular chitosan on the solubility and dissolution characteristics of spirinolactone. Die Pharmazie 1993a; 48: 605–608
  • Acartürk F, Şencan A, Çelebi N. Enhancement of the dissolution of spirinolactone with chitosan and low-molecular weight gelatin. STP Pharma Sci 1993b; 3: 369–373
  • Ahsan F, Arnold JJ, Yang T, Meezan E, Schwiebert EM, Pillion DJ. Effects of the permeability enhancers, tetradecylmaltoside and dimethyl-β-cyclodextrin, on insulin movement across human bronchial epithelial cells (16HBE14o− ). Eur J Pharm Sci 2003; 20: 27–34
  • Akbuğa J, Durmaz G. Preparation and evaluation of cross-linked chitosan microspheres containing furosemide. Int J Pharm 1994; 111: 217–222
  • Artursson P, Lindmark T, Davis SS, Illum L. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm Res 1994; 11: 1358–1361
  • Aungst BJ, Rogers NJ, Shefter E. Comparison of nasal, rectal, buccal sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promoter. J Pharmacol Exp Ther 1988; 244: 23–27
  • Banga AK, Chien YW. Systemic delivery of therapeutic peptides and proteins. Int J Pharm 1988; 48: 15–50
  • Brange J, Langkjaer L. Insulin formulation and delivery. Protein delivery: Physical systems, Hendren Sanders. Plenium Press, New York 1997; 343–411
  • Borchard G, Lueßen HL, De Boer AG, Verhoef JC, Lehr C, Junginger HE. The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption III. Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J Control Rel 1996; 39: 131–138
  • Caldwell L, Nishihata T, Rytting JH, Higuchi T. Lymphatic uptake of water soluble drugs after rectal administration. J Pharm Pharmacol 1982; 34: 520–522
  • Degim IT, Acartürk F, Erdogan D, Demirez Lortlar N. Transdermal Administration of Bromocriptine. Biol Pharm Bull 2003; 26: 501–505
  • Dodane V, Amin Khan A, Mervin JR. Effect of chitosan on epithelial permeability and structure. Int J Pharm 1999; 182: 21–32
  • Dotsikas Y, Loukas YL. Kinetic degradation study of insulin complexed with methyl-beta cyclodextrin. Confirmation of complexation with electrospray mass spectrometry and 1 H NMR. J Pharm Biomed Anal 2002; 29: 487–494
  • Francis SA, Kelly JM, McCormack J, Rogers RA, Lai J, Schnecberger EE, Lynch RD. Rapid reduction of MDCK cell cholesterol by methyl-β-cyclodextrin alters steady state transepithelial electirical resistance. Eur J Cell Biol 1999; 78: 473–484
  • Heinemann L, Pfützner A, Heise T. Alternative routes of administration as an approach to improve insulin therapy: Update on dermal, oral, nasal and pulmonary insulin delivery. Curr Pharm Des 2001; 7: 1127–1351
  • Hovgaard L, Brondsted H, Nielsen HM. Drug delivery studies in caco-2 monolayers II. Absorption enhancer effects of lysophosphatdylcholines. Int J Pharm 1995; 114: 141–149
  • Hinchcliffe M, Illum L. Intranasal insulin delivery and therapy. Adv Drug Deliv Rev 1999; 35: 199–234
  • Hui-Bi X, Kai-Xun H, Yu-Shan Z, Qiu-Hua G, Qing-Zhi W, Wei-Qun T, Xi-Qun S, Ze-Xian C, Zhong-Hong G. Hypoglycaemic effect of a novel insulin buccal formulation on rabbits. Pharmacol Res 2002; 46: 459–467
  • Illum L, Davis SS. Intranasal insulin: Clinical pharmacokinetics. Clin Pharm 1992; 23: 30–41
  • Ishihara M, Ono K, Sato M, Nakanishi K, Saito Y, Yura H, Matsui T, Hattori H, Fujita M, Kikuchi M, Kurita A. Acceleration of wound contraction and healing with a photocrosslinkable chitosan hydrogel. Wound Repair Regen 2001; 9: 513–521
  • Johansson F, Hjertberg E, Eirefelt S, Tronde A, Bengtsson UH. Mechanism for absorption enhancement of inhaled insulin by sodium taurocholate. Eur J Pharm Sci 2002; 17: 63–71
  • Jonker C, Hamman JH, Kotzé AF. Intestinal paracellular permeation enhancement with quaternised chitosan: In situ and in vitro evaluation. Int J Pharm 2002; 238: 205–213
  • Kasaai MR, Charlet G, Arul J. Master curve concentration dependence of semi-dilute solution viscosity of chitosan homologues: The Martin equation. Food Res Int 2000; 33: 63–67
  • Kahn CR, Shschter Y. Insulin, oral hypoglycaemic agents, and the pharmacology of the endocrine pancreas. The pharmacological basis of therapeutics, A Gilman, T Rall, A Nies, P Taylor. Pergamon Press, New York 1990; 1463–1495
  • Kotzé AF, Lueßen HL, De Leeuw BJ, De Boer AG, Verhoef JC, Junginger HE. N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: In vitro evaluation in intestinal epithelial cells (Caco-2). Pharm Res 1997; 14: 1197–1202
  • Kotze AF, Thaou M, Verhoef JC, Junginger HE. Chitosan and N-trimethyl chitosan chloride as absorption enhancer for nasal and rectal delivery of insulin. Proc Int Symp Control Rel Bioact Mater 1998; 25: 479
  • Kotzé AF, Lueßen HL, De Boer AG, Verhoef JC, Junginger HE. Chitosan for enhanced intestinal permeability: Prospects for derivatives soluble in neutral and basic environments. Eur J Pharm Sci 1999; 7: 145–151
  • Liversidge GG, Nishihata T, Engle KK, Higuchi T. Effect of suppository shape on the systemic availability of rectally administered insulin and sodium salicylate. Int J Pharm 1986; 30: 247–250
  • Mackay M, Phillips J, Hastewell J. Peptide drug delivery: Colonic and rectal absorption. Adv Drug Deliv Rev 1997; 28: 253–273
  • Matsubara K, Abe K, Irie T, Uekama K. Improvement of nasal bioavailability of luteinizing hormone-releasing hormone agonist, buserelin, by cyclodextrin derivatives in rats. J Pharm Sci 1995; 84: 1295–1300
  • Morimoto K, Takeeda T, Nakamoto Y, Morisaka K. Effective vaginal absorption of insulin in diabetic rats and rabbits using polyacrylic acid aqueous gel bases. Int J Pharm 1982; 12: 107–111
  • Morishita M, Kajita M, Suzuki A, Takayama K, Chiba Y, Tokiwa S, Nagai T. The dose-related hypoglycemic effects of insulin emulsions incorporating highly purifie d EPA and DHA. Int J Pharm 2000; 201: 175–185
  • Muranishi S, Yamamoto A, Okada H. Rectal and vaginal absorption of peptides and proteins. Biological barriers to protein delivery, K Audus, T Raub. Plenium Press, New York and London 1993; 199–227
  • Nishihata T, Rytting JH. Absorption-promoting adjuvants: Enhancing action on rectal absorption. Adv Drug Deliv Rev 1997; 28: 205–228
  • Rao SB, Sharma CP. Use of chitosan as a biomaterial: Studies on its safety and hemostatic potential. J Biomed Mater Res 1997; 34: 21–28
  • Richardson JL, Illum L. The vaginal route of peptide and protein drug delivery. Adv Drug Deliv Rev 1992; 8: 341–366
  • Richardson JL, Illum L, Thomas NW. Vaginal absorption of insulin in the rat: Effect of penetration enhancers on insulin uptake and mucosal histology. Pharm Res 1992a; 9: 878–883
  • Richardson JL, Farraj NF, Illum L. Enhanced vaginal absorption of insulin in sheep using lysophosphatidylcholine and a bioadhesive microsphere delivery system. Int J Pharm 1992b; 88: 319–325
  • Schipper NGM, Olsson S, Hoogstraate JA, De Boer AG, Varum KM, Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs 2. Mechanism of absorption enhancement. Pharm Res 1997; 14: 923–929
  • Senel S, Hincal AA. Drug permeation enhancement via buccal route: Possibilities and limitations. J Control Rel 2001; 72: 133–144
  • Senel S, Kremer MJ, Wertz PW, Hill JR, Kas S, Hincal AA, Squier CA. Chitosan for intraoral peptide delivery. Chitosan in pharmacy and chemistry, RAA Muzzarelli, C Muzzarelli. Atec, Italy 2002; 77–84
  • Siddiqui O, Chien YW. Nonparenteral administration of peptide and protein drugs. Crit Rev Ther Drug Carrier Syst 1987; 3: 195–208
  • Takayama K, Hirata M, Machida Y, Masada T, Sanan T, Nagai T. Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablets consisting of chitosan hyaluronate. Chem Pharm Bull 1990; 38: 1993–1997
  • Tozaki H, Komoike J, Tada C, Maruyama T, Terabe A, Suzuki T, Yamamato A, Muranishi S. Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from rat colon. J Pharm Sci 1997; 86: 1016–1021
  • Touitou E, Donbrow M, Azaz E. New hydrophilic vehicle enabling rectal and vaginal absorption of insulin, heparin, phenol red and gentamicin. J. Pharm. Pharmacol 1978; 30: 662–663
  • Van Der Lubben IM, Verhoef JC, Borchard G, Junginger HE. Chitosan and its derivatives in mucosal drug and vaccine delivery. Eur. J Pharm Sci 2001; 4: 201–207
  • Van der Merwe SM, Verhoef JC, Kotzé AF, Junginger HE. N-trimethyl chitosan chloride (TMC) as absorption enhancer in oral peptide drug delivery. Development and characterization of minitablet and granule formulations. Eur J Pharm Biopharm 2004; 57: 85–91
  • Ward PD, Tipin TK, Thakker DR. Enhancing paracellular permeability by modulating epithelial tight junctions. PSTT 2000; 3: 346–357
  • Yamamoto A, Muranishi S. Rectal drug delivery systems improvement of rectal peptide absorption by absorption enhancers, protease inhibitors and chemical modification. Adv Drug Deliv Rev 1997; 28: 275–299

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